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Mmp2 matrix metallopeptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81686, updated on 22-Sep-2022

Summary

Official Symbol
Mmp2provided by RGD
Official Full Name
matrix metallopeptidase 2provided by RGD
Primary source
RGD:621316
See related
Ensembl:ENSRNOG00000016695 AllianceGenome:RGD:621316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 651.0), Lung (RPKM 536.0) and 8 other tissues See more
Orthologs
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Genomic context

See Mmp2 in Genome Data Viewer
Location:
19p11
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (14154657..14182870, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15542771..15570589, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain, small subunit 2 Neighboring gene uncharacterized LOC120098543 Neighboring gene uncharacterized LOC120098544 Neighboring gene uncharacterized LOC120098590

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood vessel maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone trabecula formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to UV-A IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-A ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intramembranous ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in luteinization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ovarian follicle development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ovulation from ovarian follicle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in peripheral nervous system axon regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
72 kDa type IV collagenase
Names
72 kDa gelatinase
MMP-2
gelatinase A
matrix metalloproteinase-2
NP_112316.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031054.2NP_112316.2  72 kDa type IV collagenase precursor

    See identical proteins and their annotated locations for NP_112316.2

    Status: PROVISIONAL

    Source sequence(s)
    U65656
    UniProtKB/Swiss-Prot
    P33436, Q6GMM9
    Related
    ENSRNOP00000022679.7, ENSRNOT00000022679.7
    Conserved Domains (4) summary
    smart00059
    Location:342390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:468662
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118446
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    14154657..14182870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)