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Mmp2 matrix metallopeptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81686, updated on 10-Jun-2018
Official Symbol
Mmp2provided by RGD
Official Full Name
matrix metallopeptidase 2provided by RGD
Primary source
RGD:621316
See related
Ensembl:ENSRNOG00000016695
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Uterus (RPKM 651.0), Lung (RPKM 536.0) and 8 other tissues See more
Orthologs
See Mmp2 in Genome Data Viewer
Location:
19p11
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15542771..15570589, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (26629728..26658966, complement)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain, small subunit 2 Neighboring gene uncharacterized LOC108348898 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
blood vessel maturation ISO
Inferred from Sequence Orthology
more info
 
bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
bone trabecula formation ISO
Inferred from Sequence Orthology
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
heart development IDA
Inferred from Direct Assay
more info
PubMed 
intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
intramembranous ossification ISO
Inferred from Sequence Orthology
more info
 
luteinization IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
ovarian follicle development IDA
Inferred from Direct Assay
more info
PubMed 
ovulation from ovarian follicle IEP
Inferred from Expression Pattern
more info
PubMed 
parturition IEP
Inferred from Expression Pattern
more info
PubMed 
peripheral nervous system axon regeneration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
sarcomere ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
72 kDa type IV collagenase
Names
72 kDa gelatinase
MMP-2
gelatinase A
matrix metalloproteinase-2
NP_112316.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031054.2NP_112316.2  72 kDa type IV collagenase precursor

    See identical proteins and their annotated locations for NP_112316.2

    Status: PROVISIONAL

    Source sequence(s)
    U65656
    UniProtKB/Swiss-Prot
    P33436
    Related
    ENSRNOP00000022679.6, ENSRNOT00000022679.6
    Conserved Domains (5) summary
    smart00059
    Location:342390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:468662
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:118446
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:118446
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    15542771..15570589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    14077766..14105839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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