Format

Send to:

Choose Destination

MMP2 matrix metallopeptidase 2 [ Homo sapiens (human) ]

Gene ID: 4313, updated on 17-Nov-2018

Summary

Official Symbol
MMP2provided by HGNC
Official Full Name
matrix metallopeptidase 2provided by HGNC
Primary source
HGNC:HGNC:7166
See related
Ensembl:ENSG00000087245 MIM:120360; Vega:OTTHUMG00000133202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II
Summary
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Broad expression in gall bladder (RPKM 482.6), urinary bladder (RPKM 341.0) and 15 other tissues See more
Orthologs

Genomic context

See MMP2 in Genome Data Viewer
Location:
16q12.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (55478830..55506691)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (55513081..55540586)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs23 Neighboring gene MMP2 antisense RNA 1 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene solute carrier family 6 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 JRFL Env (gp120) upregulates MMP2 in ARPE-19 and primary human RPE cells and is dependent upon DC-SIGN PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
env Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120 PubMed
Envelope transmembrane glycoprotein gp41 env Treatment of human glial and neuronal cells with an HIV-1 gp41 peptide (amino acids 583-599) markedly increases the activity of matrix metalloproteinase 2 (MMP-2) PubMed
Nef nef Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells PubMed
Tat tat HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity PubMed
tat HIV-1 Tat and methamphetamine enhance the release of MMP-1, MMP-2, and uPA from human brain cells PubMed
tat HIV-1 Tat and bFGF synergize to upregulate MMP-2 (type-IV collagenase) secretion and activation in endothelial cells and also synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice as a result of enhanced MMP-2 expression PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen catabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
PubMed 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
72 kDa type IV collagenase
Names
collagenase type IV-A
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metalloproteinase-2
matrix metalloproteinase-II
neutrophil gelatinase
NP_001121363.1
NP_001289437.1
NP_001289438.1
NP_001289439.1
NP_004521.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008989.1 RefSeqGene

    Range
    5001..32523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127891.2NP_001121363.1  72 kDa type IV collagenase isoform 2

    See identical proteins and their annotated locations for NP_001121363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC007336, AK310314, BQ004983, BX357054
    Consensus CDS
    CCDS45487.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000394237.2, OTTHUMP00000254842, ENST00000437642.6, OTTHUMT00000433261
    Conserved Domains (5) summary
    smart00059
    Location:292340
    FN2; Fibronectin type 2 domain
    cd00094
    Location:416610
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:68396
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:68396
    Peptidase_M10; Matrixin
    pfam01471
    Location:2047
    PG_binding_1; Putative peptidoglycan binding domain
  2. NM_001302508.1NP_001289437.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AC007336, AK301536, BQ004983, BX357054, DA579926
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  3. NM_001302509.1NP_001289438.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AK301536, BQ004983, BX357054
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000444143.1, OTTHUMP00000254841, ENST00000543485.5, OTTHUMT00000433260
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  4. NM_001302510.1NP_001289439.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AK301536, AU133104, BQ004983, BX357054
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000461421.1, OTTHUMP00000258222, ENST00000570308.5, OTTHUMT00000440029
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  5. NM_004530.5NP_004521.1  72 kDa type IV collagenase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_004521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007336, AK312711, BP341649, BQ004983, BX357054, DA739456
    Consensus CDS
    CCDS10752.1
    UniProtKB/Swiss-Prot
    P08253
    UniProtKB/TrEMBL
    A0A024R6R4
    Related
    ENSP00000219070.4, OTTHUMP00000164261, ENST00000219070.8, OTTHUMT00000256913
    Conserved Domains (4) summary
    smart00059
    Location:342390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:466660
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118446
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    55478830..55506691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center