U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mmp2 matrix metallopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 17390, updated on 17-Jan-2023

Summary

Official Symbol
Mmp2provided by MGI
Official Full Name
matrix metallopeptidase 2provided by MGI
Primary source
MGI:MGI:97009
See related
Ensembl:ENSMUSG00000031740 AllianceGenome:MGI:97009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GelA; Clg4a; MMP-2
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]
Expression
Broad expression in mammary gland adult (RPKM 186.0), subcutaneous fat pad adult (RPKM 130.0) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mmp2 in Genome Data Viewer
Location:
8 C5; 8 44.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93553920..93580049)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (92827290..92853421)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Iroquois homeobox 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 16 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain, small subunit 2 Neighboring gene predicted gene 2947

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood vessel maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within bone trabecula formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within collagen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intramembranous ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in peripheral nervous system axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tissue remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
72 kDa type IV collagenase
Names
72 kDa gelatinase
72kD gelatinase
72kD type IV collagenase
72kDa gelatinase
72kDa type IV collagenase
gelatinase A
matrix metalloproteinase 2
NP_032636.1
XP_006530814.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008610.3NP_032636.1  72 kDa type IV collagenase preproprotein

    See identical proteins and their annotated locations for NP_032636.1

    Status: REVIEWED

    Source sequence(s)
    AC121604, BC070430, W53462
    Consensus CDS
    CCDS22523.1
    UniProtKB/Swiss-Prot
    P33434
    UniProtKB/TrEMBL
    A0A6P7R893, Q3UG07
    Related
    ENSMUSP00000034187.8, ENSMUST00000034187.9
    Conserved Domains (4) summary
    smart00059
    Location:342390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:468662
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118446
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93553920..93580049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530751.4XP_006530814.1  72 kDa type IV collagenase isoform X1

    Conserved Domains (5) summary
    smart00059
    Location:384432
    FN2; Fibronectin type 2 domain
    smart00235
    Location:408489
    ZnMc; Zinc-dependent metalloprotease
    cd00094
    Location:510704
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118219
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain