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TMEM163 transmembrane protein 163 [ Homo sapiens (human) ]

Gene ID: 81615, updated on 17-Jun-2024

Summary

Official Symbol
TMEM163provided by HGNC
Official Full Name
transmembrane protein 163provided by HGNC
Primary source
HGNC:HGNC:25380
See related
Ensembl:ENSG00000152128 MIM:618978; AllianceGenome:HGNC:25380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC29; SV31; HLD25; SLC30A11
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in zinc ion import into synaptic vesicle. Predicted to be located in early endosome membrane. Predicted to be active in intracellular vesicle and plasma membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 2.2), brain (RPKM 1.9) and 15 other tissues See more
Orthologs
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Genomic context

See TMEM163 in Genome Data Viewer
Location:
2q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134455759..134719000, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (134895326..135159268, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135213330..135476570, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135002234-135002734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135002735-135003235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16551 Neighboring gene RNA, 5S ribosomal pseudogene 104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16561 Neighboring gene epididymal protein 3C, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:135129934-135130438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16562 Neighboring gene Sharpr-MPRA regulatory region 6492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135201292-135201792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135217811-135218312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135218313-135218812 Neighboring gene Sharpr-MPRA regulatory region 15464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135240067-135240597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135240598-135241127 Neighboring gene uncharacterized LOC124906076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135293574-135294074 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:135318760-135318939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16563 Neighboring gene MPRA-validated peak3868 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11977 Neighboring gene uncharacterized LOC105373629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11978 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:135478596-135479795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16565 Neighboring gene chromosome 18 open reading frame 32 pseudogene Neighboring gene VDAC2 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Leukodystrophy, hypomyelinating, 25
MedGen: C5830275 OMIM: 620243 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 163 (TMEM163) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30176, DKFZp566N034, DKFZp666J217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion import into synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030923.5NP_112185.1  transmembrane protein 163

    See identical proteins and their annotated locations for NP_112185.1

    Status: VALIDATED

    Source sequence(s)
    AI307369, AW131848, BC026170, BM998960, CD705559
    Consensus CDS
    CCDS2172.1
    UniProtKB/Swiss-Prot
    Q53QM3, Q53SV7, Q69YH3, Q8TC26, Q9UFG3
    Related
    ENSP00000281924.6, ENST00000281924.6
    Conserved Domains (1) summary
    cl30791
    Location:79276
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    134455759..134719000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    134895326..135159268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)