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TMEM163 transmembrane protein 163 [ Homo sapiens (human) ]

Gene ID: 81615, updated on 22-Sep-2022


Official Symbol
TMEM163provided by HGNC
Official Full Name
transmembrane protein 163provided by HGNC
Primary source
See related
Ensembl:ENSG00000152128 MIM:618978; AllianceGenome:HGNC:25380
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC29; SV31
Predicted to enable zinc ion binding activity. Predicted to be involved in zinc ion import into synaptic vesicle. Predicted to be located in early endosome membrane. Predicted to be active in intracellular vesicle and plasma membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Broad expression in lung (RPKM 2.2), brain (RPKM 1.9) and 15 other tissues See more
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Genomic context

See TMEM163 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134455759..134719000, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (134895326..135159268, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135213330..135476570, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Neighboring gene epididymal protein 3C, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6492 Neighboring gene Sharpr-MPRA regulatory region 15464 Neighboring gene uncharacterized LOC124906076 Neighboring gene uncharacterized LOC105373629 Neighboring gene chromosome 18 open reading frame 32 pseudogene Neighboring gene VDAC2 pseudogene 4

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 163 (TMEM163) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ30176, DKFZp566N034, DKFZp666J217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
Process Evidence Code Pubs
involved_in zinc ion import into synaptic vesicle IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030923.5NP_112185.1  transmembrane protein 163

    See identical proteins and their annotated locations for NP_112185.1

    Status: VALIDATED

    Source sequence(s)
    AI307369, AW131848, BC026170, BM998960, CD705559
    Consensus CDS
    Q8TC26, Q9UFG3
    ENSP00000281924.6, ENST00000281924.6
    Conserved Domains (1) summary
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    134455759..134719000 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060926.1 Alternate T2T-CHM13v2.0

    134895326..135159268 complement
    GenBank, FASTA, Sequence Viewer (Graphics)