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TMEM163 transmembrane protein 163 [ Homo sapiens (human) ]

Gene ID: 81615, updated on 17-Jun-2019

Summary

Official Symbol
TMEM163provided by HGNC
Official Full Name
transmembrane protein 163provided by HGNC
Primary source
HGNC:HGNC:25380
See related
Ensembl:ENSG00000152128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC29; SV31
Expression
Broad expression in lung (RPKM 2.2), brain (RPKM 1.9) and 15 other tissues See more
Orthologs

Genomic context

See TMEM163 in Genome Data Viewer
Location:
2q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (134455759..134720934, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135213330..135478219, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Neighboring gene RNA, 5S ribosomal pseudogene 104 Neighboring gene epididymal protein 3C, pseudogene Neighboring gene uncharacterized LOC105373629 Neighboring gene chromosome 18 open reading frame 32 pseudogene Neighboring gene voltage dependent anion channel 2 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
NHGRI GWA Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 163 (TMEM163) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ30176, DKFZp566N034, DKFZp666J217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
zinc ion import into synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030923.5NP_112185.1  transmembrane protein 163

    See identical proteins and their annotated locations for NP_112185.1

    Status: VALIDATED

    Source sequence(s)
    AI307369, AW131848, BC026170, BM998960, CD705559
    Consensus CDS
    CCDS2172.1
    UniProtKB/Swiss-Prot
    Q8TC26
    Related
    ENSP00000281924.6, ENST00000281924.6
    Conserved Domains (1) summary
    cl25570
    Location:79276
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    134455759..134720934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511950.2XP_011510252.1  transmembrane protein 163 isoform X2

    See identical proteins and their annotated locations for XP_011510252.1

    Conserved Domains (1) summary
    COG0053
    Location:11165
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
  2. XM_017005061.1XP_016860550.1  transmembrane protein 163 isoform X2

    Conserved Domains (1) summary
    COG0053
    Location:11165
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
  3. XM_017005060.2XP_016860549.1  transmembrane protein 163 isoform X1

  4. XM_017005062.1XP_016860551.1  transmembrane protein 163 isoform X3

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