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Tmem163 transmembrane protein 163 [ Mus musculus (house mouse) ]

Gene ID: 72160, updated on 11-Jun-2024

Summary

Official Symbol
Tmem163provided by MGI
Official Full Name
transmembrane protein 163provided by MGI
Primary source
MGI:MGI:1919410
See related
Ensembl:ENSMUSG00000026347 AllianceGenome:MGI:1919410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SV31; A-cre; Act-Cre; actin-cre; cre<actin>; 2610024A01Rik; Tg(ACTB-cre)2Mrt
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in zinc ion import into synaptic vesicle. Located in intracellular vesicle. Is integral component of synaptic vesicle membrane. Is active in plasma membrane. Is expressed in cerebral cortex; cortical layer V; cortical subplate; heart; and limb. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 15.9), lung adult (RPKM 9.4) and 9 other tissues See more
Orthologs
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Genomic context

See Tmem163 in Genome Data Viewer
Location:
1 E3; 1 55.77 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127418079..127605758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127490342..127678021, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mannoside acetylglucosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_02135 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129321878-129322179 Neighboring gene predicted gene, 51746 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129355594-129355895 Neighboring gene predicted gene, 41947 Neighboring gene STARR-positive B cell enhancer ABC_E3299 Neighboring gene STARR-seq mESC enhancer starr_02141 Neighboring gene STARR-positive B cell enhancer ABC_E3300 Neighboring gene VISTA enhancer mm790 Neighboring gene STARR-positive B cell enhancer ABC_E9476 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129576446-129576747 Neighboring gene STARR-seq mESC enhancer starr_02145 Neighboring gene RIKEN cDNA 2900009J06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3301 Neighboring gene predicted gene, 35993 Neighboring gene amino carboxymuconate semialdehyde decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular vesicle EXP
Inferred from Experiment
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane EXP
Inferred from Experiment
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protein 163
Names
TgN(ACTB-cre)2Mrt
beta-actin-cre
synaptic vesicle membrane protein of 31 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028135.2NP_082411.1  transmembrane protein 163

    See identical proteins and their annotated locations for NP_082411.1

    Status: VALIDATED

    Source sequence(s)
    AC130527, AK042650, CA319657
    Consensus CDS
    CCDS35696.1
    UniProtKB/Swiss-Prot
    Q8C8I2, Q8C996, Q9D0E0
    Related
    ENSMUSP00000140828.2, ENSMUST00000185560.2
    Conserved Domains (1) summary
    pfam01545
    Location:100273
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    127418079..127605758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)