Tmem163 transmembrane protein 163 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem163provided by MGI
Official Full Name: transmembrane protein 163provided by MGI
Primary source: MGI:MGI:1919410
See related: Ensembl:ENSMUSG00000026347 AllianceGenome:MGI:1919410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SV31; A-cre; Act-Cre; actin-cre; cre<actin>; 2610024A01Rik; Tg(ACTB-cre)2Mrt
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in zinc ion import into synaptic vesicle. Located in intracellular vesicle. Is integral component of synaptic vesicle membrane. Is active in plasma membrane. Is expressed in cerebral cortex; cortical layer V; cortical subplate; heart; and limb. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 15.9), lung adult (RPKM 9.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 E3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (127418079..127605758, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (127490342..127678021, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules.
Title: A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules.
TMEM163 Regulates ATP-Gated P2X Receptor and Behavior.
Title: TMEM163 Regulates ATP-Gated P2X Receptor and Behavior.
Role of Tmem163 in zinc-regulated insulin storage of MIN6 cells: Functional exploration of an Indian type 2 diabetes GWAS associated gene.
Title: Role of Tmem163 in zinc-regulated insulin storage of MIN6 cells: Functional exploration of an Indian type 2 diabetes GWAS associated gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

D1Mit495 (e-PCR), detects polymorphism
- UniSTS:128863

28.MHAa65T_M13Rev.seq (e-PCR)
- UniSTS:123813

Homology

Homologs of the Tmem163 gene: The Tmem163 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 344 organisms have orthologs with human gene Tmem163
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in zinc ion import into synaptic vesicle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in intracellular vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in plasma membrane	EXP Inferred from Experiment more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 163

Names: TgN(ACTB-cre)2Mrt; beta-actin-cre; synaptic vesicle membrane protein of 31 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.