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ANP32A acidic nuclear phosphoprotein 32 family member A [ Homo sapiens (human) ]

Gene ID: 8125, updated on 12-Mar-2019

Summary

Official Symbol
ANP32Aprovided by HGNC
Official Full Name
acidic nuclear phosphoprotein 32 family member Aprovided by HGNC
Primary source
HGNC:HGNC:13233
See related
Ensembl:ENSG00000140350 MIM:600832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
Expression
Ubiquitous expression in lymph node (RPKM 45.8), bone marrow (RPKM 40.5) and 25 other tissues See more
Orthologs

Genomic context

See ANP32A in Genome Data Viewer
Location:
15q23
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (68778535..68820922, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69070874..69113261, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene coronin 2B Neighboring gene heart enhancer 11 Neighboring gene cysteinyl-tRNA synthetase pseudogene 1 Neighboring gene ANP32A intronic transcript 1 Neighboring gene microRNA 4312 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene sperm equatorial segment protein 1 Neighboring gene NADPH oxidase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev The interaction of Rev with ANP32A is decreased by the presence of RRE PubMed
rev HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HuR (ELAVL1) binds and stabilizes mRNA, organism-specific biosystem (from REACTOME)
    HuR (ELAVL1) binds and stabilizes mRNA, organism-specific biosystemHuR (ELAVL1) is a ubiquitous protein that binds AU-rich elements in mRNAs and acts to stabilize the mRNAs. HuR activity is controlled by phosphorylation, with PKC alpha and PCK delta enhancing the ab...
  • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
    Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119787, MGC150373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member A
Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
acidic nuclear phosphoprotein pp32
cerebellar leucine rich acidic nuclear protein
epididymis secretory sperm binding protein
hepatopoietin Cn
inhibitor-1 of protein phosphatase-2A
leucine-rich acidic nuclear protein
mapmodulin
potent heat-stable protein phosphatase 2A inhibitor I1PP2A
putative HLA-DR-associated protein I
putative human HLA class II associated protein I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006305.4NP_006296.1  acidic leucine-rich nuclear phosphoprotein 32 family member A

    See identical proteins and their annotated locations for NP_006296.1

    Status: VALIDATED

    Source sequence(s)
    BC007200, BC064969, DA825897
    Consensus CDS
    CCDS45292.1
    UniProtKB/Swiss-Prot
    P39687
    Related
    ENSP00000417864.2, ENST00000465139.6
    Conserved Domains (2) summary
    sd00033
    Location:90114
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:71146
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    68778535..68820922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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