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Anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A [ Mus musculus (house mouse) ]

Gene ID: 11737, updated on 8-Jan-2023

Summary

Official Symbol
Anp32aprovided by MGI
Official Full Name
acidic (leucine-rich) nuclear phosphoprotein 32 family, member Aprovided by MGI
Primary source
MGI:MGI:108447
See related
Ensembl:ENSMUSG00000032249 AllianceGenome:MGI:108447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LANP; pp32; Anp32; PHAP1; I1PP2A
Summary
Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Located in nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 178.7), CNS E14 (RPKM 62.2) and 15 other tissues See more
Orthologs
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Genomic context

See Anp32a in Genome Data Viewer
Location:
9 B; 9 33.68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62248625..62286086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62341343..62378804)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sperm equatorial segment protein 1 Neighboring gene mitochondrial ribosomal protein S16 pseudogene Neighboring gene predicted gene, 20346 Neighboring gene predicted gene, 40522 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member A
Names
acidic nuclear phosphoprotein 32
acidic nuclear phosphoprotein pp32
leucine-rich acidic nuclear protein
potent heat-stable protein phosphatase 2A inhibitor I1PP2A
vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411151.1NP_001398080.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813
  2. NM_001411152.1NP_001398081.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813
    UniProtKB/TrEMBL
    A0A6P5QAW7, D3Z7M9
  3. NM_009672.4NP_033802.2  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1

    See identical proteins and their annotated locations for NP_033802.2

    Status: VALIDATED

    Source sequence(s)
    AC113291, AC121813
    Consensus CDS
    CCDS40663.1
    UniProtKB/Swiss-Prot
    O35381, P97437
    UniProtKB/TrEMBL
    A0A6P5QAN7, A0A8C6G8H0
    Related
    ENSMUSP00000082652.7, ENSMUST00000085519.13
    Conserved Domains (3) summary
    sd00035
    Location:90113
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:71146
    LRR_9; Leucine-rich repeat
    NF033189
    Location:9128
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62248625..62286086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510779.5XP_006510842.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1

    UniProtKB/TrEMBL
    D3Z7M9
    Related
    ENSMUSP00000122165.2, ENSMUST00000135395.8
    Conserved Domains (2) summary
    sd00035
    Location:7699
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:57132
    LRR_9; Leucine-rich repeat
  2. XM_006510778.4XP_006510841.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2

    Conserved Domains (2) summary
    sd00035
    Location:93116
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:74149
    LRR_9; Leucine-rich repeat