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SETD7 SET domain containing 7, histone lysine methyltransferase [ Homo sapiens (human) ]

Gene ID: 80854, updated on 6-Jan-2019

Summary

Official Symbol
SETD7provided by HGNC
Official Full Name
SET domain containing 7, histone lysine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:30412
See related
Ensembl:ENSG00000145391 MIM:606594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT7; SET7; SET9; SET7/9
Expression
Ubiquitous expression in fat (RPKM 22.9), prostate (RPKM 16.7) and 24 other tissues See more
Orthologs

Genomic context

See SETD7 in Genome Data Viewer
Location:
4q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (139495934..139556769, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140427192..140477577, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene glucose-fructose oxidoreductase domain containing 2 pseudogene Neighboring gene uncharacterized LOC107984036 Neighboring gene RAB33B, member RAS oncogene family Neighboring gene ferritin heavy chain 1 pseudogene 24 Neighboring gene uncharacterized LOC105377451 Neighboring gene uncharacterized LOC105377622

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is monomethylated at lysine 71 by SETD7 (KMT7) in HEK293T and Jurkat A2 cell lines PubMed
tat HIV-1 Tat is methylated at residue lysine 51 in its RNA-binding domain by SET7/9-KMT7 PubMed
tat SET7/9-KMT7 binds directly to HIV-1 Tat and enhances recruitment of the Tat/P-TEFb complex to HIV-1 TAR RNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Histone Modifications, organism-specific biosystem (from WikiPathways)
    Histone Modifications, organism-specific biosystemHistones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the en...
  • Lysine degradation, organism-specific biosystem (from KEGG)
    Lysine degradation, organism-specific biosystem
    Lysine degradation
  • Lysine degradation, conserved biosystem (from KEGG)
    Lysine degradation, conserved biosystem
    Lysine degradation
  • PKMTs methylate histone lysines, organism-specific biosystem (from REACTOME)
    PKMTs methylate histone lysines, organism-specific biosystemLysine methyltransferases (KMTs) and arginine methyltransferases (RMTs) have a common mechanism of catalysis. Both families transfer a methyl group from a common donor, S-adenosyl-L-methionine (SAM),...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21193, KIAA1717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
histone-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
heterochromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
histone lysine methylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine dimethylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine monomethylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of histone H3-K9 methylation IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase SETD7
Names
H3-K4-HMTase SETD7
SET domain containing 7, lysine methyltransferase
SET domain containing lysine methyltransferase 7
SET domain-containing protein 7
histone H3-K4 methyltransferase SETD7
histone H3-lysine 4-specific methyltransferase
lysine N-methyltransferase 7
NP_001293128.1
NP_001293129.1
NP_085151.1
XP_016864150.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306199.1NP_001293128.1  histone-lysine N-methyltransferase SETD7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon that results in a different 3' UTR and a novel 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AB051504, AC114743, AI985614, AK310856, BC110904
    Consensus CDS
    CCDS77961.1
    UniProtKB/Swiss-Prot
    Q8WTS6
    UniProtKB/TrEMBL
    D6RJA0
    Related
    ENSP00000427300.1, ENST00000506866.6
    Conserved Domains (1) summary
    smart00317
    Location:226303
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  2. NM_001306200.1NP_001293129.1  histone-lysine N-methyltransferase SETD7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, lacks exons in the 3' coding region, and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC110904
    Consensus CDS
    CCDS82956.1
    UniProtKB/TrEMBL
    B5MCZ8
    Related
    ENSP00000385913.3, ENST00000404104.7
    Conserved Domains (1) summary
    COG2849
    Location:37123
    YwqK; Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]
  3. NM_030648.3NP_085151.1  histone-lysine N-methyltransferase SETD7 isoform 1

    See identical proteins and their annotated locations for NP_085151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB051504, AC114743, AK024846, BC040990, BC110904, BM922680
    Consensus CDS
    CCDS3748.1
    UniProtKB/Swiss-Prot
    Q8WTS6
    Related
    ENSP00000274031.3, ENST00000274031.7
    Conserved Domains (2) summary
    smart00317
    Location:226342
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2849
    Location:37134
    YwqK; Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]

RNA

  1. NR_131339.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, lacks alternate exons, and has a 3' end that extends into an intron compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC066361, BC110904

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    139495934..139556769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008661.1XP_016864150.1  histone-lysine N-methyltransferase SETD7 isoform X1

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