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KDM7A lysine demethylase 7A [ Homo sapiens (human) ]

Gene ID: 80853, updated on 22-Sep-2022

Summary

Official Symbol
KDM7Aprovided by HGNC
Official Full Name
lysine demethylase 7Aprovided by HGNC
Primary source
HGNC:HGNC:22224
See related
Ensembl:ENSG00000006459 MIM:619640; AllianceGenome:HGNC:22224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JHDM1D
Summary
Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 9.6), colon (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See KDM7A in Genome Data Viewer
Location:
7q34
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140084746..140176983, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141398329..141490536, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139784546..139876783, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 12 Neighboring gene uncharacterized LOC124901757 Neighboring gene Sharpr-MPRA regulatory region 991 Neighboring gene KDM7A divergent transcript Neighboring gene RNA, U6 small nuclear 797, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of jumonji C domain containing histone demethylase 1 homolog D (JHDM1D) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1718

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone modification IEA
Inferred from Electronic Annotation
more info
 
involved_in midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
lysine-specific demethylase 7A
Names
[histone H3]-dimethyl-L-lysine9 demethylase 7A
histone lysine demethylase JHDM1D
jmjC domain-containing histone demethylation protein 1D
jumonji C domain containing histone demethylase 1 homolog D
lysine (K)-specific demethylase 7A
lysine-specific demethylase 7
NP_085150.1
XP_011514889.1
XP_047276835.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030647.2NP_085150.1  lysine-specific demethylase 7A

    See identical proteins and their annotated locations for NP_085150.1

    Status: VALIDATED

    Source sequence(s)
    AB051505, AC004849, AK131497
    Consensus CDS
    CCDS43658.1
    UniProtKB/Swiss-Prot
    Q6ZMT4, Q9C0E5
    Related
    ENSP00000380692.2, ENST00000397560.7
    Conserved Domains (3) summary
    smart00558
    Location:234297
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    cd15640
    Location:3988
    PHD_KDM7; PHD finger found in lysine-specific demethylase 7 (KDM7)
    cl21464
    Location:269369
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    140084746..140176983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516587.3XP_011514889.1  lysine-specific demethylase 7A isoform X2

    See identical proteins and their annotated locations for XP_011514889.1

  2. XM_047420879.1XP_047276835.1  lysine-specific demethylase 7A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    141398329..141490536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)