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KDM7A lysine demethylase 7A [ Homo sapiens (human) ]

Gene ID: 80853, updated on 1-Jun-2020

Summary

Official Symbol
KDM7Aprovided by HGNC
Official Full Name
lysine demethylase 7Aprovided by HGNC
Primary source
HGNC:HGNC:22224
See related
Ensembl:ENSG00000006459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JHDM1D
Expression
Ubiquitous expression in bone marrow (RPKM 9.6), colon (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See KDM7A in Genome Data Viewer
Location:
7q34
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (140084746..140176983, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139784546..139876741, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC105375532 Neighboring gene poly(ADP-ribose) polymerase family member 12 Neighboring gene KDM7A divergent transcript Neighboring gene RNA, U6 small nuclear 797, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of jumonji C domain containing histone demethylase 1 homolog D (JHDM1D) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1718

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone H3-K27 demethylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K36 demethylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K9 demethylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K20 demethylation IDA
Inferred from Direct Assay
more info
PubMed 
midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
lysine-specific demethylase 7A
Names
histone lysine demethylase JHDM1D
jmjC domain-containing histone demethylation protein 1D
jumonji C domain containing histone demethylase 1 homolog D
lysine (K)-specific demethylase 7A
lysine-specific demethylase 7
NP_085150.1
XP_011514889.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030647.2NP_085150.1  lysine-specific demethylase 7A

    See identical proteins and their annotated locations for NP_085150.1

    Status: VALIDATED

    Source sequence(s)
    AB051505, AC004849, AK131497
    Consensus CDS
    CCDS43658.1
    UniProtKB/Swiss-Prot
    Q6ZMT4
    Related
    ENSP00000380692.2, ENST00000397560.7
    Conserved Domains (3) summary
    smart00558
    Location:234297
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    cd15640
    Location:3988
    PHD_KDM7; PHD finger found in lysine-specific demethylase 7 (KDM7)
    cl21464
    Location:269369
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    140084746..140176983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516587.2XP_011514889.1  lysine-specific demethylase 7A isoform X1

    See identical proteins and their annotated locations for XP_011514889.1

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