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Kdm7a lysine (K)-specific demethylase 7A [ Mus musculus (house mouse) ]

Gene ID: 338523, updated on 24-Oct-2020

Summary

Official Symbol
Kdm7aprovided by MGI
Official Full Name
lysine (K)-specific demethylase 7Aprovided by MGI
Primary source
MGI:MGI:2443388
See related
Ensembl:ENSMUSG00000042599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kdm7; Jhdm1d; BB041802; mKIAA1718; A630082K20Rik
Expression
Ubiquitous expression in liver E14 (RPKM 5.3), liver E14.5 (RPKM 4.4) and 28 other tissues See more
Orthologs

Genomic context

See Kdm7a in Genome Data Viewer
Location:
6; 6 B1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39113554..39183707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39136620..39206773, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (39086619..39156772, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene predicted gene, 38794 Neighboring gene predicted gene, 34147

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
histone demethylase activity (H3-K27 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone demethylase activity (H3-K27 specific) ISO
Inferred from Sequence Orthology
more info
 
histone demethylase activity (H3-K36 specific) ISO
Inferred from Sequence Orthology
more info
 
histone demethylase activity (H3-K9 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone demethylase activity (H3-K9 specific) ISO
Inferred from Sequence Orthology
more info
 
histone demethylase activity (H4-K20 specific) ISO
Inferred from Sequence Orthology
more info
 
iron ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
histone H3-K27 demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K27 demethylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K36 demethylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K9 demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K9 demethylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K20 demethylation ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysine-specific demethylase 7A
Names
jmjC domain-containing histone demethylation protein 1D
jumonji C domain-containing histone demethylase 1 homolog D
lysine-specific demethylase 7
NP_001028602.2
XP_036022151.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033430.4NP_001028602.2  lysine-specific demethylase 7A

    See identical proteins and their annotated locations for NP_001028602.2

    Status: VALIDATED

    Source sequence(s)
    AC153818, AK042834, AK129429, AW549902, BC145848
    Consensus CDS
    CCDS51753.1
    UniProtKB/Swiss-Prot
    Q3UWM4
    Related
    ENSMUSP00000002305.8, ENSMUST00000002305.8
    Conserved Domains (3) summary
    smart00558
    Location:234297
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    cd15640
    Location:3988
    PHD_KDM7; PHD finger found in lysine-specific demethylase 7 (KDM7)
    cl21464
    Location:269369
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39113554..39183707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166258.1XP_036022151.1  lysine-specific demethylase 7A isoform X1

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