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RIN3 Ras and Rab interactor 3 [ Homo sapiens (human) ]

Gene ID: 79890, updated on 7-Aug-2022

Summary

Official Symbol
RIN3provided by HGNC
Official Full Name
Ras and Rab interactor 3provided by HGNC
Primary source
HGNC:HGNC:18751
See related
Ensembl:ENSG00000100599 MIM:610223; AllianceGenome:HGNC:18751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Broad expression in bone marrow (RPKM 13.0), spleen (RPKM 13.0) and 24 other tissues See more
Orthologs
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Genomic context

See RIN3 in Genome Data Viewer
Location:
14q32.12
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92513781..92688994)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (86743365..86920782)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92980125..93155339)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370627 Neighboring gene solute carrier family 24 member 4 Neighboring gene uncharacterized LOC124903365 Neighboring gene uncharacterized LOC124903364 Neighboring gene legumain Neighboring gene golgin A5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns.
EBI GWAS Catalog
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
EBI GWAS Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog
IREB2 and GALC are Associated with Pulmonary Artery Enlargement in Chronic Obstructive Pulmonary Disease.
EBI GWAS Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
EBI GWAS Catalog
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
EBI GWAS Catalog
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11700, FLJ22439, DKFZp762H1613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras and Rab interactor 3
Names
RAB5 interacting protein 3
ras interaction/interference protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319987.2NP_001306916.1  ras and Rab interactor 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB081753, AK026092, AK128338, BC032614
    UniProtKB/Swiss-Prot
    Q8TB24
    UniProtKB/TrEMBL
    Q6ZRC2
    Related
    ENST00000418924.6
    Conserved Domains (4) summary
    TIGR03483
    Location:240339
    FtsZ_alphas_C; cell division protein FtsZ, alphaProteobacterial C-terminal extension
    pfam02204
    Location:665767
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl00155
    Location:807886
    UBQ; Ubiquitin-like proteins
    cl15255
    Location:978
    SH2; Src homology 2 (SH2) domain
  2. NM_024832.5NP_079108.3  ras and Rab interactor 3 isoform 1

    See identical proteins and their annotated locations for NP_079108.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB081753, AK026092, BC025248, BC070062, BX248258, DR003779
    Consensus CDS
    CCDS32144.1
    UniProtKB/Swiss-Prot
    Q8TB24, Q9HAG1
    UniProtKB/TrEMBL
    Q6NSK7, Q86U22
    Related
    ENSP00000216487.7, ENST00000216487.12
    Conserved Domains (4) summary
    cd10395
    Location:52153
    SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
    TIGR03483
    Location:315414
    FtsZ_alphas_C; cell division protein FtsZ, alphaProteobacterial C-terminal extension
    pfam02204
    Location:740842
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl00155
    Location:882961
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    92513781..92688994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021653.2XP_016877142.1  ras and Rab interactor 3 isoform X3

  2. XM_017021654.2XP_016877143.1  ras and Rab interactor 3 isoform X4

    Conserved Domains (3) summary
    cd10395
    Location:52153
    SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins
    TIGR03483
    Location:315414
    FtsZ_alphas_C; cell division protein FtsZ, alphaProteobacterial C-terminal extension
    pfam02204
    Location:740842
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  3. XM_017021652.2XP_016877141.1  ras and Rab interactor 3 isoform X1

  4. XM_011537164.4XP_011535466.1  ras and Rab interactor 3 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:164449
    PHA03247; large tegument protein UL36; Provisional
    cd16130
    Location:801888
    RA_Rin3; Ras-associating (RA) domain found in Ras and Rab interactor 3 (Rin3)
    pfam02204
    Location:663766
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:877
    SH2; Src homology 2 (SH2) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    86743365..86920782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024892.1: Suppressed sequence

    Description
    NM_024892.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.