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NEK11 NIMA related kinase 11 [ Homo sapiens (human) ]

Gene ID: 79858, updated on 2-Nov-2024

Summary

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Official Symbol
NEK11provided by HGNC
Official Full Name
NIMA related kinase 11provided by HGNC
Primary source
HGNC:HGNC:18593
See related
Ensembl:ENSG00000114670 MIM:609779; AllianceGenome:HGNC:18593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Expression
Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.7) and 22 other tissues See more
Orthologs
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Genomic context

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See NEK11 in Genome Data Viewer
Location:
3q22.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (131026877..131350465)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (133770580..134094242)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130745721..131069309)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:130761319-130762129 Neighboring gene uncharacterized LOC124909434 Neighboring gene asteroid homolog 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:130796655-130797231 Neighboring gene RNA, U6 small nuclear 726, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:130935591-130936092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131050541-131051088 Neighboring gene NUDT16 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131080535-131081079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131100488-131101057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131101058-131101626 Neighboring gene nudix hydrolase 16 like 2, pseudogene Neighboring gene nudix hydrolase 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NEK11 as a candidate high-penetrance melanoma susceptibility gene. Christodoulou E, et al. J Med Genet, 2020 Mar. PMID 31704778
  2. Never say never. The NIMA-related protein kinases in mitotic control. O'Connell MJ, et al. Trends Cell Biol, 2003 May. PMID 12742165
  3. Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents. Sabir SR, et al. PLoS One, 2015. PMID 26501353, Free PMC Article
  4. Cell cycle regulation by the NEK family of protein kinases. Fry AM, et al. J Cell Sci, 2012 Oct 1. PMID 23132929, Free PMC Article
  5. Downregulation of NEK11 is associated with drug resistance in ovarian cancer. Liu X, et al. Int J Oncol, 2014 Sep. PMID 24969318

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEK11 as a candidate high-penetrance melanoma susceptibility gene.
    Title: NEK11 as a candidate high-penetrance melanoma susceptibility gene.
  2. Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.
    Title: Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia in children.
  3. contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage
    Title: Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.
  4. Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer.
    Title: Downregulation of NEK11 is associated with drug resistance in ovarian cancer.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation.
    Title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
  7. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
  8. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
    Title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
  9. Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway
    Title: Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.
  10. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
    Title: Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek11
Names
NIMA (never in mitosis gene a)- related kinase 11
NP_001139475.1
NP_001308149.1
NP_001308150.1
NP_001308151.1
NP_001308152.1
NP_001308153.1
NP_001339951.1
NP_001339952.1
NP_001339953.1
NP_001339954.1
NP_001339955.1
NP_001339956.1
NP_001339957.1
NP_001339958.1
NP_001339959.1
NP_001339960.1
NP_001339961.1
NP_001339962.1
NP_001339963.1
NP_001339965.1
NP_001339966.1
NP_001339967.1
NP_001339968.1
NP_001339969.1
NP_001339970.1
NP_001339971.1
NP_001339972.1
NP_001339973.1
NP_001339974.1
NP_001339975.1
NP_001339977.1
NP_079076.3
NP_665917.1
XP_011511476.1
XP_011511477.1
XP_016862695.1
XP_016862696.1
XP_016862697.1
XP_016862698.1
XP_016862699.1
XP_016862709.1
XP_016862710.1
XP_016862711.1
XP_016862717.1
XP_024309524.1
XP_024309528.1
XP_047304924.1
XP_047304926.1
XP_047304927.1
XP_047304928.1
XP_047304929.1
XP_047304930.1
XP_047304932.1
XP_047304933.1
XP_047304934.1
XP_047304935.1
XP_047304936.1
XP_054203894.1
XP_054203895.1
XP_054203896.1
XP_054203897.1
XP_054203898.1
XP_054203899.1
XP_054203900.1
XP_054203901.1
XP_054203902.1
XP_054203903.1
XP_054203904.1
XP_054203905.1
XP_054203906.1
XP_054203907.1
XP_054203908.1
XP_054203909.1
XP_054203910.1
XP_054203911.1
XP_054203912.1
XP_054203913.1
XP_054203914.1
XP_054203915.1
XP_054203916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029225.1 RefSeqGene

    Range
    5028..328616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146003.2 → NP_001139475.1  serine/threonine-protein kinase Nek11 isoform 3

    See identical proteins and their annotated locations for NP_001139475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS54639.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000423458.1, ENST00000510688.5
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  2. NM_001321220.2 → NP_001308149.1  serine/threonine-protein kinase Nek11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Related
    ENSP00000421851.1, ENST00000508196.5
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  3. NM_001321221.2 → NP_001308150.1  serine/threonine-protein kinase Nek11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB071996, AC116424, AK027148, AK297300, AL833472, BI032921, BX328072
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  4. NM_001321222.2 → NP_001308151.1  serine/threonine-protein kinase Nek11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS82837.1
    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Related
    ENSP00000421549.1, ENST00000510769.5
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001321223.1 → NP_001308152.1  serine/threonine-protein kinase Nek11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC028587, DB446413
    Consensus CDS
    CCDS82836.1
    UniProtKB/Swiss-Prot
    Q8NG66
    Related
    ENSP00000426662.1, ENST00000507910.5
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  6. NM_001321224.2 → NP_001308153.1  serine/threonine-protein kinase Nek11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK293261, AK297300, AL833472
    UniProtKB/TrEMBL
    B4DDN2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001353022.2 → NP_001339951.1  serine/threonine-protein kinase Nek11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  8. NM_001353023.2 → NP_001339952.1  serine/threonine-protein kinase Nek11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  9. NM_001353024.2 → NP_001339953.1  serine/threonine-protein kinase Nek11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28 → 286
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  10. NM_001353025.2 → NP_001339954.1  serine/threonine-protein kinase Nek11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28 → 286
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  11. NM_001353026.2 → NP_001339955.1  serine/threonine-protein kinase Nek11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  12. NM_001353027.2 → NP_001339956.1  serine/threonine-protein kinase Nek11 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  13. NM_001353028.2 → NP_001339957.1  serine/threonine-protein kinase Nek11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS54639.1
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  14. NM_001353029.2 → NP_001339958.1  serine/threonine-protein kinase Nek11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS54639.1
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  15. NM_001353030.2 → NP_001339959.1  serine/threonine-protein kinase Nek11 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  16. NM_001353031.2 → NP_001339960.1  serine/threonine-protein kinase Nek11 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  17. NM_001353032.2 → NP_001339961.1  serine/threonine-protein kinase Nek11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS82837.1
    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  18. NM_001353033.2 → NP_001339962.1  serine/threonine-protein kinase Nek11 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:7 → 181
    PKc_like; Protein Kinases, catalytic domain

  19. NM_001353034.2 → NP_001339963.1  serine/threonine-protein kinase Nek11 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:7 → 181
    PKc_like; Protein Kinases, catalytic domain

  20. NM_001353036.2 → NP_001339965.1  serine/threonine-protein kinase Nek11 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563

  21. NM_001353037.2 → NP_001339966.1  serine/threonine-protein kinase Nek11 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  22. NM_001353038.2 → NP_001339967.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  23. NM_001353039.2 → NP_001339968.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  24. NM_001353040.2 → NP_001339969.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  25. NM_001353041.2 → NP_001339970.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  26. NM_001353042.2 → NP_001339971.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  27. NM_001353043.2 → NP_001339972.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  28. NM_001353044.2 → NP_001339973.1  serine/threonine-protein kinase Nek11 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  29. NM_001353045.2 → NP_001339974.1  serine/threonine-protein kinase Nek11 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  30. NM_001353046.2 → NP_001339975.1  serine/threonine-protein kinase Nek11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DDN2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  31. NM_001353048.2 → NP_001339977.1  serine/threonine-protein kinase Nek11 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  32. NM_024800.5 → NP_079076.3  serine/threonine-protein kinase Nek11 isoform 1

    See identical proteins and their annotated locations for NP_079076.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1), also known as NEK11L.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Related
    ENSP00000372857.4, ENST00000383366.9
    Conserved Domains (1) summary
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  33. NM_145910.4 → NP_665917.1  serine/threonine-protein kinase Nek11 isoform 2

    See identical proteins and their annotated locations for NP_665917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), also known as NEK11S, is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071997, AK297300, BU674219
    Consensus CDS
    CCDS46915.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000425114.1, ENST00000511262.5
    Conserved Domains (2) summary
    smart00220
    Location:29 → 287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28 → 287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    131026877..131350465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007209.2 → XP_016862698.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  2. XM_047448971.1 → XP_047304927.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

  3. XM_017007206.2 → XP_016862695.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  4. XM_047448970.1 → XP_047304926.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

  5. XM_047448972.1 → XP_047304928.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4

  6. XM_047448974.1 → XP_047304930.1  serine/threonine-protein kinase Nek11 isoform X5

  7. XM_024453756.2 → XP_024309524.1  serine/threonine-protein kinase Nek11 isoform X6

    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Conserved Domains (1) summary
    cl21453
    Location:28 → 216
    PKc_like; Protein Kinases, catalytic domain

  8. XM_047448977.1 → XP_047304933.1  serine/threonine-protein kinase Nek11 isoform X11

  9. XM_017007208.2 → XP_016862697.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  10. XM_047448968.1 → XP_047304924.1  serine/threonine-protein kinase Nek11 isoform X2

  11. XM_047448973.1 → XP_047304929.1  serine/threonine-protein kinase Nek11 isoform X4

  12. XM_047448976.1 → XP_047304932.1  serine/threonine-protein kinase Nek11 isoform X11

  13. XM_047448980.1 → XP_047304936.1  serine/threonine-protein kinase Nek11 isoform X15

  14. XM_017007221.2 → XP_016862710.1  serine/threonine-protein kinase Nek11 isoform X8

  15. XM_017007220.2 → XP_016862709.1  serine/threonine-protein kinase Nek11 isoform X7

  16. XM_047448978.1 → XP_047304934.1  serine/threonine-protein kinase Nek11 isoform X12

  17. XM_017007222.2 → XP_016862711.1  serine/threonine-protein kinase Nek11 isoform X9

  18. XM_047448979.1 → XP_047304935.1  serine/threonine-protein kinase Nek11 isoform X13

    Related
    ENSP00000349389.5, ENST00000356918.8

  19. XM_017007210.2 → XP_016862699.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  20. XM_017007207.2 → XP_016862696.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28 → 329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  21. XM_011513174.2 → XP_011511476.1  serine/threonine-protein kinase Nek11 isoform X10

    See identical proteins and their annotated locations for XP_011511476.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  22. XM_011513175.2 → XP_011511477.1  serine/threonine-protein kinase Nek11 isoform X10

    See identical proteins and their annotated locations for XP_011511477.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  23. XM_017007228.2 → XP_016862717.1  serine/threonine-protein kinase Nek11 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  24. XM_024453760.2 → XP_024309528.1  serine/threonine-protein kinase Nek11 isoform X14

    Conserved Domains (2) summary
    cl21453
    Location:1 → 105
    PKc_like; Protein Kinases, catalytic domain
    cl25539
    Location:16 → 223
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001740271.2 RNA Sequence

    Related
    ENST00000514915.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    133770580..134094242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347920.1 → XP_054203895.1  serine/threonine-protein kinase Nek11 isoform X1

  2. XM_054347925.1 → XP_054203900.1  serine/threonine-protein kinase Nek11 isoform X3

  3. XM_054347927.1 → XP_054203902.1  serine/threonine-protein kinase Nek11 isoform X3

  4. XM_054347929.1 → XP_054203904.1  serine/threonine-protein kinase Nek11 isoform X5

  5. XM_054347930.1 → XP_054203905.1  serine/threonine-protein kinase Nek11 isoform X6

  6. XM_054347937.1 → XP_054203912.1  serine/threonine-protein kinase Nek11 isoform X11

  7. XM_054347922.1 → XP_054203897.1  serine/threonine-protein kinase Nek11 isoform X1

  8. XM_054347926.1 → XP_054203901.1  serine/threonine-protein kinase Nek11 isoform X3

  9. XM_054347919.1 → XP_054203894.1  serine/threonine-protein kinase Nek11 isoform X1

  10. XM_054347924.1 → XP_054203899.1  serine/threonine-protein kinase Nek11 isoform X2

  11. XM_054347928.1 → XP_054203903.1  serine/threonine-protein kinase Nek11 isoform X4

  12. XM_054347936.1 → XP_054203911.1  serine/threonine-protein kinase Nek11 isoform X11

  13. XM_054347941.1 → XP_054203916.1  serine/threonine-protein kinase Nek11 isoform X15

  14. XM_054347932.1 → XP_054203907.1  serine/threonine-protein kinase Nek11 isoform X8

  15. XM_054347931.1 → XP_054203906.1  serine/threonine-protein kinase Nek11 isoform X7

  16. XM_054347938.1 → XP_054203913.1  serine/threonine-protein kinase Nek11 isoform X12

  17. XM_054347933.1 → XP_054203908.1  serine/threonine-protein kinase Nek11 isoform X9

  18. XM_054347939.1 → XP_054203914.1  serine/threonine-protein kinase Nek11 isoform X13

  19. XM_054347923.1 → XP_054203898.1  serine/threonine-protein kinase Nek11 isoform X1

  20. XM_054347921.1 → XP_054203896.1  serine/threonine-protein kinase Nek11 isoform X1

  21. XM_054347934.1 → XP_054203909.1  serine/threonine-protein kinase Nek11 isoform X10

  22. XM_054347935.1 → XP_054203910.1  serine/threonine-protein kinase Nek11 isoform X10

  23. XM_054347940.1 → XP_054203915.1  serine/threonine-protein kinase Nek11 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NG66.2 GenPept UniProtKB/Swiss-Prot:Q8NG66

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