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NEK11 NIMA related kinase 11 [ Homo sapiens (human) ]

Gene ID: 79858, updated on 3-Dec-2024

Summary

Official Symbol
NEK11provided by HGNC
Official Full Name
NIMA related kinase 11provided by HGNC
Primary source
HGNC:HGNC:18593
See related
Ensembl:ENSG00000114670 MIM:609779; AllianceGenome:HGNC:18593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Expression
Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.7) and 22 other tissues See more
Orthologs
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Genomic context

See NEK11 in Genome Data Viewer
Location:
3q22.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (131026877..131350465)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (133770580..134094242)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130745721..131069309)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:130761319-130762129 Neighboring gene uncharacterized LOC124909434 Neighboring gene asteroid homolog 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:130796655-130797231 Neighboring gene RNA, U6 small nuclear 726, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:130935591-130936092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131050541-131051088 Neighboring gene NUDT16 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131080535-131081079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131100488-131101057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:131101058-131101626 Neighboring gene nudix hydrolase 16 like 2, pseudogene Neighboring gene nudix hydrolase 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek11
Names
NIMA (never in mitosis gene a)- related kinase 11
NP_001139475.1
NP_001308149.1
NP_001308150.1
NP_001308151.1
NP_001308152.1
NP_001308153.1
NP_001339951.1
NP_001339952.1
NP_001339953.1
NP_001339954.1
NP_001339955.1
NP_001339956.1
NP_001339957.1
NP_001339958.1
NP_001339959.1
NP_001339960.1
NP_001339961.1
NP_001339962.1
NP_001339963.1
NP_001339965.1
NP_001339966.1
NP_001339967.1
NP_001339968.1
NP_001339969.1
NP_001339970.1
NP_001339971.1
NP_001339972.1
NP_001339973.1
NP_001339974.1
NP_001339975.1
NP_001339977.1
NP_079076.3
NP_665917.1
XP_011511476.1
XP_011511477.1
XP_016862695.1
XP_016862696.1
XP_016862697.1
XP_016862698.1
XP_016862699.1
XP_016862709.1
XP_016862710.1
XP_016862711.1
XP_016862717.1
XP_024309524.1
XP_024309528.1
XP_047304924.1
XP_047304926.1
XP_047304927.1
XP_047304928.1
XP_047304929.1
XP_047304930.1
XP_047304932.1
XP_047304933.1
XP_047304934.1
XP_047304935.1
XP_047304936.1
XP_054203894.1
XP_054203895.1
XP_054203896.1
XP_054203897.1
XP_054203898.1
XP_054203899.1
XP_054203900.1
XP_054203901.1
XP_054203902.1
XP_054203903.1
XP_054203904.1
XP_054203905.1
XP_054203906.1
XP_054203907.1
XP_054203908.1
XP_054203909.1
XP_054203910.1
XP_054203911.1
XP_054203912.1
XP_054203913.1
XP_054203914.1
XP_054203915.1
XP_054203916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029225.1 RefSeqGene

    Range
    5028..328616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146003.2NP_001139475.1  serine/threonine-protein kinase Nek11 isoform 3

    See identical proteins and their annotated locations for NP_001139475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS54639.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000423458.1, ENST00000510688.5
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  2. NM_001321220.2NP_001308149.1  serine/threonine-protein kinase Nek11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Related
    ENSP00000421851.1, ENST00000508196.5
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  3. NM_001321221.2NP_001308150.1  serine/threonine-protein kinase Nek11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB071996, AC116424, AK027148, AK297300, AL833472, BI032921, BX328072
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  4. NM_001321222.2NP_001308151.1  serine/threonine-protein kinase Nek11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS82837.1
    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Related
    ENSP00000421549.1, ENST00000510769.5
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001321223.1NP_001308152.1  serine/threonine-protein kinase Nek11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC028587, DB446413
    Consensus CDS
    CCDS82836.1
    UniProtKB/Swiss-Prot
    Q8NG66
    Related
    ENSP00000426662.1, ENST00000507910.5
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  6. NM_001321224.2NP_001308153.1  serine/threonine-protein kinase Nek11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK293261, AK297300, AL833472
    UniProtKB/TrEMBL
    B4DDN2
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001353022.2NP_001339951.1  serine/threonine-protein kinase Nek11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  8. NM_001353023.2NP_001339952.1  serine/threonine-protein kinase Nek11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  9. NM_001353024.2NP_001339953.1  serine/threonine-protein kinase Nek11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28286
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  10. NM_001353025.2NP_001339954.1  serine/threonine-protein kinase Nek11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28286
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  11. NM_001353026.2NP_001339955.1  serine/threonine-protein kinase Nek11 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  12. NM_001353027.2NP_001339956.1  serine/threonine-protein kinase Nek11 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  13. NM_001353028.2NP_001339957.1  serine/threonine-protein kinase Nek11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS54639.1
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  14. NM_001353029.2NP_001339958.1  serine/threonine-protein kinase Nek11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS54639.1
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  15. NM_001353030.2NP_001339959.1  serine/threonine-protein kinase Nek11 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  16. NM_001353031.2NP_001339960.1  serine/threonine-protein kinase Nek11 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  17. NM_001353032.2NP_001339961.1  serine/threonine-protein kinase Nek11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Consensus CDS
    CCDS82837.1
    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  18. NM_001353033.2NP_001339962.1  serine/threonine-protein kinase Nek11 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:7181
    PKc_like; Protein Kinases, catalytic domain
  19. NM_001353034.2NP_001339963.1  serine/threonine-protein kinase Nek11 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:7181
    PKc_like; Protein Kinases, catalytic domain
  20. NM_001353036.2NP_001339965.1  serine/threonine-protein kinase Nek11 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
  21. NM_001353037.2NP_001339966.1  serine/threonine-protein kinase Nek11 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001353038.2NP_001339967.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  23. NM_001353039.2NP_001339968.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  24. NM_001353040.2NP_001339969.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  25. NM_001353041.2NP_001339970.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  26. NM_001353042.2NP_001339971.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  27. NM_001353043.2NP_001339972.1  serine/threonine-protein kinase Nek11 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  28. NM_001353044.2NP_001339973.1  serine/threonine-protein kinase Nek11 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001353045.2NP_001339974.1  serine/threonine-protein kinase Nek11 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  30. NM_001353046.2NP_001339975.1  serine/threonine-protein kinase Nek11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC121332, CK903563
    UniProtKB/TrEMBL
    B4DDN2
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  31. NM_001353048.2NP_001339977.1  serine/threonine-protein kinase Nek11 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC010210, AC055733, AC083908, AC116424, AC121332, CK903563
    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  32. NM_024800.5NP_079076.3  serine/threonine-protein kinase Nek11 isoform 1

    See identical proteins and their annotated locations for NP_079076.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1), also known as NEK11L.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
    Related
    ENSP00000372857.4, ENST00000383366.9
    Conserved Domains (1) summary
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  33. NM_145910.4NP_665917.1  serine/threonine-protein kinase Nek11 isoform 2

    See identical proteins and their annotated locations for NP_665917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), also known as NEK11S, is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071997, AK297300, BU674219
    Consensus CDS
    CCDS46915.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000425114.1, ENST00000511262.5
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    131026877..131350465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007209.2XP_016862698.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  2. XM_047448971.1XP_047304927.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
  3. XM_017007206.2XP_016862695.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  4. XM_047448970.1XP_047304926.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
  5. XM_047448972.1XP_047304928.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/Swiss-Prot
    A6NHD7, Q5JPC0, Q8NG65, Q8NG66, Q8TBY1, Q9H5F4
    UniProtKB/TrEMBL
    B7ZAN7
  6. XM_047448974.1XP_047304930.1  serine/threonine-protein kinase Nek11 isoform X5

  7. XM_024453756.2XP_024309524.1  serine/threonine-protein kinase Nek11 isoform X6

    UniProtKB/TrEMBL
    B7ZAN7, E9PHI8
    Conserved Domains (1) summary
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  8. XM_047448977.1XP_047304933.1  serine/threonine-protein kinase Nek11 isoform X11

    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
  9. XM_017007208.2XP_016862697.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  10. XM_047448968.1XP_047304924.1  serine/threonine-protein kinase Nek11 isoform X2

  11. XM_047448973.1XP_047304929.1  serine/threonine-protein kinase Nek11 isoform X4

    UniProtKB/TrEMBL
    B7ZAN7
  12. XM_047448976.1XP_047304932.1  serine/threonine-protein kinase Nek11 isoform X11

    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
  13. XM_047448980.1XP_047304936.1  serine/threonine-protein kinase Nek11 isoform X15

  14. XM_017007221.2XP_016862710.1  serine/threonine-protein kinase Nek11 isoform X8

  15. XM_017007220.2XP_016862709.1  serine/threonine-protein kinase Nek11 isoform X7

  16. XM_047448978.1XP_047304934.1  serine/threonine-protein kinase Nek11 isoform X12

  17. XM_017007222.2XP_016862711.1  serine/threonine-protein kinase Nek11 isoform X9

  18. XM_047448979.1XP_047304935.1  serine/threonine-protein kinase Nek11 isoform X13

    Related
    ENSP00000349389.5, ENST00000356918.8
  19. XM_017007210.2XP_016862699.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  20. XM_017007207.2XP_016862696.1  serine/threonine-protein kinase Nek11 isoform X1

    Conserved Domains (1) summary
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  21. XM_011513174.2XP_011511476.1  serine/threonine-protein kinase Nek11 isoform X10

    See identical proteins and their annotated locations for XP_011511476.1

    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  22. XM_011513175.2XP_011511477.1  serine/threonine-protein kinase Nek11 isoform X10

    See identical proteins and their annotated locations for XP_011511477.1

    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  23. XM_017007228.2XP_016862717.1  serine/threonine-protein kinase Nek11 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  24. XM_024453760.2XP_024309528.1  serine/threonine-protein kinase Nek11 isoform X14

    Conserved Domains (2) summary
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
    cl25539
    Location:16223
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001740271.2 RNA Sequence

    Related
    ENST00000514915.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    133770580..134094242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347920.1XP_054203895.1  serine/threonine-protein kinase Nek11 isoform X1

  2. XM_054347925.1XP_054203900.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/TrEMBL
    B7ZAN7
  3. XM_054347927.1XP_054203902.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/TrEMBL
    B7ZAN7
  4. XM_054347929.1XP_054203904.1  serine/threonine-protein kinase Nek11 isoform X5

  5. XM_054347930.1XP_054203905.1  serine/threonine-protein kinase Nek11 isoform X6

    UniProtKB/TrEMBL
    B7ZAN7
  6. XM_054347937.1XP_054203912.1  serine/threonine-protein kinase Nek11 isoform X11

    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
  7. XM_054347922.1XP_054203897.1  serine/threonine-protein kinase Nek11 isoform X1

  8. XM_054347926.1XP_054203901.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/TrEMBL
    B7ZAN7
  9. XM_054347919.1XP_054203894.1  serine/threonine-protein kinase Nek11 isoform X1

  10. XM_054347924.1XP_054203899.1  serine/threonine-protein kinase Nek11 isoform X2

  11. XM_054347928.1XP_054203903.1  serine/threonine-protein kinase Nek11 isoform X4

    UniProtKB/TrEMBL
    B7ZAN7
  12. XM_054347936.1XP_054203911.1  serine/threonine-protein kinase Nek11 isoform X11

    UniProtKB/TrEMBL
    B4DM56, B7ZAN7
  13. XM_054347941.1XP_054203916.1  serine/threonine-protein kinase Nek11 isoform X15

  14. XM_054347932.1XP_054203907.1  serine/threonine-protein kinase Nek11 isoform X8

  15. XM_054347931.1XP_054203906.1  serine/threonine-protein kinase Nek11 isoform X7

  16. XM_054347938.1XP_054203913.1  serine/threonine-protein kinase Nek11 isoform X12

  17. XM_054347933.1XP_054203908.1  serine/threonine-protein kinase Nek11 isoform X9

  18. XM_054347939.1XP_054203914.1  serine/threonine-protein kinase Nek11 isoform X13

  19. XM_054347923.1XP_054203898.1  serine/threonine-protein kinase Nek11 isoform X1

  20. XM_054347921.1XP_054203896.1  serine/threonine-protein kinase Nek11 isoform X1

  21. XM_054347934.1XP_054203909.1  serine/threonine-protein kinase Nek11 isoform X10

  22. XM_054347935.1XP_054203910.1  serine/threonine-protein kinase Nek11 isoform X10

  23. XM_054347940.1XP_054203915.1  serine/threonine-protein kinase Nek11 isoform X14