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Nek11 NIMA (never in mitosis gene a)-related expressed kinase 11 [ Mus musculus (house mouse) ]

Gene ID: 208583, updated on 30-Apr-2024

Summary

Official Symbol
Nek11provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 11provided by MGI
Primary source
MGI:MGI:2442276
See related
Ensembl:ENSMUSG00000035032 AllianceGenome:MGI:2442276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932416N14Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation; histone phosphorylation; and regulation of cell cycle phase transition. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleolus. Predicted to be active in centrosome; cytoplasm; and nucleoplasm. Is expressed in several structures, including alimentary system; cartilage; central nervous system; genitourinary system; and respiratory system. Orthologous to human NEK11 (NIMA related kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.4), lung adult (RPKM 0.3) and 7 other tissues See more
Orthologs
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Genomic context

See Nek11 in Genome Data Viewer
Location:
9 F1; 9 56.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105039355..105272723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105162156..105395524, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E895 Neighboring gene STARR-positive B cell enhancer ABC_E3856 Neighboring gene STARR-positive B cell enhancer ABC_E5100 Neighboring gene asteroid homolog 1 Neighboring gene ATPase, Ca++-sequestering Neighboring gene STARR-positive B cell enhancer mm9_chr9:105398187-105398487 Neighboring gene predicted gene, 40564 Neighboring gene STARR-seq mESC enhancer starr_25124 Neighboring gene STARR-seq mESC enhancer starr_25126 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek11
Names
NIMA-related kinase 11
never in mitosis A-related kinase 11
nimA-related protein kinase 11
NP_766049.2
XP_006511742.1
XP_006511743.1
XP_006511745.1
XP_006511748.1
XP_006511749.1
XP_017168748.1
XP_030100034.1
XP_036010662.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172461.4NP_766049.2  serine/threonine-protein kinase Nek11

    See identical proteins and their annotated locations for NP_766049.2

    Status: VALIDATED

    Source sequence(s)
    AC113016, AC161250
    Consensus CDS
    CCDS23464.1
    UniProtKB/Swiss-Prot
    E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
    UniProtKB/TrEMBL
    Q0VDN9
    Related
    ENSMUSP00000038611.5, ENSMUST00000038648.11
    Conserved Domains (1) summary
    cd08222
    Location:29288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    105039355..105272723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154769.1XP_036010662.1  serine/threonine-protein kinase Nek11 isoform X7

    Conserved Domains (2) summary
    COG4913
    Location:63191
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:163
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030244174.2XP_030100034.1  serine/threonine-protein kinase Nek11 isoform X7

    Conserved Domains (2) summary
    COG4913
    Location:63191
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:163
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006511679.5XP_006511742.1  serine/threonine-protein kinase Nek11 isoform X1

    See identical proteins and their annotated locations for XP_006511742.1

    UniProtKB/Swiss-Prot
    E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cd08222
    Location:29288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  4. XM_006511682.4XP_006511745.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cl21453
    Location:1189
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017313259.2XP_017168748.1  serine/threonine-protein kinase Nek11 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006511686.4XP_006511749.1  serine/threonine-protein kinase Nek11 isoform X6

    Conserved Domains (2) summary
    COG4913
    Location:75203
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:575
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006511680.1XP_006511743.1  serine/threonine-protein kinase Nek11 isoform X2

    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cd08222
    Location:29288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  8. XM_006511685.2XP_006511748.1  serine/threonine-protein kinase Nek11 isoform X5

    UniProtKB/TrEMBL
    D3Z1E7
    Related
    ENSMUSP00000116864.2, ENSMUST00000140851.3
    Conserved Domains (1) summary
    cd08222
    Location:29288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RNA

  1. XR_003947831.1 RNA Sequence

  2. XR_379760.1 RNA Sequence

  3. XR_379761.3 RNA Sequence