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EPHX3 epoxide hydrolase 3 [ Homo sapiens (human) ]

Gene ID: 79852, updated on 23-Nov-2021

Summary

Official Symbol
EPHX3provided by HGNC
Official Full Name
epoxide hydrolase 3provided by HGNC
Primary source
HGNC:HGNC:23760
See related
Ensembl:ENSG00000105131 MIM:617400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EH3; ABHD9
Expression
Biased expression in skin (RPKM 21.8), esophagus (RPKM 15.1) and 1 other tissue See more
Orthologs
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Genomic context

See EPHX3 in Genome Data Viewer
Location:
19p13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15226919..15233453, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15337730..15343779, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 782, pseudogene Neighboring gene notch receptor 3 Neighboring gene microRNA 6795 Neighboring gene bromodomain containing 4 Neighboring gene Sharpr-MPRA regulatory region 9920 Neighboring gene A-kinase anchoring protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ22408, MGC131519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables epoxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in epoxide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
epoxide hydrolase 3
Names
abhydrolase domain containing 9
abhydrolase domain-containing protein 9
NP_001136358.1
NP_079070.1
XP_024307493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142886.2NP_001136358.1  epoxide hydrolase 3

    See identical proteins and their annotated locations for NP_001136358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5'UTR. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004257, BC115002, CD632298, DA378406
    Consensus CDS
    CCDS12327.1
    UniProtKB/Swiss-Prot
    Q9H6B9
    UniProtKB/TrEMBL
    A0A024R7F3
    Related
    ENSP00000410323.1, ENST00000435261.5
    Conserved Domains (1) summary
    COG0596
    Location:80351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
  2. NM_024794.3NP_079070.1  epoxide hydrolase 3

    See identical proteins and their annotated locations for NP_079070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5'UTR. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004257, AK026061, BC115002
    Consensus CDS
    CCDS12327.1
    UniProtKB/Swiss-Prot
    Q9H6B9
    UniProtKB/TrEMBL
    A0A024R7F3
    Related
    ENSP00000221730.2, ENST00000221730.8
    Conserved Domains (1) summary
    COG0596
    Location:80351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15226919..15233453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451725.1XP_024307493.1  epoxide hydrolase 3 isoform X1

    Related
    ENSP00000469345.1, ENST00000602233.5
    Conserved Domains (1) summary
    COG0596
    Location:80351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
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