NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|13376164|ref|NP_079070|]
View 

epoxide hydrolase 3 [Homo sapiens]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596 132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13376164 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596 185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596 132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13376164 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596 185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
81-347 8.07e-27

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 111.23  E-value: 8.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   81 KSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVIL 160
Cdd:PRK05855   9 SSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  161 GLGYSKCI-LVAHDWGALLAWHFsIYYPSLVERM---VVVSGaPmsvyqdySLHHI--------------------SQFF 216
Cdd:PRK05855  89 AVSPDRPVhLLAHDWGSIQGWEA-VTRPRAAGRIasfTSVSG-P-------SLDHVgfwlrsglrrptprrlaralGQLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  217 RSHYMFLFQLPWLPEKLLsmsdfqilkttlthrKTGIPCLTPSELEAfLYNFSQPGGLTGP--------LNYYR-NLFRN 287
Cdd:PRK05855 160 RSWYIYLFHLPVLPELLW---------------RLGLGRAWPRLLRR-VEGTPVDPIPTQTtlsdgahgVKLYRaNMIRS 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13376164  288 FpLEPQE--LTTPTLLLWGEKDTYLELGLVEAIgSRFVPgRLEAHILPGiGHWIPQSNPQEM 347
Cdd:PRK05855 224 L-SRPREryTDVPVQLIVPTGDPYVRPALYDDL-SRWVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 98-339 2.88e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.11  E-value: 2.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    98 PLMLFLHGFPENWFSWRYQLREFQ-SRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGA 176
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   177 LLAWHFSIYYPSLVERMVVVSGAPMSvyqdyslHHISQFFRshyMFLFQLPWLPEKLLSmSDFQILKTTLTHRKTGiPCL 256
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPP-------HELDEADR---FILALFPGFFDGFVA-DFAPNPLGRLVAKLLA-LLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   257 TPSELEAFLYNFS----------QPGGLTGPLNYYRNLFRNFPLEP-QELTTPTLLLWGEKDTYLELGLVEAIGSRFvPG 325
Cdd:pfam00561 149 LRLRLLKALPLLNkrfpsgdyalAKSLVTGALLFIETWSTELRAKFlGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PN 227

                         250
                  ....*....|....
gi 13376164   326 RLEAHILPGiGHWI 339
Cdd:pfam00561 228 ARLVVIPDA-GHFA 240
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 93-206 2.35e-03

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 39.03  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDcytidllLVDIKDVILGLGYSKCILVAH 172
Cdd:TIGR01738   1 GQGNVHLVL-IHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLS-------LADMAEAIAAQAPDPAIWLGW 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 13376164   173 DWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQD 206
Cdd:TIGR01738  73 SLGGLVALHIAATHPDRVRALVTVASSPCFSARE 106
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 80-358 2.83e-39

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 138.98  E-value: 2.83e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  80 LKSSGLRLHYVSAGRgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVdcYTIDLLLVDIKDVI 159
Cdd:COG0596   7 VTVDGVRLHYREAGP-DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGG--YTLDDLADDLAALL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvyqdyslhhiSQFFRSHYmflfqlpwlpekllsmsdf 239
Cdd:COG0596  84 DALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV-------------LAALAEPL------------------- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 240 qilkttlthrktGIPCLTPSELEAFLYNFSQPggltgplnyyrnlfrNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIG 319
Cdd:COG0596 132 ------------RRPGLAPEALAALLRALART---------------DLRERLARITVPTLVIWGEKDPIVPPALARRLA 184

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13376164 320 SRFvpGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:COG0596 185 ELL--PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK05855 PRK05855
SDR family oxidoreductase;
81-347 8.07e-27

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 111.23  E-value: 8.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   81 KSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVIL 160
Cdd:PRK05855   9 SSDGVRLAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  161 GLGYSKCI-LVAHDWGALLAWHFsIYYPSLVERM---VVVSGaPmsvyqdySLHHI--------------------SQFF 216
Cdd:PRK05855  89 AVSPDRPVhLLAHDWGSIQGWEA-VTRPRAAGRIasfTSVSG-P-------SLDHVgfwlrsglrrptprrlaralGQLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  217 RSHYMFLFQLPWLPEKLLsmsdfqilkttlthrKTGIPCLTPSELEAfLYNFSQPGGLTGP--------LNYYR-NLFRN 287
Cdd:PRK05855 160 RSWYIYLFHLPVLPELLW---------------RLGLGRAWPRLLRR-VEGTPVDPIPTQTtlsdgahgVKLYRaNMIRS 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13376164  288 FpLEPQE--LTTPTLLLWGEKDTYLELGLVEAIgSRFVPgRLEAHILPGiGHWIPQSNPQEM 347
Cdd:PRK05855 224 L-SRPREryTDVPVQLIVPTGDPYVRPALYDDL-SRWVP-RLWRREIKA-GHWLPMSHPQVL 281
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 98-339 2.88e-22

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.11  E-value: 2.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    98 PLMLFLHGFPENWFSWRYQLREFQ-SRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGA 176
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   177 LLAWHFSIYYPSLVERMVVVSGAPMSvyqdyslHHISQFFRshyMFLFQLPWLPEKLLSmSDFQILKTTLTHRKTGiPCL 256
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPP-------HELDEADR---FILALFPGFFDGFVA-DFAPNPLGRLVAKLLA-LLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   257 TPSELEAFLYNFS----------QPGGLTGPLNYYRNLFRNFPLEP-QELTTPTLLLWGEKDTYLELGLVEAIGSRFvPG 325
Cdd:pfam00561 149 LRLRLLKALPLLNkrfpsgdyalAKSLVTGALLFIETWSTELRAKFlGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PN 227

                         250
                  ....*....|....
gi 13376164   326 RLEAHILPGiGHWI 339
Cdd:pfam00561 228 ARLVVIPDA-GHFA 240
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
82-357 1.55e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 68.88  E-value: 1.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  82 SSGLRLHYVS--AGRGNGPLMLFLHGFPENWFSWRYQLREFQSR-FHVVAVDLRGYGPSDAPRdVDCYTIDLLLVDIKDV 158
Cdd:COG2267  11 RDGLRLRGRRwrPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPR-GHVDSFDDYVDDLRAA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 159 I---LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGApmsvYQDYSLHHISQffrshymflfqlPWLpeklls 235
Cdd:COG2267  90 LdalRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA----YRADPLLGPSA------------RWL------ 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 236 mSDFQILKttlthrktgipcltpseleaflynfsqpggltgplnyyrnlfrnfplEPQELTTPTLLLWGEKDTYLELGLV 315
Cdd:COG2267 148 -RALRLAE-----------------------------------------------ALARIDVPVLVLHGGADRVVPPEAA 179

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13376164 316 EAIGSRFVPgRLEAHILPGIGHWIPQS-NPQEMHQYMWAFLQD 357
Cdd:COG2267 180 RRLAARLSP-DVELVLLPGARHELLNEpAREEVLAAILAWLER 221
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 84-358 3.17e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 66.17  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   84 GLRLHYVSAGrgNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAP----------RDVDCYtIDLLlv 153
Cdd:PRK03592  16 GSRMAYIETG--EGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKPdidytfadhaRYLDAW-FDAL-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  154 DIKDVilglgyskcILVAHDWGALLAWHFSIYYPSLVERMVVVSGA--PMSvYQDYSLH--HISQFFRSH---YMFLFQL 226
Cdd:PRK03592  91 GLDDV---------VLVGHDWGSALGFDWAARHPDRVRGIAFMEAIvrPMT-WDDFPPAvrELFQALRSPgegEEMVLEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  227 PWLPEKLLSMSdfqILKTtlthrktgipcLTPSELEAFLYNFSQPGG----LTGPlnyyrnlfRNFPL--EPQE------ 294
Cdd:PRK03592 161 NVFIERVLPGS---ILRP-----------LSDEEMAVYRRPFPTPESrrptLSWP--------RELPIdgEPADvvalve 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13376164  295 -----LTT---PTLLLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPGiGHWIPQSNPQEMHQYMWAFLQDL 358
Cdd:PRK03592 219 eyaqwLATsdvPKLLINAEPGAILTTGAIRDWCRSWPNQLEITVFGAG-LHFAQEDSPEEIGAAIAAWLRRL 289
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 85-195 7.27e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 65.37  E-value: 7.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   85 LRLHYVSAGRGNGPLMLFLHGFPenwfSWRYQLRE----FQSRFH-VVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVI 159
Cdd:PRK00870  34 LRMHYVDEGPADGPPVLLLHGEP----SWSYLYRKmipiLAAAGHrVIAPDLIGFGRSDKPTRREDYTYARHVEWMRSWF 109

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 13376164  160 LGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVV 195
Cdd:PRK00870 110 EQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVV 145
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
82-359 1.29e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 63.88  E-value: 1.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  82 SSGLRLH---YVSAGRGNGPLMLFLHGFPEN-WFSWRYQLREFQSR-FHVVAVDLRGYGPSDAprdvdcytiDLLLVDIK 156
Cdd:COG1506   5 ADGTTLPgwlYLPADGKKYPVVVYVHGGPGSrDDSFLPLAQALASRgYAVLAPDYRGYGESAG---------DWGGDEVD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 157 DVILGLGY---------SKCILVAHDWGALLAWHFSIYYPSLVErmVVVSGAPMSVYQDYSlhHISQFFRSHYMFlfqlp 227
Cdd:COG1506  76 DVLAAIDYlaarpyvdpDRIGIYGHSYGGYMALLAAARHPDRFK--AAVALAGVSDLRSYY--GTTREYTERLMG----- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164 228 wlpekllsmsdfqilkttlthrktgipclTPSELEAFLYNFSqpggltgPLNYYRNlfrnfplepqeLTTPTLLLWGEKD 307
Cdd:COG1506 147 -----------------------------GPWEDPEAYAARS-------PLAYADK-----------LKTPLLLIHGEAD 179

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13376164 308 TYLELG----LVEAIGSRFVPGRLeaHILPGIGHWIPQSNPQEMHQYMWAFLQDLL 359
Cdd:COG1506 180 DRVPPEqaerLYEALKKAGKPVEL--LVYPGEGHGFSGAGAPDYLERILDFLDRHL 233
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 82-347 1.44e-09

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 58.33  E-value: 1.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   82 SSGLRLHYVSagRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPrDVDCYTIDLLLVDIKDVILG 161
Cdd:PRK03204  21 SSRGRIHYID--EGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERP-SGFGYQIDEHARVIGEFVDH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  162 LGYSKCILVAHDWGAllawhfSIYYPSLVERMVVVSGApmsVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDF-- 239
Cdd:PRK03204  98 LGLDRYLSMGQDWGG------PISMAVAVERADRVRGV---VLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFve 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  240 QILKTTLTHRktgipcltPSELEAFLYNFSQPGG--------LTGPLNYYRNLFRNFPLE-PQEL-TTPTLLLWGEKDTY 309
Cdd:PRK03204 169 RLIPAGTEHR--------PSSAVMAHYRAVQPNAaarrgvaeMPKQILAARPLLARLAREvPATLgTKPTLLVWGMKDVA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 13376164  310 LElglVEAIGSRF--VPGRLEAHILPGIGHWIPQSNPQEM 347
Cdd:PRK03204 241 FR---PKTILPRLraTFPDHVLVELPNAKHFIQEDAPDRI 277
PLN02578 PLN02578
hydrolase
 84-199 3.18e-08

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 54.85  E-value: 3.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   84 GLRLHYVSAGRGNgPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDapRDVDCYTIDLLLVDIKDVILGLG 163
Cdd:PLN02578  75 GHKIHYVVQGEGL-PIVL-IHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSD--KALIEYDAMVWRDQVADFVKEVV 150

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 13376164  164 YSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGA 199
Cdd:PLN02578 151 KEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNSA 186
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 100-347 4.55e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 52.86  E-value: 4.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   100 MLFLHGFpenWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRdvdcYTIDlLLVDIKDVILGLGYSK-CILVAHDWGALL 178
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPP----LDLA-DLADLAALLDELGAARpVVLVGHSLGGAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   179 AWHFSIYYPslVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDFQILKTTLTHRktgipcltp 258
Cdd:pfam12697  73 ALAAAAAAL--VVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALA--------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   259 seleaflynfsqpggltgPLNYYRNLFRNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIGSRfvpGRLEAHILPGIGHW 338
Cdd:pfam12697 142 ------------------RLAALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAAL---AGARLVVLPGAGHL 200


                  ....*....
gi 13376164   339 iPQSNPQEM 347
Cdd:pfam12697 201 -PLDDPEEV 208
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 84-347 5.06e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 53.59  E-value: 5.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   84 GLRLHYVSAGrGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDA--PRDV---DCYTIDLLLVDIKDV 158
Cdd:PLN02824  17 GYNIRYQRAG-TSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKpnPRSAppnSFYTFETWGEQLNDF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  159 ILGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVsgapmsvyqDYSLH--HIS--QFFRSHYMFLFQlPWLPEKLL 234
Cdd:PLN02824  96 CSDVVGDPAFVICNSVGGVVGLQAAVDAPELVRGVMLI---------NISLRglHIKkqPWLGRPFIKAFQ-NLLRETAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  235 SMSDFQILKTTLTHRKTGIPC------LTPSELEAFLYNFSQPGGLtgplnyyrNLFRNF------PLePQEL----TTP 298
Cdd:PLN02824 166 GKAFFKSVATPETVKNILCQCyhddsaVTDELVEAILRPGLEPGAV--------DVFLDFisysggPL-PEELlpavKCP 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 13376164  299 TLLLWGEKDTYLELGLVEAIGS-----RFVPgrleahiLPGIGHwIPQSNPQEM 347
Cdd:PLN02824 237 VLIAWGEKDPWEPVELGRAYANfdaveDFIV-------LPGVGH-CPQDEAPEL 282
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 86-140 1.43e-07

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 52.58  E-value: 1.43e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13376164   86 RLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAP 140
Cdd:PLN03084 116 RWFCVESGSNNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKP 170
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 99-337 2.55e-07

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 51.06  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    99 LMLFLHGFpeNWFSWRYQL--REFQSR-FHVVAVDLRGYGPSDAPR----DVDCYTIDLLLVdIKDVILGLGYSKCILVA 171
Cdd:pfam12146   6 VVVLVHGL--GEHSGRYAHlaDALAAQgFAVYAYDHRGHGRSDGKRghvpSFDDYVDDLDTF-VDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   172 HDWGALLAWHFSIYYPSLVERMVVVsgAPMSVYQDYSLHHISQFFrsHYMFLFQLPWLPEKLlsmsdfQILKTTLTHRkt 251
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILS--APALKIKPYLAPPILKLL--AKLLGKLFPRLRVPN------NLLPDSLSRD-- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   252 gipcltPSELEAFlYNFSQPGGLTgPLNYYRNLFR--NFPLEP-QELTTPTLLLWGEKDTYLELG----LVEAIGSRfvp 324
Cdd:pfam12146 151 ------PEVVAAY-AADPLVHGGI-SARTLYELLDagERLLRRaAAITVPLLLLHGGADRVVDPAgsreFYERAGST--- 219

                         250
                  ....*....|...
gi 13376164   325 gRLEAHILPGIGH 337
Cdd:pfam12146 220 -DKTLKLYPGLYH 231
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 85-344 7.88e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 44.85  E-value: 7.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    85 LRLHYVSAgRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSD----APRDVDCYTIDLLLVdiKDVIL 160
Cdd:PLN02980 1360 IKVHEVGQ-NAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSKiqnhAKETQTEPTLSVELV--ADLLY 1436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   161 GLGYS----KCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAP---------MSVYQDYSLhhiSQFFRSHYMFLFQLP 227
Cdd:PLN02980 1437 KLIEHitpgKVTLVGYSMGARIALYMALRFSDKIEGAVIISGSPglkdevarkIRSAKDDSR---ARMLIDHGLEIFLEN 1513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   228 W----LPEKLLSMSDF-QILKTTLTHRKtgIPCLtpSELEAFLYNFSQPggltgplnyyrnlfrnfPL--EPQELTTPTL 300
Cdd:PLN02980 1514 WysgeLWKSLRNHPHFnKIVASRLLHKD--VPSL--AKLLSDLSIGRQP-----------------SLweDLKQCDTPLL 1572

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 13376164   301 LLWGEKDT---------YLELGLVEAIGSRFVPGRLEAHILPGIGHWIPQSNP 344
Cdd:PLN02980 1573 LVVGEKDVkfkqiaqkmYREIGKSKESGNDKGKEIIEIVEIPNCGHAVHLENP 1625
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 93-348 1.16e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 43.75  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   93 GRGNGPLMLFLHGFPEnwfSWRYQLREFQ---SRFHVVAVDLRGYGPSDAPrDVDCYTI----DLLLVDIKDVILGLGYS 165
Cdd:PLN02894 101 SKEDAPTLVMVHGYGA---SQGFFFRNFDalaSRFRVIAIDQLGWGGSSRP-DFTCKSTeeteAWFIDSFEEWRKAKNLS 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  166 KCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPW----LPEKLLSMSD--- 238
Cdd:PLN02894 177 NFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEWLTKFRATWKGAVLNHLWesnfTPQKIIRGLGpwg 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  239 ----FQILKTTLTHRKTGIPcLTPSEL----EAFLYNFSQPGGLTGPLNYYRNL--FRNFPLEPQ--ELTTPTLLLWGEK 306
Cdd:PLN02894 257 pnlvRRYTTARFGAHSTGDI-LSEEESklltDYVYHTLAAKASGELCLKYIFSFgaFARKPLLESasEWKVPTTFIYGRH 335

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 13376164  307 DTYLELGLVEAIGSRFVPGRLEahILPGIGHWIPQSNPQEMH 348
Cdd:PLN02894 336 DWMNYEGAVEARKRMKVPCEII--RVPQGGHFVFLDNPSGFH 375
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
93-200 2.24e-04

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 42.31  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAprdvdcyTIDLLLVDIKDVILGLGYSKCILVAH 172
Cdd:PRK10349  10 GQGNVHLVL-LHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRG-------FGALSLADMAEAVLQQAPDKAIWLGW 81

                         90       100
                 ....*....|....*....|....*...
gi 13376164  173 DWGALLAWHFSIYYPSLVERMVVVSGAP 200
Cdd:PRK10349  82 SLGGLVASQIALTHPERVQALVTVASSP 109
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 101-200 1.81e-03

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 40.18  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  101 LFLHGFPENWFSWRYQL-----REFQSRFHVVAVDLRGYGPSDAPRDvDCYTIDLLLVDI-KDVILGLGYSKCILVAHDW 174
Cdd:PLN03087 205 LFIHGFISSSAFWTETLfpnfsDAAKSTYRLFAVDLLGFGRSPKPAD-SLYTLREHLEMIeRSVLERYKVKSFHIVAHSL 283

                         90       100
                 ....*....|....*....|....*.
gi 13376164  175 GALLAWHFSIYYPSLVERMVVVsgAP 200
Cdd:PLN03087 284 GCILALALAVKHPGAVKSLTLL--AP 307
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 93-206 2.35e-03

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 39.03  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164    93 GRGNGPLMLfLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDcytidllLVDIKDVILGLGYSKCILVAH 172
Cdd:TIGR01738   1 GQGNVHLVL-IHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLS-------LADMAEAIAAQAPDPAIWLGW 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 13376164   173 DWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQD 206
Cdd:TIGR01738  73 SLGGLVALHIAATHPDRVRALVTVASSPCFSARE 106
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 84-159 3.05e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 38.74  E-value: 3.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164  84 GLRLH---YVSAGRGNG-PLMLFLHGFPENWFSWRYQLREFQSR-FHVVAVDLRGYGPSD-APRDVDCYTIDlllvDIKD 157
Cdd:COG1073  20 GIKLAgdlYLPAGASKKyPAVVVAHGNGGVKEQRALYAQRLAELgFNVLAFDYRGYGESEgEPREEGSPERR----DARA 95


                ..
gi 13376164 158 VI 159
Cdd:COG1073  96 AV 97
PRK08775 PRK08775
homoserine O-succinyltransferase;
85-205 5.57e-03

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 38.23  E-value: 5.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376164   85 LRLHYVSAGRGNGPLMLFLHG------------FPEN-WfsWRYQLREFQ----SRFHVVAVDLRGygpSDAPRDVDCYT 147
Cdd:PRK08775  46 LRLRYELIGPAGAPVVFVAGGisahrhvaatatFPEKgW--WEGLVGSGRaldpARFRLLAFDFIG---ADGSLDVPIDT 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13376164  148 ID-----LLLVDIkdviLGLGYSKCIlVAHDWGALLAWHFSIYYPSLVERMVVVSGA----PMSVYQ 205
Cdd:PRK08775 121 ADqadaiALLLDA----LGIARLHAF-VGYSYGALVGLQFASRHPARVRTLVVVSGAhrahPYAAAW 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH