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Ephx3 epoxide hydrolase 3 [ Mus musculus (house mouse) ]

Gene ID: 71932, updated on 5-Mar-2024

Summary

Official Symbol
Ephx3provided by MGI
Official Full Name
epoxide hydrolase 3provided by MGI
Primary source
MGI:MGI:1919182
See related
Ensembl:ENSMUSG00000037577 AllianceGenome:MGI:1919182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EH3; Abhd9; 2310063B19Rik
Summary
Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 8.4), lung adult (RPKM 2.9) and 6 other tissues See more
Orthologs
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Genomic context

See Ephx3 in Genome Data Viewer
Location:
17 B1; 17 17.39 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32402742..32408444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32183770..32189470, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38585 Neighboring gene notch 3 Neighboring gene predicted gene, 41568 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32301287-32301488 Neighboring gene VISTA enhancer mm1733 Neighboring gene bromodomain containing 4 Neighboring gene predicted gene 4432 Neighboring gene STARR-positive B cell enhancer ABC_E11795 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epoxide hydrolase 3
Names
abhydrolase domain-containing protein 9
NP_001028335.1
NP_001334270.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033163.4NP_001028335.1  epoxide hydrolase 3 isoform 1

    See identical proteins and their annotated locations for NP_001028335.1

    Status: VALIDATED

    Source sequence(s)
    CT033755
    Consensus CDS
    CCDS28615.1
    UniProtKB/TrEMBL
    A0A0R4J127, A6H695
    Related
    ENSMUSP00000085013.4, ENSMUST00000087721.10
    Conserved Domains (2) summary
    COG0596
    Location:144415
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:139262
    Abhydrolase; alpha/beta hydrolases
  2. NM_001347341.2NP_001334270.1  epoxide hydrolase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT033755
    Consensus CDS
    CCDS84290.1
    UniProtKB/TrEMBL
    A6H695, G3XA19
    Related
    ENSMUSP00000124600.2, ENSMUST00000162117.3

RNA

  1. NR_175782.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT033755

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32402742..32408444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)