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CSPP1 centrosome and spindle pole associated protein 1 [ Homo sapiens (human) ]

Gene ID: 79848, updated on 8-Feb-2025

Summary

Official Symbol
CSPP1provided by HGNC
Official Full Name
centrosome and spindle pole associated protein 1provided by HGNC
Primary source
HGNC:HGNC:26193
See related
Ensembl:ENSG00000104218 MIM:611654; AllianceGenome:HGNC:26193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSPP; CSPP-L; JBTS21
Summary
This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Expression
Broad expression in testis (RPKM 7.4), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See CSPP1 in Genome Data Viewer
Location:
8q13.1-q13.2
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (67064368..67196614)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (67488869..67623074)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67976603..68108849)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27495 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67976583-67976770 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:68012735-68012945 Neighboring gene COP9 signalosome subunit 5 Neighboring gene RNA, 5S ribosomal pseudogene 268 Neighboring gene uncharacterized LOC124901956 Neighboring gene ARF guanine nucleotide exchange factor 1 Neighboring gene nucleophosmin 1 pseudogene 44 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:68153855-68154652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68221915-68222570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68222571-68223225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:68255030-68255710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:68261316-68261816 Neighboring gene ARFGEF1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 12286 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1934 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68280925-68281630 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68281631-68282336 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:68293145-68293756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27499 Neighboring gene ribosomal protein L17 pseudogene 31 Neighboring gene carboxypeptidase A6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:68424545-68425147 Neighboring gene uncharacterized LOC105375886 Neighboring gene NACA pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of centrosome and spindle pole associated protein 1 (CSPP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22490, FLJ38886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrosome and spindle pole-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034100.1 RefSeqGene

    Range
    5025..137247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291339.2NP_001278268.1  centrosome and spindle pole-associated protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, and lacks an in-frame portion of the 5' coding region and an internal in-frame exon, compared to variant 1. The resulting isoform (2, also known as CSPP) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AJ583433, AK026143, AK308372, AM156947, CA447290, DB030075
    Consensus CDS
    CCDS78344.1
    UniProtKB/TrEMBL
    A0A7I2V5P5
    Related
    ENSP00000430092.1, ENST00000519668.1
  2. NM_001363131.2NP_001350060.1  centrosome and spindle pole-associated protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087359, AC109335, CA447290, DA177690
    Consensus CDS
    CCDS94309.1
    UniProtKB/TrEMBL
    A0A6Q8PF96, A0A7I2V4L2
    Related
    ENSP00000501676.1, ENST00000675955.1
  3. NM_001363132.2NP_001350061.1  centrosome and spindle pole-associated protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AM156947, BG698003, BM555375, BX649147, CA447290, DB046430, DW426634, HY040643
    Consensus CDS
    CCDS94308.1
    UniProtKB/TrEMBL
    A0A6Q8PF61, A0A6Q8PHN8
    Related
    ENSP00000502747.1, ENST00000675869.1
  4. NM_001363133.2NP_001350062.1  centrosome and spindle pole-associated protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC087359, BG698003, BM555375, CA447290, DA177690
    Consensus CDS
    CCDS94310.1
    UniProtKB/TrEMBL
    A0A6Q8PGS3, A0A7I2V3M9
    Related
    ENSP00000502421.1, ENST00000675306.2
  5. NM_001364869.1NP_001351798.1  centrosome and spindle pole-associated protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC087359, AC109335
    Consensus CDS
    CCDS94301.1
    UniProtKB/TrEMBL
    A0A7I2PHE7, A0A7I2V372
    Related
    ENSP00000262210.6, ENST00000262210.11
  6. NM_001364870.1NP_001351799.1  centrosome and spindle pole-associated protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC087359, AC109335
    Consensus CDS
    CCDS94304.1
    UniProtKB/TrEMBL
    A0A7I2V372, A0A7I2V5L8
    Related
    ENSP00000504342.1, ENST00000676882.1
  7. NM_001382391.1NP_001369320.1  centrosome and spindle pole-associated protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC087359, AC109335
    Consensus CDS
    CCDS94307.1
    UniProtKB/TrEMBL
    A0A6Q8PF61, A0A7I2V5W3
    Related
    ENSP00000504733.1, ENST00000678616.1
  8. NM_024790.6NP_079066.5  centrosome and spindle pole-associated protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as CSPP-L).
    Source sequence(s)
    AM156947, BX649147, CA447290
    Consensus CDS
    CCDS43744.1
    UniProtKB/TrEMBL
    A0A7I2V372
    Related
    ENSP00000502047.1, ENST00000676317.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    67064368..67196614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517598.3XP_011515900.2  centrosome and spindle pole-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A7I2V372
  2. XM_047422253.1XP_047278209.1  centrosome and spindle pole-associated protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A7I2V398
  3. XM_047422245.1XP_047278201.1  centrosome and spindle pole-associated protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A7I2V372
  4. XM_047422257.1XP_047278213.1  centrosome and spindle pole-associated protein 1 isoform X20

    UniProtKB/TrEMBL
    A0A7I2V398
  5. XM_005251305.5XP_005251362.3  centrosome and spindle pole-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A6ND63, Q1MSJ5, Q70F00, Q8TBC1
    UniProtKB/TrEMBL
    A0A7I2V372
    Related
    ENSP00000502454.1, ENST00000674993.1
  6. XM_047422254.1XP_047278210.1  centrosome and spindle pole-associated protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A7I2V398
  7. XM_006716474.4XP_006716537.3  centrosome and spindle pole-associated protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A7I2V372
  8. XM_047422244.1XP_047278200.1  centrosome and spindle pole-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V372
  9. XM_017013847.3XP_016869336.2  centrosome and spindle pole-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A7I2V372
  10. XM_006716477.4XP_006716540.3  centrosome and spindle pole-associated protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A7I2V3F0
  11. XM_011517599.3XP_011515901.2  centrosome and spindle pole-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A7I2V372, A0A7I2V4R5
    Related
    ENSP00000503878.1, ENST00000678542.1
  12. XM_047422249.1XP_047278205.1  centrosome and spindle pole-associated protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A7I2V372
  13. XM_047422246.1XP_047278202.1  centrosome and spindle pole-associated protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A7I2V372, A0A7I2V5N5
    Related
    ENSP00000504516.1, ENST00000677592.1
  14. XM_017013854.3XP_016869343.2  centrosome and spindle pole-associated protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A7I2V3F0, A0A7I2YQH9
    Related
    ENSP00000503690.1, ENST00000678318.1
  15. XM_047422260.1XP_047278216.1  centrosome and spindle pole-associated protein 1 isoform X25

    UniProtKB/TrEMBL
    A0A7I2V3F0
  16. XM_011517601.3XP_011515903.2  centrosome and spindle pole-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A7I2V372
  17. XM_047422256.1XP_047278212.1  centrosome and spindle pole-associated protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A7I2V398
    Related
    ENSP00000503297.1, ENST00000677009.1
  18. XM_047422252.1XP_047278208.1  centrosome and spindle pole-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A7I2V372
  19. XM_017013849.3XP_016869338.2  centrosome and spindle pole-associated protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A7I2V372
  20. XM_047422255.1XP_047278211.1  centrosome and spindle pole-associated protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A7I2V372, A0A7I2V3Z9
    Related
    ENSP00000503711.1, ENST00000676471.1
  21. XM_047422259.1XP_047278215.1  centrosome and spindle pole-associated protein 1 isoform X24

    UniProtKB/TrEMBL
    A0A7I2V5G7
    Related
    ENSP00000504522.1, ENST00000677619.1
  22. XM_047422261.1XP_047278217.1  centrosome and spindle pole-associated protein 1 isoform X26

    UniProtKB/TrEMBL
    A0A7I2V5G7, A0A7I2V5J9
    Related
    ENSP00000504532.1, ENST00000676573.1
  23. XM_047422250.1XP_047278206.1  centrosome and spindle pole-associated protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A7I2V398
  24. XM_047422247.1XP_047278203.1  centrosome and spindle pole-associated protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A7I2V398
  25. XM_047422258.1XP_047278214.1  centrosome and spindle pole-associated protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A7I2V398
  26. XM_047422251.1XP_047278207.1  centrosome and spindle pole-associated protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A6Q8PF61
  27. XM_047422262.1XP_047278218.1  centrosome and spindle pole-associated protein 1 isoform X27

    UniProtKB/TrEMBL
    A0A7I2V5P5
  28. XM_011517611.4XP_011515913.1  centrosome and spindle pole-associated protein 1 isoform X28

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    67488869..67623074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361254.1XP_054217229.1  centrosome and spindle pole-associated protein 1 isoform X32

    UniProtKB/TrEMBL
    A0A7I2V372
  2. XM_054361267.1XP_054217242.1  centrosome and spindle pole-associated protein 1 isoform X35

    UniProtKB/TrEMBL
    A0A7I2V398
  3. XM_054361263.1XP_054217238.1  centrosome and spindle pole-associated protein 1 isoform X34

    UniProtKB/TrEMBL
    A0A7I2V372
  4. XM_054361250.1XP_054217225.1  centrosome and spindle pole-associated protein 1 isoform X30

    UniProtKB/TrEMBL
    A0A7I2V372
  5. XM_054361260.1XP_054217235.1  centrosome and spindle pole-associated protein 1 isoform X33

    UniProtKB/TrEMBL
    A0A7I2V372
  6. XM_054361247.1XP_054217222.1  centrosome and spindle pole-associated protein 1 isoform X29

    UniProtKB/TrEMBL
    A0A7I2V372
  7. XM_054361252.1XP_054217227.1  centrosome and spindle pole-associated protein 1 isoform X31

    UniProtKB/TrEMBL
    A0A7I2V372
  8. XM_054361264.1XP_054217239.1  centrosome and spindle pole-associated protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A7I2V398
  9. XM_054361255.1XP_054217230.1  centrosome and spindle pole-associated protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A7I2V372
  10. XM_054361268.1XP_054217243.1  centrosome and spindle pole-associated protein 1 isoform X20

    UniProtKB/TrEMBL
    A0A7I2V398
  11. XM_054361249.1XP_054217224.1  centrosome and spindle pole-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A7I2V372
  12. XM_054361265.1XP_054217240.1  centrosome and spindle pole-associated protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A7I2V398
  13. XM_054361257.1XP_054217232.1  centrosome and spindle pole-associated protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A7I2V372
  14. XM_054361251.1XP_054217226.1  centrosome and spindle pole-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V372
  15. XM_054361253.1XP_054217228.1  centrosome and spindle pole-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A7I2V372
  16. XM_054361269.1XP_054217244.1  centrosome and spindle pole-associated protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A7I2V3F0
  17. XM_054361248.1XP_054217223.1  centrosome and spindle pole-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A7I2V372
  18. XM_054361256.1XP_054217231.1  centrosome and spindle pole-associated protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A7I2V372
  19. XM_054361270.1XP_054217245.1  centrosome and spindle pole-associated protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A7I2V3F0
  20. XM_054361273.1XP_054217248.1  centrosome and spindle pole-associated protein 1 isoform X25

    UniProtKB/TrEMBL
    A0A7I2V3F0
  21. XM_054361258.1XP_054217233.1  centrosome and spindle pole-associated protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A7I2V372
  22. XM_054361266.1XP_054217241.1  centrosome and spindle pole-associated protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A7I2V372
  23. XM_054361272.1XP_054217247.1  centrosome and spindle pole-associated protein 1 isoform X24

    UniProtKB/TrEMBL
    A0A7I2V5G7
  24. XM_054361274.1XP_054217249.1  centrosome and spindle pole-associated protein 1 isoform X26

    UniProtKB/TrEMBL
    A0A7I2V5G7
  25. XM_054361261.1XP_054217236.1  centrosome and spindle pole-associated protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A7I2V398
  26. XM_054361259.1XP_054217234.1  centrosome and spindle pole-associated protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A7I2V398
  27. XM_054361271.1XP_054217246.1  centrosome and spindle pole-associated protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A7I2V398
  28. XM_054361262.1XP_054217237.1  centrosome and spindle pole-associated protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A6Q8PF61
  29. XM_054361275.1XP_054217250.1  centrosome and spindle pole-associated protein 1 isoform X27

    UniProtKB/TrEMBL
    A0A7I2V5P5
  30. XM_054361276.1XP_054217251.1  centrosome and spindle pole-associated protein 1 isoform X28

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077204.1: Suppressed sequence

    Description
    NM_001077204.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.