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Cspp1 centrosome and spindle pole associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 211660, updated on 30-Apr-2024

Summary

Official Symbol
Cspp1provided by MGI
Official Full Name
centrosome and spindle pole associated protein 1provided by MGI
Primary source
MGI:MGI:2681832
See related
Ensembl:ENSMUSG00000056763 AllianceGenome:MGI:2681832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cspp2; Cspp3; 2310020J12Rik; 4930413O22Rik
Summary
Predicted to be involved in positive regulation of cytokinesis. Located in spindle pole. Is expressed in several structures, including adrenal gland; central nervous system; gonad; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in Joubert syndrome 21. Orthologous to human CSPP1 (centrosome and spindle pole associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.3), CNS E14 (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See Cspp1 in Genome Data Viewer
Location:
1 A2; 1 2.3 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (10108194..10206996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (10038116..10136771)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00178 Neighboring gene STARR-seq mESC enhancer starr_00179 Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene transcription factor 24 Neighboring gene STARR-positive B cell enhancer ABC_E270 Neighboring gene predicted gene, 24674 Neighboring gene STARR-seq mESC enhancer starr_00181 Neighboring gene COP9 signalosome subunit 5 Neighboring gene STARR-seq mESC enhancer starr_00182 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene carboxypeptidase A6 Neighboring gene STARR-seq mESC enhancer starr_00185 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centrosome and spindle pole associated protein 1
Names
centrosome/spindle pole-associated protein 2
centrosome/spindle pole-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368816.1NP_001355745.1  centrosome and spindle pole associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102570, AC159972
    Consensus CDS
    CCDS87812.1
    Related
    ENSMUSP00000139775.2, ENSMUST00000186294.7
    Conserved Domains (1) summary
    pfam13904
    Location:569693
    DUF4207; Domain of unknown function (DUF4207)
  2. NM_026493.3NP_080769.3  centrosome and spindle pole associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080769.3

    Status: VALIDATED

    Source sequence(s)
    AC102570, AC159972, BB042416, BE943955, BM949181, BP768397, CN457021, CN459376, CO426461
    Consensus CDS
    CCDS35511.1
    UniProtKB/Swiss-Prot
    B2RX88
    Related
    ENSMUSP00000068804.6, ENSMUST00000071087.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    10108194..10206996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163249.1XP_036019142.1  centrosome and spindle pole associated protein 1 isoform X1

  2. XM_036163256.1XP_036019149.1  centrosome and spindle pole associated protein 1 isoform X4

  3. XM_006495479.5XP_006495542.3  centrosome and spindle pole associated protein 1 isoform X3

  4. XM_006495481.5XP_006495544.3  centrosome and spindle pole associated protein 1 isoform X5

    Conserved Domains (1) summary
    pfam13904
    Location:653776
    DUF4207; Domain of unknown function (DUF4207)
  5. XM_036163286.1XP_036019179.1  centrosome and spindle pole associated protein 1 isoform X18

  6. XM_006495485.4XP_006495548.3  centrosome and spindle pole associated protein 1 isoform X13

  7. XM_030252691.1XP_030108551.1  centrosome and spindle pole associated protein 1 isoform X15

    Conserved Domains (1) summary
    pfam13904
    Location:481604
    DUF4207; Domain of unknown function (DUF4207)
  8. XM_036163251.1XP_036019144.1  centrosome and spindle pole associated protein 1 isoform X2

  9. XM_030252675.1XP_030108535.1  centrosome and spindle pole associated protein 1 isoform X7

    Conserved Domains (1) summary
    pfam13904
    Location:645768
    DUF4207; Domain of unknown function (DUF4207)
  10. XM_030252689.1XP_030108549.1  centrosome and spindle pole associated protein 1 isoform X14

  11. XM_036163261.1XP_036019154.1  centrosome and spindle pole associated protein 1 isoform X6

  12. XM_006495482.5XP_006495545.1  centrosome and spindle pole associated protein 1 isoform X9

    See identical proteins and their annotated locations for XP_006495545.1

    UniProtKB/Swiss-Prot
    B2RX88, C7SBE3, C7SBE4, Q8CCQ4, Q8VE83, Q9CQD5
  13. XM_036163267.1XP_036019160.1  centrosome and spindle pole associated protein 1 isoform X11

  14. XM_036163260.1XP_036019153.1  centrosome and spindle pole associated protein 1 isoform X6

  15. XM_017319604.2XP_017175093.1  centrosome and spindle pole associated protein 1 isoform X16

  16. XM_036163262.1XP_036019155.1  centrosome and spindle pole associated protein 1 isoform X8

  17. XM_006495483.4XP_006495546.1  centrosome and spindle pole associated protein 1 isoform X10

    See identical proteins and their annotated locations for XP_006495546.1

    UniProtKB/Swiss-Prot
    B2RX88
  18. XM_030252688.2XP_030108548.1  centrosome and spindle pole associated protein 1 isoform X12

    Conserved Domains (1) summary
    pfam13904
    Location:573696
    DUF4207; Domain of unknown function (DUF4207)
  19. XM_017319609.2XP_017175098.1  centrosome and spindle pole associated protein 1 isoform X20

    Conserved Domains (1) summary
    pfam13904
    Location:59182
    DUF4207; Domain of unknown function (DUF4207)
  20. XM_036163264.1XP_036019157.1  centrosome and spindle pole associated protein 1 isoform X8

  21. XM_030252692.2XP_030108552.1  centrosome and spindle pole associated protein 1 isoform X17

  22. XM_036163294.1XP_036019187.1  centrosome and spindle pole associated protein 1 isoform X19

RNA

  1. XR_004941385.1 RNA Sequence

  2. XR_004941384.1 RNA Sequence

  3. XR_004941386.1 RNA Sequence