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GEMIN6 gem nuclear organelle associated protein 6 [ Homo sapiens (human) ]

Gene ID: 79833, updated on 24-Nov-2020

Summary

Official Symbol
GEMIN6provided by HGNC
Official Full Name
gem nuclear organelle associated protein 6provided by HGNC
Primary source
HGNC:HGNC:20044
See related
Ensembl:ENSG00000152147 MIM:607006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in testis (RPKM 12.8), lymph node (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See GEMIN6 in Genome Data Viewer
Location:
2p22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (38778210..38785002)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39005327..39009598)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39D, pseudogene Neighboring gene NPL pseudogene 1 Neighboring gene DExH-box helicase 57 Neighboring gene argininosuccinate synthetase 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 4728

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with gem (nuclear organelle) associated protein 6 (GEMIN6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ23459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
import into nucleus TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
PubMed 
spliceosomal complex assembly IEA
Inferred from Electronic Annotation
more info
 
spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Gemini of coiled bodies IDA
Inferred from Direct Assay
more info
PubMed 
SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMN complex IDA
Inferred from Direct Assay
more info
PubMed 
SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gem-associated protein 6
Names
SIP2
gemin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024775.10NP_079051.9  gem-associated protein 6

    See identical proteins and their annotated locations for NP_079051.9

    Status: VALIDATED

    Source sequence(s)
    AC018693, BC029584, BM471707
    Consensus CDS
    CCDS1799.1
    UniProtKB/Swiss-Prot
    Q8WXD5
    Related
    ENSP00000281950.2, ENST00000281950.8
    Conserved Domains (1) summary
    cl00259
    Location:1167
    Sm_like; Sm and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    38778210..38785002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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