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Gemin6 gem nuclear organelle associated protein 6 [ Mus musculus (house mouse) ]

Gene ID: 67242, updated on 30-Apr-2024

Summary

Official Symbol
Gemin6provided by MGI
Official Full Name
gem nuclear organelle associated protein 6provided by MGI
Primary source
MGI:MGI:1914492
See related
Ensembl:ENSMUSG00000055760 AllianceGenome:MGI:1914492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610019B15Rik; 2810470M17Rik
Summary
Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Gemini of coiled bodies and cytosol. Predicted to be part of SMN complex. Is expressed in brain and spinal cord. Orthologous to human GEMIN6 (gem nuclear organelle associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 16.4), liver E14 (RPKM 9.9) and 19 other tissues See more
Orthologs
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Genomic context

See Gemin6 in Genome Data Viewer
Location:
17 E3; 17 50.63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80514933..80535926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80207504..80228497)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 12189 Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene serine and arginine-rich splicing factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in spliceosomal complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Gemini of coiled bodies ISO
Inferred from Sequence Orthology
more info
 
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SMN complex ISO
Inferred from Sequence Orthology
more info
 
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gem-associated protein 6
Names
gemin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355458.1NP_001342387.1  gem-associated protein 6

    Status: VALIDATED

    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS28989.1
    UniProtKB/Swiss-Prot
    Q3TIW7, Q9CQI0, Q9CX53, Q9CXC5
    Conserved Domains (1) summary
    pfam06372
    Location:1166
    Gemin6; Gemin6 protein
  2. NM_026053.4NP_080329.1  gem-associated protein 6

    See identical proteins and their annotated locations for NP_080329.1

    Status: VALIDATED

    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS28989.1
    UniProtKB/Swiss-Prot
    Q3TIW7, Q9CQI0, Q9CX53, Q9CXC5
    Related
    ENSMUSP00000063554.7, ENSMUST00000069486.13
    Conserved Domains (1) summary
    pfam06372
    Location:1166
    Gemin6; Gemin6 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80514933..80535926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246581.3XP_011244883.1  gem-associated protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011244883.1

    UniProtKB/Swiss-Prot
    Q3TIW7, Q9CQI0, Q9CX53, Q9CXC5
    Conserved Domains (1) summary
    pfam06372
    Location:1166
    Gemin6; Gemin6 protein