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SHCBP1 SHC binding and spindle associated 1 [ Homo sapiens (human) ]

Gene ID: 79801, updated on 6-Sep-2022

Summary

Official Symbol
SHCBP1provided by HGNC
Official Full Name
SHC binding and spindle associated 1provided by HGNC
Primary source
HGNC:HGNC:29547
See related
Ensembl:ENSG00000171241 MIM:611027; AllianceGenome:HGNC:29547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAL
Summary
Predicted to enable SH2 domain binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm; midbody; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 5.2), lymph node (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

See SHCBP1 in Genome Data Viewer
Location:
16q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (46578591..46621379, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (52375421..52418229, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46612503..46655291, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 14 pseudogene Neighboring gene RAB31, member RAS oncogene family pseudogene Neighboring gene RAB43 pseudogene 1 Neighboring gene VPS35 retromer complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SHC SH2-domain binding protein 1 (SHCBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22009, MGC26900

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SHC SH2 domain-binding protein 1
Names
Protein expressed in Activated Lymphocytes

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324318.2NP_001311247.1  SHC SH2 domain-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092368
  2. NM_001324319.2NP_001311248.1  SHC SH2 domain-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092368
  3. NM_024745.5NP_079021.4  SHC SH2 domain-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092368
    Consensus CDS
    CCDS10720.1
    UniProtKB/Swiss-Prot
    Q9H6P6
    Related
    ENSP00000306473.3, ENST00000303383.8
    Conserved Domains (1) summary
    pfam13229
    Location:446547
    Beta_helix; Right handed beta helix region

RNA

  1. NR_136738.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092368

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    46578591..46621379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434653.1XP_047290609.1  SHC SH2 domain-binding protein 1 isoform X1

  2. XM_011523335.4XP_011521637.1  SHC SH2 domain-binding protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    52375421..52418229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)