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Shcbp1 Shc SH2-domain binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 20419, updated on 7-May-2024

Summary

Official Symbol
Shcbp1provided by MGI
Official Full Name
Shc SH2-domain binding protein 1provided by MGI
Primary source
MGI:MGI:1338802
See related
Ensembl:ENSMUSG00000022322 AllianceGenome:MGI:1338802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPAL
Summary
Enables SH2 domain binding activity. Involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in brain ventricular layer; forebrain; forelimb bud; nephrogenic zone; and submandibular gland primordium. Orthologous to human SHCBP1 (SHC binding and spindle associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 16.0), liver E14 (RPKM 13.9) and 10 other tissues See more
Orthologs
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Genomic context

See Shcbp1 in Genome Data Viewer
Location:
8 A1.1; 8 2.09 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4785976..4829549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4735976..4779567, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20622 Neighboring gene high mobility group protein 1 pseudogene Neighboring gene predicted gene, 39124 Neighboring gene STARR-seq mESC enhancer starr_20623 Neighboring gene STARR-positive B cell enhancer ABC_E1100 Neighboring gene protein kinase inhibitor, gamma pseudogene Neighboring gene STARR-seq mESC enhancer starr_20624 Neighboring gene ribosomal protein L22 pseudogene Neighboring gene ribosomal protein L21, pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SHC SH2 domain-binding protein 1
Names
SHC-binding protein
protein expressed in activated lymphocytes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011369.4NP_035499.1  SHC SH2 domain-binding protein 1

    See identical proteins and their annotated locations for NP_035499.1

    Status: VALIDATED

    Source sequence(s)
    AC129942, AC155814
    Consensus CDS
    CCDS22088.1
    UniProtKB/Swiss-Prot
    Q3UED9, Q3UMD9, Q9Z179
    Related
    ENSMUSP00000022945.8, ENSMUST00000022945.9
    Conserved Domains (1) summary
    pfam13229
    Location:413559
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4785976..4829549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)