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IQCA1 IQ motif containing with AAA domain 1 [ Homo sapiens (human) ]

Gene ID: 79781, updated on 11-Jun-2021

Summary

Official Symbol
IQCA1provided by HGNC
Official Full Name
IQ motif containing with AAA domain 1provided by HGNC
Primary source
HGNC:HGNC:26195
See related
Ensembl:ENSG00000132321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IQCA; DRC11; 4930465P12Rik
Summary
The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Biased expression in thyroid (RPKM 10.5), brain (RPKM 3.7) and 10 other tissues See more
Orthologs
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Genomic context

See IQCA1 in Genome Data Viewer
Location:
2q37.2-q37.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (236324147..236507476, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237232794..237416119, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 2 Neighboring gene RNA, U1 small nuclear 31, pseudogene Neighboring gene ankyrin repeat and SOCS box containing 18 Neighboring gene uncharacterized LOC105373945 Neighboring gene ribosomal protein L3 pseudogene 5 Neighboring gene uncharacterized LOC105373991 Neighboring gene atypical chemokine receptor 3 Neighboring gene uncharacterized LOC107986001

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association of lipid-lowering response to statins in combined study populations.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of IQ motif containing with AAA domain 1 (IQCA1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ22527, FLJ33588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein regulatory complex protein 11
Names
IQ and AAA domain-containing protein 1
dynein regulatory complex subunit 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270584.2NP_001257513.1  dynein regulatory complex protein 11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK294105, BC043504, CD688750
    Consensus CDS
    CCDS59441.1
    UniProtKB/Swiss-Prot
    Q86XH1
    Related
    ENSP00000311951.6, ENST00000309507.9
    Conserved Domains (2) summary
    COG0464
    Location:448747
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:530663
    AAA; ATPase family associated with various cellular activities (AAA)
  2. NM_001270585.2NP_001257514.1  dynein regulatory complex protein 11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in an internal exon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK295566, BC043504, BX117697, HY127810
    Consensus CDS
    CCDS74677.1
    UniProtKB/Swiss-Prot
    Q86XH1
    UniProtKB/TrEMBL
    A0A0A0MSY6, B4DIF4
    Related
    ENSP00000407213.3, ENST00000431676.6
    Conserved Domains (2) summary
    COG0464
    Location:497796
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:579712
    AAA; ATPase family associated with various cellular activities (AAA)
  3. NM_024726.5NP_079002.3  dynein regulatory complex protein 11 isoform 1

    See identical proteins and their annotated locations for NP_079002.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC043504, CD688750
    Consensus CDS
    CCDS46549.1
    UniProtKB/Swiss-Prot
    Q86XH1
    Related
    ENSP00000387347.3, ENST00000409907.8
    Conserved Domains (1) summary
    COG0464
    Location:489788
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RNA

  1. NR_073043.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC028699, BC043504
    Related
    ENST00000254653.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    236324147..236507476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004960.1XP_016860449.1  dynein regulatory complex protein 11 isoform X4

    Conserved Domains (1) summary
    COG0464
    Location:455754
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. XM_011511866.1XP_011510168.1  dynein regulatory complex protein 11 isoform X3

    Conserved Domains (1) summary
    COG0464
    Location:456755
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  3. XM_011511865.3XP_011510167.1  dynein regulatory complex protein 11 isoform X2

    Conserved Domains (1) summary
    COG0464
    Location:490789
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  4. XM_011511864.2XP_011510166.1  dynein regulatory complex protein 11 isoform X1

    Conserved Domains (1) summary
    COG0464
    Location:496795
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
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