Iqca IQ motif containing with AAA domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iqcaprovided by MGI
Official Full Name: IQ motif containing with AAA domainprovided by MGI
Primary source: MGI:MGI:1922168
See related: Ensembl:ENSMUSG00000026301 AllianceGenome:MGI:1922168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iqca1; 4930465P12Rik; 4930585L22Rik
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Is expressed in lung. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 3.5), lung adult (RPKM 0.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 D

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (89969854..90081158, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (90042132..90153436, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB288505 (e-PCR)
- UniSTS:207190

D1Mit488 (e-PCR), detects polymorphism
- UniSTS:128855

Homology

Homologs of the Iqca gene: The Iqca gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 393 organisms have orthologs with human gene Iqca
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein regulatory complex protein 11

Names: IQ and AAA domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368722.1 → NP_001355651.1 dynein regulatory complex protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

AC110261, AC124227

Related

ENSMUSP00000148643.2, ENSMUST00000212394.2

Conserved Domains (1) summary

COG0464
Location:578 → 797

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_029122.2 → NP_083398.2 dynein regulatory complex protein 11 isoform 1

Status: VALIDATED

Source sequence(s)

AC110261, AC124227

Consensus CDS

CCDS48317.1

UniProtKB/TrEMBL

E9QMY8

Related

ENSMUSP00000108717.3, ENSMUST00000113094.9

Conserved Domains (2) summary

COG0464
Location:569 → 788

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam00004
Location:571 → 704

AAA; ATPase family associated with various cellular activities (AAA)