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NLRX1 NLR family member X1 [ Homo sapiens (human) ]

Gene ID: 79671, updated on 18-Aug-2020

Summary

Official Symbol
NLRX1provided by HGNC
Official Full Name
NLR family member X1provided by HGNC
Primary source
HGNC:HGNC:29890
See related
Ensembl:ENSG00000160703 MIM:611947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOD5; NOD9; NOD26; DLNB26; CLR11.3
Summary
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in esophagus (RPKM 15.5), skin (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See NLRX1 in Genome Data Viewer
Location:
11q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119168334..119184016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119039036..119054725)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene PDZ domain containing 3 Neighboring gene coiled-coil domain containing 153 Neighboring gene small nucleolar RNA, C/D box 150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NLR family member X1 (NLRX1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21478, MGC21025, MGC131937

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NLR family member X1
Names
NOD-like receptor X1
caterpiller protein 11.3
nucleotide-binding oligomerization domain protein 26
nucleotide-binding oligomerization domain protein 5
nucleotide-binding oligomerization domain protein 9
nucleotide-binding oligomerization domain, leucine rich repeat containing X1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047185.1 RefSeqGene

    Range
    5001..20683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282143.2NP_001269072.1  NLR family member X1 precursor

    See identical proteins and their annotated locations for NP_001269072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
    Source sequence(s)
    AB094095, BX647705, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    Q86UT6
    Related
    ENSP00000386851.1, ENST00000409991.5
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001282144.2NP_001269073.1  NLR family member X1 precursor

    See identical proteins and their annotated locations for NP_001269073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AB094095, BC110890, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    Q86UT6
    Related
    ENSP00000387334.1, ENST00000409109.6
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001282358.2NP_001269287.1  NLR family member X1 precursor

    See identical proteins and their annotated locations for NP_001269287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. All variants encode the same protein.
    Source sequence(s)
    AB094095, AP002956, DA441499
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    Q86UT6
    Related
    ENSP00000386858.5, ENST00000409265.8
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_024618.4NP_078894.2  NLR family member X1 precursor

    See identical proteins and their annotated locations for NP_078894.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
    Source sequence(s)
    AB094095, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    Q86UT6
    Related
    ENSP00000292199.2, ENST00000292199.6
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119168334..119184016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542980.1XP_011541282.1  NLR family member X1 isoform X1

    See identical proteins and their annotated locations for XP_011541282.1

    UniProtKB/Swiss-Prot
    Q86UT6
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005271669.1XP_005271726.1  NLR family member X1 isoform X1

    See identical proteins and their annotated locations for XP_005271726.1

    UniProtKB/Swiss-Prot
    Q86UT6
    Conserved Domains (3) summary
    cd00116
    Location:698885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005271671.1XP_005271728.1  NLR family member X1 isoform X3

    See identical proteins and their annotated locations for XP_005271728.1

    Conserved Domains (3) summary
    cd00116
    Location:520707
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:520548
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:2142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_005271672.1XP_005271729.1  NLR family member X1 isoform X3

    See identical proteins and their annotated locations for XP_005271729.1

    Conserved Domains (3) summary
    cd00116
    Location:520707
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:520548
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:2142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_006718904.1XP_006718967.1  NLR family member X1 isoform X2

    UniProtKB/Swiss-Prot
    Q86UT6
    Related
    ENSP00000433442.1, ENST00000525863.1
    Conserved Domains (3) summary
    cd00116
    Location:698850
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:698726
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21455
    Location:161320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017018294.2XP_016873783.1  NLR family member X1 isoform X4

  7. XM_005271670.1XP_005271727.1  NLR family member X1 isoform X3

    See identical proteins and their annotated locations for XP_005271727.1

    Conserved Domains (3) summary
    cd00116
    Location:520707
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:520548
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:2142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170722.1: Suppressed sequence

    Description
    NM_170722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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