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CALCA calcitonin related polypeptide alpha [ Homo sapiens (human) ]

Gene ID: 796, updated on 2-Aug-2021

Summary

Official Symbol
CALCAprovided by HGNC
Official Full Name
calcitonin related polypeptide alphaprovided by HGNC
Primary source
HGNC:HGNC:1437
See related
Ensembl:ENSG00000110680 MIM:114130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I; CGRP-alpha
Summary
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Expression
Restricted expression toward thyroid (RPKM 13.7) See more
Orthologs
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Genomic context

See CALCA in Genome Data Viewer
Location:
11p15.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (14966668..14972361, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14988214..14993897, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene calcitonin pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 41 pseudogene Neighboring gene calcitonin related polypeptide beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcitonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcitonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcitonin; calcitonin gene-related peptide 1
Names
alpha-type CGRP
calcitonin 1
calcitonin gene-related peptide I
calcitonin/calcitonin-related polypeptide, alpha
katacalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015960.1 RefSeqGene

    Range
    5001..10618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_13

mRNA and Protein(s)

  1. NM_001033952.3NP_001029124.1  calcitonin isoform CT preproprotein

    See identical proteins and their annotated locations for NP_001029124.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
    Source sequence(s)
    AC090835, FO082042
    Consensus CDS
    CCDS7819.1
    UniProtKB/Swiss-Prot
    P01258
    Related
    ENSP00000379657.2, ENST00000396372.2
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. NM_001033953.3NP_001029125.1  calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein

    See identical proteins and their annotated locations for NP_001029125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest coding transcript and encodes the shorter protein, which is cleaved to yield calcitonin gene-related peptide 1 (alpha-CGRP). Alpha-CGRP functions both as an antimicrobial peptide and a vasodilator.
    Source sequence(s)
    AC090835, FO082042
    Consensus CDS
    CCDS31432.1
    UniProtKB/Swiss-Prot
    P06881
    Related
    ENSP00000354286.3, ENST00000361010.7
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  3. NM_001378949.1NP_001365878.1  calcitonin isoform CT preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090835, FO082042
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  4. NM_001378950.1NP_001365879.1  calcitonin isoform alpha-CGRP preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090835, FO082042
    Related
    ENSP00000417833.1, ENST00000486207.5
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  5. NM_001741.3NP_001732.1  calcitonin isoform CT preproprotein

    See identical proteins and their annotated locations for NP_001732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and the coding region compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
    Source sequence(s)
    AC090835, BC069704, BF942024
    Consensus CDS
    CCDS7819.1
    UniProtKB/Swiss-Prot
    P01258
    Related
    ENSP00000331746.4, ENST00000331587.9
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RNA

  1. NR_125898.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090835, BC069684, BX094781, CB048118, M64486
  2. NR_166196.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090835, FO082042

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    14966668..14972361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018283.1XP_016873772.1  calcitonin isoform X1

    UniProtKB/Swiss-Prot
    P01258
    Related
    ENSP00000420618.1, ENST00000469608.5
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. XM_017018284.1XP_016873773.1  calcitonin isoform X1

    UniProtKB/Swiss-Prot
    P01258
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
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