NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|76880478|ref|NP_001029125|]
View 

calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein [Homo sapiens]

Protein Classification

adrenomedullin/calcitonin family protein( domain architecture ID 11989841)

adrenomedullin/calcitonin family protein similar to human calcitonin that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-123 3.22e-59

Calcitonin / CGRP / IAPP family;


:

Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 178.79  E-value: 3.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880478     1 MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPaDPATLSEDEARL----LLAALVQDYVQMKASELEQEQERE--G 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSP-DPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQVREteG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 76880478    75 SRI--IAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRR 123
Cdd:pfam00214  80 SSLthIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-123 3.22e-59

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 178.79  E-value: 3.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880478     1 MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPaDPATLSEDEARL----LLAALVQDYVQMKASELEQEQERE--G 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSP-DPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQVREteG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 76880478    75 SRI--IAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRR 123
Cdd:pfam00214  80 SSLthIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 81-123 8.66e-14

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 60.62  E-value: 8.66e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 76880478     81 KRACDTATCVTHRLAGLLSRSGGvvknnFVPTNVGSKAFGRRR 123
Cdd:smart00113   1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKKR 38
 
Name Accession Description Interval E-value
Calc_CGRP_IAPP pfam00214
Calcitonin / CGRP / IAPP family;
1-123 3.22e-59

Calcitonin / CGRP / IAPP family;


Pssm-ID: 459715 [Multi-domain]  Cd Length: 130  Bit Score: 178.79  E-value: 3.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76880478     1 MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPaDPATLSEDEARL----LLAALVQDYVQMKASELEQEQERE--G 74
Cdd:pfam00214   1 MGFWKFSPFLLLSILLLYQAGSLQAAPFRSALESSP-DPATLSEEESRLkkskLLAALVKDYVQMKAEELEQEQVREteG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 76880478    75 SRI--IAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRR 123
Cdd:pfam00214  80 SSLthIRQKRGCNLATCVTHRLAHFLSRSGNKVKDNFAPTNVGPKGYGRRR 130
CALCITONIN smart00113
calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and ...
 81-123 8.66e-14

calcitonin; This family is formed by calcitonin, the calcitonin gene-related peptide, and amylin. They are short polypeptide hormones.


Pssm-ID: 128423  Cd Length: 38  Bit Score: 60.62  E-value: 8.66e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 76880478     81 KRACDTATCVTHRLAGLLSRSGGvvknnFVPTNVGSKAFGRRR 123
Cdd:smart00113   1 KRCCNLSTCVLGRLADDLNRSHT-----YSPTNVGSGTPGKKR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH