Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study

Genes Immun. 2014 Dec;15(8):578-83. doi: 10.1038/gene.2014.52. Epub 2014 Sep 11.

Abstract

This genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels measured in blood collected at age 6 years (n=673) and at age 14 years (n=1140). Replication of significantly associated genes from previous GWASs was found for both ages. Genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in PDE3B/CYP2R1 (age 6: rs1007392, P=3.9 × 10(-8); age14: rs11023332, P=2.2 × 10(-10)) and on chromosome 4q13 in GC (age 6: rs17467825, P=4.2 × 10(-9); age14: rs1155563; P=3.9 × 10(-9)). In addition, a novel association was observed at age 6 with SNPs on chromosome 7p15 near NPY (age 6: rs156299, P=1.3 × 10(-6)) that could be of functional interest in highlighting alternative pathways for vitamin D metabolism in this age group and merits further analysis in other cohort studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Cholestanetriol 26-Monooxygenase / genetics*
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 7 / genetics
  • Cohort Studies
  • Cyclic Nucleotide Phosphodiesterases, Type 3 / genetics*
  • Cytochrome P450 Family 2
  • DNA Replication / genetics
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • Genome, Human / genetics*
  • Genotype
  • Humans
  • Male
  • Neuropeptide Y / genetics
  • Polymorphism, Single Nucleotide*
  • Pregnancy
  • Signal Transduction / genetics
  • Vitamin D / blood*
  • Western Australia

Substances

  • Neuropeptide Y
  • Vitamin D
  • Cytochrome P450 Family 2
  • CYP2R1 protein, human
  • Cholestanetriol 26-Monooxygenase
  • Cyclic Nucleotide Phosphodiesterases, Type 3
  • PDE3B protein, human