U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

klhl14 kelch-like family member 14 [ Danio rerio (zebrafish) ]

Gene ID: 794722, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
klhl14provided by ZNC
Official Full Name
kelch-like family member 14provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-223
See related
Ensembl:ENSDARG00000045275 AllianceGenome:ZFIN:ZDB-GENE-091204-223
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkeyp-7a3.2
Summary
Orthologous to human KLHL14 (kelch like family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See klhl14 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (35880648..35907272)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (35991683..36019172)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene dystrobrevin, alpha Neighboring gene coiled-coil domain containing 178 Neighboring gene ATP-binding cassette, sub-family D (ALD), member 4 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b Neighboring gene guanine nucleotide-binding protein G(s) subunit alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy. Gupta VA, et al. Am J Hum Genet, 2013 Dec 5. PMID 24268659, Free PMC Article
  2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch-like protein 14
Names
kelch-like 14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    35880648..35907272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162873.5 → XP_005162930.1  kelch-like protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B9Z2, E7FH32, E9QC80
    Related
    ENSDARP00000121232.1, ENSDART00000143015.3
    Conserved Domains (6) summary
    smart00612
    Location:404 → 450
    Kelch; Kelch domain
    smart00875
    Location:168 → 256
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:30 → 579
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:342 → 389
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:23 → 156
    BTB; BTB/POZ domain
    pfam01344
    Location:439 → 484
    Kelch_1; Kelch motif

  2. XM_001334693.8 → XP_001334729.4  kelch-like protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8M1PS01
    Conserved Domains (6) summary
    smart00612
    Location:413 → 459
    Kelch; Kelch domain
    smart00875
    Location:177 → 265
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:39 → 588
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:351 → 398
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:32 → 165
    BTB; BTB/POZ domain
    pfam01344
    Location:448 → 493
    Kelch_1; Kelch motif
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools