Format

Send to:

Choose Destination

KLHL14 kelch like family member 14 [ Homo sapiens (human) ]

Gene ID: 57565, updated on 23-Nov-2021

Summary

Official Symbol
KLHL14provided by HGNC
Official Full Name
kelch like family member 14provided by HGNC
Primary source
HGNC:HGNC:29266
See related
Ensembl:ENSG00000197705 MIM:613772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]
Expression
Biased expression in thyroid (RPKM 4.4), spleen (RPKM 2.8) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KLHL14 in Genome Data Viewer
Location:
18q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (32672673..32773023, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (30252636..30352986, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 7 Neighboring gene WBP11 pseudogene 1 Neighboring gene uncharacterized LOC112268208 Neighboring gene uncharacterized LOC105372055 Neighboring gene ribosomal protein S27 pseudogene 28 Neighboring gene uncharacterized LOC105372058

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in aggresome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 14
Names
kelch-like 14
printor
protein interactor of Torsin-1A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020805.3NP_065856.1  kelch-like protein 14

    See identical proteins and their annotated locations for NP_065856.1

    Status: REVIEWED

    Source sequence(s)
    AB037805, AC012123
    Consensus CDS
    CCDS32813.1
    UniProtKB/Swiss-Prot
    Q9P2G3
    Related
    ENSP00000352314.4, ENST00000359358.9
    Conserved Domains (4) summary
    PHA03098
    Location:138600
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:363410
    Kelch; KELCH repeat [structural motif]
    cd18243
    Location:1188
    BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
    cd18453
    Location:181282
    BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    32672673..32773023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526109.2XP_011524411.2  kelch-like protein 14 isoform X1

Support Center