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ZNF343 zinc finger protein 343 [ Homo sapiens (human) ]

Gene ID: 79175, updated on 13-Feb-2019

Summary

Official Symbol
ZNF343provided by HGNC
Official Full Name
zinc finger protein 343provided by HGNC
Primary source
HGNC:HGNC:16017
See related
Ensembl:ENSG00000088876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ734P14.5
Expression
Ubiquitous expression in endometrium (RPKM 3.1), ovary (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF343 in Genome Data Viewer
Location:
20p13
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (2481817..2524522, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2462463..2489778, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transglutaminase 6 Neighboring gene small nucleolar RNA, C/D box 119 Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 Neighboring gene uncharacterized LOC105372504 Neighboring gene transmembrane channel like 2 Neighboring gene uncharacterized LOC105372505

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39592, MGC10715, MGC20504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282495.1NP_001269424.1  zinc finger protein 343 isoform 1

    See identical proteins and their annotated locations for NP_001269424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 7 encode the same isoform (1).
    Source sequence(s)
    AL049712, BC065009, BQ212757
    Consensus CDS
    CCDS13028.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62106
    KRAB; krueppel associated box
    COG5048
    Location:266593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:297319
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:396420
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001282496.1NP_001269425.1  zinc finger protein 343 isoform 1

    See identical proteins and their annotated locations for NP_001269425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 7 encode the same isoform (1).
    Source sequence(s)
    AK096911, BC011862, BQ212757, CD702168, DB061474
    Consensus CDS
    CCDS13028.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62106
    KRAB; krueppel associated box
    COG5048
    Location:266593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:297319
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:396420
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001282497.1NP_001269426.1  zinc finger protein 343 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1. Both variants 4 and 8 encode the same isoform (2).
    Source sequence(s)
    BC065009, BQ212757, DA034001, DB061474, DR002765
    Consensus CDS
    CCDS74693.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    UniProtKB/TrEMBL
    A0A087WZQ2
    Conserved Domains (6) summary
    smart00349
    Location:62102
    KRAB; krueppel associated box
    COG5048
    Location:307634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:396416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618640
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:437461
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001282498.1NP_001269427.1  zinc finger protein 343 isoform 3

    See identical proteins and their annotated locations for NP_001269427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    BC065009, BQ212757, DA585339, DB061474
    Consensus CDS
    CCDS74692.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Related
    ENSP00000483851.1, ENST00000617391.4
    Conserved Domains (4) summary
    COG5048
    Location:176503
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:265285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:207229
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:306330
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001282499.1NP_001269428.1  zinc finger protein 343 isoform 4

    See identical proteins and their annotated locations for NP_001269428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC002897, DB061474
    Consensus CDS
    CCDS74694.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Related
    ENSP00000370652.1, ENST00000381253.5
    Conserved Domains (1) summary
    pfam01352
    Location:61102
    KRAB; KRAB box
  6. NM_001321800.1NP_001308729.1  zinc finger protein 343 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1-3 and 7 encode the same isoform (1).
    Source sequence(s)
    AL049650, BC011862, DB217060
    Consensus CDS
    CCDS13028.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62106
    KRAB; krueppel associated box
    COG5048
    Location:266593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:297319
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:396420
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001321801.1NP_001308730.1  zinc finger protein 343 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Both variants 4 and 8 encode the same isoform (2).
    Source sequence(s)
    AL049650, BC011862, DB217060
    Consensus CDS
    CCDS74693.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    UniProtKB/TrEMBL
    A0A087WZQ2
    Related
    ENSP00000482819.1, ENST00000612935.4
    Conserved Domains (6) summary
    smart00349
    Location:62102
    KRAB; krueppel associated box
    COG5048
    Location:307634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:396416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618640
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:437461
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001321802.1NP_001308731.1  zinc finger protein 343 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL049650, AL133339, BC011862, DB061474
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62102
    KRAB; krueppel associated box
    COG5048
    Location:306633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:617639
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:436460
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001321803.1NP_001308732.1  zinc finger protein 343 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL049650, BC011862, DB217060
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62102
    KRAB; krueppel associated box
    COG5048
    Location:306633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:617639
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:436460
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001321805.1NP_001308734.1  zinc finger protein 343 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL049650, AL133339, BC011862, DB061474
    UniProtKB/Swiss-Prot
    Q6P1L6
    Conserved Domains (6) summary
    smart00349
    Location:62106
    KRAB; krueppel associated box
    COG5048
    Location:265592
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:296318
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:395419
    zf-H2C2_2; Zinc-finger double domain
  11. NM_024325.5NP_077301.4  zinc finger protein 343 isoform 1

    See identical proteins and their annotated locations for NP_077301.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1-3 and 7 encode the same isoform (1).
    Source sequence(s)
    AK096911, BC011862, BQ212757, DB061474, DR002765
    Consensus CDS
    CCDS13028.1
    UniProtKB/Swiss-Prot
    Q6P1L6
    Related
    ENSP00000278772.4, ENST00000278772.8
    Conserved Domains (6) summary
    smart00349
    Location:62106
    KRAB; krueppel associated box
    COG5048
    Location:266593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:297319
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:62101
    KRAB; KRAB box
    pfam13465
    Location:396420
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    2481817..2524522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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