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LILRA6 leukocyte immunoglobulin like receptor A6 [ Homo sapiens (human) ]

Gene ID: 79168, updated on 5-Jan-2022

Summary

Official Symbol
LILRA6provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A6provided by HGNC
Primary source
HGNC:HGNC:15495
See related
Ensembl:ENSG00000244482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT5; ILT8; CD85b; ILT-8; LILRB3; LILRB6
Summary
Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in appendix (RPKM 13.1), spleen (RPKM 5.9) and 7 other tissues See more
Orthologs
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Genomic context

See LILRA6 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54236590..54242790, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571054.1 (211366..293785, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_004166865.1 (210957..217157, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene LSM14A, SCD6 homolog A (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC107985279 Neighboring gene leukocyte immunoglobulin like receptor B5 Neighboring gene RNA, U6 small nuclear 1307, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 6
Names
immunoglobulin-like transcript 5
immunoglobulin-like transcript 8
leucocyte Ig-like receptor A6
leukocyte Ig-like receptor
leukocyte immunoglobulin like receptor B3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360167.1NP_001347096.1  leukocyte immunoglobulin-like receptor subfamily A member 6 precursor

    Status: VALIDATED

    Source sequence(s)
    KC918866
    Conserved Domains (2) summary
    cd05751
    Location:27118
    Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains
    cl11960
    Location:123217
    Ig; Immunoglobulin domain
  2. NM_024318.4NP_077294.3  leukocyte immunoglobulin-like receptor subfamily A member 6 precursor

    See identical proteins and their annotated locations for NP_077294.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AC245052, AF344432, BC041708
    Consensus CDS
    CCDS42610.1
    UniProtKB/TrEMBL
    U5XH19
    Related
    ENSP00000379651.2, ENST00000396365.6
    Conserved Domains (3) summary
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:237296
    IG_like; Immunoglobulin like
    cl11960
    Location:123217
    Ig; Immunoglobulin domain

RNA

  1. NR_104098.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and includes additional 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC245052
    Related
    ENST00000430421.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54236590..54242790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    212163..217575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547130.2XP_011545432.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X2

    Conserved Domains (3) summary
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:334396
    IG_like; Immunoglobulin like
    cl11960
    Location:123217
    Ig; Immunoglobulin domain

RNA

  1. XR_001756516.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    211579..217752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p13 ALT_REF_LOCI_8

    Range
    213633..217778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    213919..217758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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