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DHX58 DExH-box helicase 58 [ Homo sapiens (human) ]

Gene ID: 79132, updated on 7-Dec-2018

Summary

Official Symbol
DHX58provided by HGNC
Official Full Name
DExH-box helicase 58provided by HGNC
Primary source
HGNC:HGNC:29517
See related
Ensembl:ENSG00000108771 MIM:608588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGP2; RLR-3; D11LGP2; D11lgp2e
Expression
Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See DHX58 in Genome Data Viewer
Location:
17q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42101404..42112733, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40253422..40264751, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113 Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MDA-5 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of RIG-I signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DHX58
Names
DEXH (Asp-Glu-X-His) box polypeptide 58
RIG-I-like receptor 3
RIG-I-like receptor LGP2
RLR
RNA helicase LGP2
ortholog of mouse D11lgp2
probable ATP-dependent helicase LGP2
protein D11Lgp2 homolog
NP_077024.2
XP_016880548.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024119.3NP_077024.2  probable ATP-dependent RNA helicase DHX58

    See identical proteins and their annotated locations for NP_077024.2

    Status: VALIDATED

    Source sequence(s)
    AK021416, BC014949
    Consensus CDS
    CCDS11416.1
    UniProtKB/Swiss-Prot
    Q96C10
    UniProtKB/TrEMBL
    A0A024R1Y5
    Related
    ENSP00000251642.3, ENST00000251642.7
    Conserved Domains (5) summary
    COG1111
    Location:2542
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:18170
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15806
    Location:552664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227345
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:350472
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    42101404..42112733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025059.1XP_016880548.1  probable ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/Swiss-Prot
    Q96C10
    UniProtKB/TrEMBL
    A0A024R1Y5
    Conserved Domains (5) summary
    COG1111
    Location:2542
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:18170
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15806
    Location:552664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227345
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:350472
    Helicase_C; Helicase conserved C-terminal domain

RNA

  1. XR_002958067.1 RNA Sequence

  2. XR_001752624.1 RNA Sequence

  3. XR_001752623.1 RNA Sequence

  4. XR_934548.1 RNA Sequence

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