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DHX58 DExH-box helicase 58 [ Homo sapiens (human) ]

Gene ID: 79132, updated on 31-Jan-2024

Summary

Official Symbol
DHX58provided by HGNC
Official Full Name
DExH-box helicase 58provided by HGNC
Primary source
HGNC:HGNC:29517
See related
Ensembl:ENSG00000108771 MIM:608588; AllianceGenome:HGNC:29517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGP2; RLR-3; D11LGP2; D11lgp2e
Summary
Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See DHX58 in Genome Data Viewer
Location:
17q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42101411..42112714, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42957915..42969232, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40253429..40264732, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40180775-40181563 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40203397-40203898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40214064-40214654 Neighboring gene Sharpr-MPRA regulatory region 8946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8513 Neighboring gene Sharpr-MPRA regulatory region 13373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40220039-40220539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40223445-40224418 Neighboring gene Sharpr-MPRA regulatory region 2167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40256421-40257354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40257355-40258286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40259930-40260442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40267799-40268334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40275137-40275674 Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MDA-5 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of RIG-I signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX58
Names
ATP-dependent helicase LGP2
DEXH (Asp-Glu-X-His) box polypeptide 58
RIG-I-like receptor 3
RIG-I-like receptor LGP2
RLR
RNA helicase LGP2
ortholog of mouse D11lgp2
probable ATP-dependent RNA helicase DHX58
probable ATP-dependent helicase LGP2
protein D11Lgp2 homolog
NP_077024.2
XP_047292680.1
XP_047292681.1
XP_047292682.1
XP_047292683.1
XP_054173139.1
XP_054173140.1
XP_054173141.1
XP_054173142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024119.3NP_077024.2  ATP-dependent RNA helicase DHX58

    See identical proteins and their annotated locations for NP_077024.2

    Status: VALIDATED

    Source sequence(s)
    AK021416, BC014949
    Consensus CDS
    CCDS11416.1
    UniProtKB/Swiss-Prot
    Q96C10, Q9HAM6
    UniProtKB/TrEMBL
    A0AA51U9C6, B4DV26
    Related
    ENSP00000251642.3, ENST00000251642.8
    Conserved Domains (4) summary
    cd15806
    Location:552664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227345
    MDA5_ID; Insert domain of MDA5
    cd18802
    Location:349483
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cd18075
    Location:1200
    DEXHc_RLR-3; DEXH-box helicase domain of RLR-3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42101411..42112714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436724.1XP_047292680.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/Swiss-Prot
    Q96C10, Q9HAM6
    UniProtKB/TrEMBL
    A0AA51U9C6, B4DV26
  2. XM_047436725.1XP_047292681.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/Swiss-Prot
    Q96C10, Q9HAM6
    UniProtKB/TrEMBL
    A0AA51U9C6, B4DV26
  3. XM_047436726.1XP_047292682.1  ATP-dependent RNA helicase DHX58 isoform X2

    UniProtKB/TrEMBL
    B3KUP5, E9PHD3
  4. XM_047436727.1XP_047292683.1  ATP-dependent RNA helicase DHX58 isoform X3

    UniProtKB/TrEMBL
    C9JG98
    Related
    ENSP00000416389.1, ENST00000413196.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42957915..42969232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317164.1XP_054173139.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/Swiss-Prot
    Q96C10, Q9HAM6
    UniProtKB/TrEMBL
    A0AA51U9C6, B4DV26
  2. XM_054317165.1XP_054173140.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/Swiss-Prot
    Q96C10, Q9HAM6
    UniProtKB/TrEMBL
    A0AA51U9C6, B4DV26
  3. XM_054317166.1XP_054173141.1  ATP-dependent RNA helicase DHX58 isoform X2

    UniProtKB/TrEMBL
    B3KUP5, E9PHD3
  4. XM_054317167.1XP_054173142.1  ATP-dependent RNA helicase DHX58 isoform X3

    UniProtKB/TrEMBL
    C9JG98