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Dhx58 DExH-box helicase 58 [ Mus musculus (house mouse) ]

Gene ID: 80861, updated on 12-May-2024

Summary

Official Symbol
Dhx58provided by MGI
Official Full Name
DExH-box helicase 58provided by MGI
Primary source
MGI:MGI:1931560
See related
Ensembl:ENSMUSG00000017830 AllianceGenome:MGI:1931560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik
Summary
Enables double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 14.6), testis adult (RPKM 12.3) and 24 other tissues See more
Orthologs
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Genomic context

See Dhx58 in Genome Data Viewer
Location:
11 D; 11 63.52 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100585710..100595165, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100694884..100704271, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene STARR-positive B cell enhancer ABC_E7063 Neighboring gene STARR-positive B cell enhancer ABC_E9843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene K(lysine) acetyltransferase 2A Neighboring gene heat shock protein, alpha-crystallin-related, B9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX58
Names
ATP-dependent helicase LGP2
DEXH (Asp-Glu-X-His) box polypeptide 58
RIG-I-like receptor 3
RIG-I-like receptor Lgp2
RLR
RNA helicase LGP2
probable ATP-dependent RNA helicase DHX58
probable ATP-dependent helicase LGP2
protein D11Lgp2
NP_084426.2
XP_036012999.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030150.2NP_084426.2  ATP-dependent RNA helicase DHX58

    See identical proteins and their annotated locations for NP_084426.2

    Status: VALIDATED

    Source sequence(s)
    AF316999, BP766331, BY727457
    Consensus CDS
    CCDS25431.1
    UniProtKB/Swiss-Prot
    A2A5E9, Q99J87, Q9D1X4
    UniProtKB/TrEMBL
    Q3U606
    Related
    ENSMUSP00000017974.7, ENSMUST00000017974.13
    Conserved Domains (5) summary
    COG1111
    Location:2550
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd15806
    Location:552664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227345
    MDA5_ID; Insert domain of MDA5
    pfam00271
    Location:350475
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:1170
    ResIII; Type III restriction enzyme, res subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100585710..100595165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157106.1XP_036012999.1  ATP-dependent RNA helicase DHX58 isoform X1

    UniProtKB/TrEMBL
    Q3U606
    Conserved Domains (4) summary
    COG1111
    Location:53481
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd15806
    Location:483595
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd18802
    Location:280414
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cl28899
    Location:1131
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily