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ZNF426 zinc finger protein 426 [ Homo sapiens (human) ]

Gene ID: 79088, updated on 12-Oct-2019

Summary

Official Symbol
ZNF426provided by HGNC
Official Full Name
zinc finger protein 426provided by HGNC
Primary source
HGNC:HGNC:20725
See related
Ensembl:ENSG00000130818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K-RBP
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in esophagus (RPKM 5.6), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF426 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9523223..9538865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9638667..9649638, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K member 8 Gag polyprotein-like Neighboring gene zinc finger protein 560 Neighboring gene uncharacterized LOC105372268 Neighboring gene actin beta pseudogene Neighboring gene ZNF426 divergent transcript Neighboring gene zinc finger protein 121 Neighboring gene uncharacterized LOC105376914

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2663

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 426
Names
CTC-543D15.7
KSHV RTA binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300883.3NP_001287812.1  zinc finger protein 426 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB209837, AC008567, BP245135
    Consensus CDS
    CCDS74279.1
    UniProtKB/TrEMBL
    K7ER43, Q59EH4
    Related
    ENSP00000468100.1, ENST00000593003.5
    Conserved Domains (6) summary
    smart00349
    Location:460
    KRAB; krueppel associated box
    COG5048
    Location:296448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:186208
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001318055.2NP_001304984.1  zinc finger protein 426 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008567, BC001791, BP245135
    UniProtKB/Swiss-Prot
    Q9BUY5
    Conserved Domains (4) summary
    COG5048
    Location:223375
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:339359
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:113135
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:351376
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001318056.2NP_001304985.1  zinc finger protein 426 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008567, BC001791, BE315219, BP245135
    Consensus CDS
    CCDS82285.1
    UniProtKB/Swiss-Prot
    Q9BUY5
    UniProtKB/TrEMBL
    K7EME3
    Conserved Domains (1) summary
    smart00349
    Location:4298
    KRAB; krueppel associated box
  4. NM_024106.3NP_077011.1  zinc finger protein 426 isoform 1

    See identical proteins and their annotated locations for NP_077011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008567, BC001791, BP245135
    Consensus CDS
    CCDS12215.1
    UniProtKB/Swiss-Prot
    Q9BUY5
    UniProtKB/TrEMBL
    A0A024R7D7
    Related
    ENSP00000253115.1, ENST00000253115.7
    Conserved Domains (5) summary
    smart00349
    Location:4298
    KRAB; krueppel associated box
    COG5048
    Location:334486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:294319
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9523223..9538865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027293.2XP_016882782.1  zinc finger protein 426 isoform X2

    UniProtKB/TrEMBL
    K7ER43
    Conserved Domains (6) summary
    smart00349
    Location:460
    KRAB; krueppel associated box
    COG5048
    Location:296448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:186208
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024451704.1XP_024307472.1  zinc finger protein 426 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:92244
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:230308
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027294.1XP_016882783.1  zinc finger protein 426 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:92244
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:230308
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  4. XM_024451703.1XP_024307471.1  zinc finger protein 426 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:92244
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:230308
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  5. XM_024451705.1XP_024307473.1  zinc finger protein 426 isoform X4

    Related
    ENSP00000466469.1, ENST00000589289.1
    Conserved Domains (1) summary
    smart00349
    Location:4298
    KRAB; krueppel associated box
  6. XM_024451702.1XP_024307470.1  zinc finger protein 426 isoform X1

    Related
    ENSP00000439017.1, ENST00000535489.5
    Conserved Domains (5) summary
    smart00349
    Location:4298
    KRAB; krueppel associated box
    COG5048
    Location:334486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:294319
    zf-H2C2_2; Zinc-finger double domain
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