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DAP3 death associated protein 3 [ Homo sapiens (human) ]

Gene ID: 7818, updated on 3-Mar-2019

Summary

Official Symbol
DAP3provided by HGNC
Official Full Name
death associated protein 3provided by HGNC
Primary source
HGNC:HGNC:2673
See related
Ensembl:ENSG00000132676 MIM:602074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP-3; S29mt; MRPS29; MRP-S29; bMRP-10
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in lymph node (RPKM 26.0), appendix (RPKM 24.7) and 25 other tissues See more
Orthologs

Genomic context

See DAP3 in Genome Data Viewer
Location:
1q22
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155687902..155739010)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155657693..155708801)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like pseudogene Neighboring gene YY1 associated protein 1 Neighboring gene small Cajal body-specific RNA 26A Neighboring gene uncharacterized LOC100505728 Neighboring gene misato family member 2, pseudogene Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of death associated protein 3 (DAP3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TRAIL signaling pathway, organism-specific biosystem
    TRAIL signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12817, MGC126058, MGC126059, DKFZp686G12159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
28S ribosomal protein S29, mitochondrial
Names
ionizing radiation resistance conferring protein
mitochondrial 28S ribosomal protein S29
mitochondrial small ribosomal subunit protein mS29

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199849.1NP_001186778.1  28S ribosomal protein S29, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001186778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK225869, AK302281, AL162734, BC107487, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    P51398
    Conserved Domains (1) summary
    pfam10236
    Location:99393
    DAP3; Mitochondrial ribosomal death-associated protein 3
  2. NM_001199850.1NP_001186779.1  28S ribosomal protein S29, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001186779.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK298201, AK302281, AL162734, BQ183744
    Consensus CDS
    CCDS55646.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000412605.2, ENST00000421487.6
    Conserved Domains (1) summary
    pfam10236
    Location:65359
    DAP3; Mitochondrial ribosomal death-associated protein 3
  3. NM_001199851.1NP_001186780.1  28S ribosomal protein S29, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001186780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK298201, AK302281, AL162734, BQ183744
    Consensus CDS
    CCDS55647.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000445003.1, ENST00000535183.5
    Conserved Domains (1) summary
    pfam10236
    Location:58352
    DAP3; Mitochondrial ribosomal death-associated protein 3
  4. NM_004632.4NP_004623.1  28S ribosomal protein S29, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_004623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (1). Variants 1, 2 and 3 encode the same isoform 1.
    Source sequence(s)
    AL162734, BC107487, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000357320.5, ENST00000368336.9
    Conserved Domains (1) summary
    pfam10236
    Location:99393
    DAP3; Mitochondrial ribosomal death-associated protein 3
  5. NM_033657.2NP_387506.1  28S ribosomal protein S29, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_387506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an additional segment in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162734, BC107488, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000341692.3, ENST00000343043.7
    Conserved Domains (1) summary
    pfam10236
    Location:99393
    DAP3; Mitochondrial ribosomal death-associated protein 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    155687902..155739010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449697.1XP_024305465.1  28S ribosomal protein S29, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam10236
    Location:99393
    DAP3; Mitochondrial ribosomal death-associated protein 3
  2. XM_024449698.1XP_024305466.1  28S ribosomal protein S29, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam10236
    Location:99366
    DAP3; Mitochondrial ribosomal death-associated protein 3
  3. XM_017002291.1XP_016857780.1  28S ribosomal protein S29, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    P51398
    Conserved Domains (1) summary
    pfam10236
    Location:65359
    DAP3; Mitochondrial ribosomal death-associated protein 3
  4. XM_017002294.1XP_016857783.1  28S ribosomal protein S29, mitochondrial isoform X5

  5. XM_017002292.1XP_016857781.1  28S ribosomal protein S29, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000476592.1, ENST00000471642.6
    Conserved Domains (1) summary
    pfam10236
    Location:58352
    DAP3; Mitochondrial ribosomal death-associated protein 3
  6. XM_017002295.1XP_016857784.1  28S ribosomal protein S29, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:58325
    DAP3; Mitochondrial ribosomal death-associated protein 3
  7. XM_024449700.1XP_024305468.1  28S ribosomal protein S29, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:58325
    DAP3; Mitochondrial ribosomal death-associated protein 3
  8. XM_017002289.1XP_016857778.1  28S ribosomal protein S29, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam10236
    Location:99366
    DAP3; Mitochondrial ribosomal death-associated protein 3
  9. XM_005245480.2XP_005245537.1  28S ribosomal protein S29, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_005245537.1

    UniProtKB/Swiss-Prot
    P51398
    Conserved Domains (1) summary
    pfam10236
    Location:65359
    DAP3; Mitochondrial ribosomal death-associated protein 3
  10. XM_005245481.2XP_005245538.1  28S ribosomal protein S29, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_005245538.1

    UniProtKB/Swiss-Prot
    P51398
    Conserved Domains (1) summary
    pfam10236
    Location:58352
    DAP3; Mitochondrial ribosomal death-associated protein 3
  11. XM_017002290.1XP_016857779.1  28S ribosomal protein S29, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam10236
    Location:99366
    DAP3; Mitochondrial ribosomal death-associated protein 3
  12. XM_017002293.1XP_016857782.1  28S ribosomal protein S29, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    P51398
    Conserved Domains (1) summary
    pfam10236
    Location:58352
    DAP3; Mitochondrial ribosomal death-associated protein 3
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