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EVI5 ecotropic viral integration site 5 [ Homo sapiens (human) ]

Gene ID: 7813, updated on 24-Nov-2020

Summary

Official Symbol
EVI5provided by HGNC
Official Full Name
ecotropic viral integration site 5provided by HGNC
Primary source
HGNC:HGNC:3501
See related
Ensembl:ENSG00000067208 MIM:602942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NB4S; EVI-5
Expression
Ubiquitous expression in testis (RPKM 3.8), placenta (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See EVI5 in Genome Data Viewer
Location:
1p22.1
Exon count:
30
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (92508696..92792413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (92974253..93257961, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glomulin, FKBP associated protein Neighboring gene RNA, 7SL, cytoplasmic 824, pseudogene Neighboring gene growth factor independent 1 transcriptional repressor Neighboring gene succinate dehydrogenase assembly factor 3, mitochondrial pseudogene Neighboring gene high mobility group box 3 pseudogene 9 Neighboring gene zinc finger AN1-type containing 1 pseudogene Neighboring gene RNA, U4 small nuclear 59, pseudogene Neighboring gene cyclin J pseudogene 2 Neighboring gene H3 histone pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene small nucleolar RNA, H/ACA box 66 Neighboring gene divergent protein kinase domain 1A Neighboring gene ribosomal protein L5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ecotropic viral integration site 5 protein homolog
Names
dJ846D11.1 (ecotropic viral integration site 5)
neuroblastoma stage 4S gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308248.2NP_001295177.1  ecotropic viral integration site 5 protein homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC104332, AC104456, AL133332, AL354890
    Consensus CDS
    CCDS76179.1
    UniProtKB/Swiss-Prot
    O60447
    UniProtKB/TrEMBL
    Q59FE7
    Related
    ENSP00000440826.2, ENST00000540033.2
    Conserved Domains (3) summary
    smart00164
    Location:160368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:511606
    CBP4; CBP4
    cl11555
    Location:464504
    DUF1129; Protein of unknown function (DUF1129)
  2. NM_001350197.2NP_001337126.1  ecotropic viral integration site 5 protein homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA725529, AB209513, AB449875, AC104332, AC104456, BM835541, BP282704, BX369930, BX378682, CN334472
    Conserved Domains (2) summary
    smart00164
    Location:116324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl25732
    Location:349693
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001350198.2NP_001337127.1  ecotropic viral integration site 5 protein homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA725529, AB209513, AB449875, AC104332, AC104456, BM835541, BP282704, BX378682, CN334472
    Conserved Domains (2) summary
    smart00164
    Location:116324
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl25732
    Location:349693
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001377210.1NP_001364139.1  ecotropic viral integration site 5 protein homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104332, AC104456, AL354890
  5. NM_001377211.1NP_001364140.1  ecotropic viral integration site 5 protein homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104332, AC104456, AL354890
  6. NM_001377212.1NP_001364141.1  ecotropic viral integration site 5 protein homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC104332, AC104456, AL354890
  7. NM_001377213.1NP_001364142.1  ecotropic viral integration site 5 protein homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC104332, AC104456, AL354890
  8. NM_005665.6NP_005656.4  ecotropic viral integration site 5 protein homolog isoform 2

    See identical proteins and their annotated locations for NP_005656.4

    Status: VALIDATED

    Source sequence(s)
    AA725529, AB209513, AC104332, AC104456, AF008915, AL133332, CN334472
    Consensus CDS
    CCDS30774.1
    UniProtKB/Swiss-Prot
    O60447
    UniProtKB/TrEMBL
    Q59FE7
    Related
    ENSP00000359356.1, ENST00000370331.5
    Conserved Domains (3) summary
    smart00164
    Location:160368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:500595
    CBP4; CBP4
    cl11555
    Location:453493
    DUF1129; Protein of unknown function (DUF1129)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    92508696..92792413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002272.1XP_016857761.1  ecotropic viral integration site 5 protein homolog isoform X4

  2. XM_017002271.2XP_016857760.1  ecotropic viral integration site 5 protein homolog isoform X3

  3. XM_017002277.1XP_016857766.1  ecotropic viral integration site 5 protein homolog isoform X8

  4. XM_017002283.1XP_016857772.1  ecotropic viral integration site 5 protein homolog isoform X15

  5. XM_017002278.1XP_016857767.1  ecotropic viral integration site 5 protein homolog isoform X9

  6. XM_017002269.1XP_016857758.1  ecotropic viral integration site 5 protein homolog isoform X1

  7. XM_017002282.1XP_016857771.1  ecotropic viral integration site 5 protein homolog isoform X14

  8. XM_017002273.2XP_016857762.1  ecotropic viral integration site 5 protein homolog isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:143351
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:543638
    CBP4; CBP4
    cl11555
    Location:496536
    DUF1129; Protein of unknown function (DUF1129)
  9. XM_017002286.2XP_016857775.1  ecotropic viral integration site 5 protein homolog isoform X17

  10. XM_017002287.2XP_016857776.1  ecotropic viral integration site 5 protein homolog isoform X17

  11. XM_017002276.2XP_016857765.1  ecotropic viral integration site 5 protein homolog isoform X7

  12. XM_017002270.2XP_016857759.1  ecotropic viral integration site 5 protein homolog isoform X2

    Conserved Domains (3) summary
    smart00164
    Location:184392
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:584679
    CBP4; CBP4
    cl11555
    Location:537577
    DUF1129; Protein of unknown function (DUF1129)
  13. XM_017002274.1XP_016857763.1  ecotropic viral integration site 5 protein homolog isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:143351
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:543638
    CBP4; CBP4
    cl11555
    Location:496536
    DUF1129; Protein of unknown function (DUF1129)
  14. XM_017002275.1XP_016857764.1  ecotropic viral integration site 5 protein homolog isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:143351
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam07960
    Location:543638
    CBP4; CBP4
    cl11555
    Location:496536
    DUF1129; Protein of unknown function (DUF1129)
  15. XM_017002279.1XP_016857768.1  ecotropic viral integration site 5 protein homolog isoform X10

  16. XM_024449690.1XP_024305458.1  ecotropic viral integration site 5 protein homolog isoform X13

    Conserved Domains (2) summary
    smart00164
    Location:71279
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl25732
    Location:304648
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_017002288.1XP_016857777.1  ecotropic viral integration site 5 protein homolog isoform X17

  18. XM_024449686.1XP_024305454.1  ecotropic viral integration site 5 protein homolog isoform X6

    Conserved Domains (2) summary
    smart00164
    Location:160368
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl25732
    Location:393737
    SMC_N; RecF/RecN/SMC N terminal domain
  19. XM_024449689.1XP_024305457.1  ecotropic viral integration site 5 protein homolog isoform X11

    Conserved Domains (2) summary
    smart00164
    Location:187395
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl25732
    Location:433745
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_001737401.1 RNA Sequence

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