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LAPTM5 lysosomal protein transmembrane 5 [ Homo sapiens (human) ]

Gene ID: 7805, updated on 7-Jun-2020

Summary

Official Symbol
LAPTM5provided by HGNC
Official Full Name
lysosomal protein transmembrane 5provided by HGNC
Primary source
HGNC:HGNC:29612
See related
Ensembl:ENSG00000162511 MIM:601476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLAST6
Summary
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
Expression
Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues See more
Orthologs

Genomic context

See LAPTM5 in Genome Data Viewer
Location:
1p35.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (30732469..30757840, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31205315..31230683, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378618 Neighboring gene MATN1 antisense RNA 1 Neighboring gene uncharacterized LOC105378620 Neighboring gene matrilin 1 Neighboring gene uncharacterized LOC105378621 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4289 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4291 Neighboring gene microRNA 4420

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lysosomal protein transmembrane 5 (LAPTM5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ61683, FLJ97251, MGC125860, MGC125861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lysosomal-associated transmembrane protein 5
Names
CD40-ligand-activated specific transcripts
human retinoic acid-inducible E3 protein
lysosomal associated multispanning membrane protein 5
lysosomal multispanning membrane protein 5
lysosomal-associated multitransmembrane protein 5
retinoic acid-inducible E3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006762.3NP_006753.1  lysosomal-associated transmembrane protein 5

    See identical proteins and their annotated locations for NP_006753.1

    Status: REVIEWED

    Source sequence(s)
    AL137857, BC106897, D42042
    Consensus CDS
    CCDS337.1
    UniProtKB/Swiss-Prot
    Q13571
    UniProtKB/TrEMBL
    Q5TBB8
    Related
    ENSP00000294507.3, ENST00000294507.4
    Conserved Domains (1) summary
    pfam03821
    Location:28261
    Mtp; Golgi 4-transmembrane spanning transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    30732469..30757840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542098.2XP_011540400.1  lysosomal-associated transmembrane protein 5 isoform X1

    Conserved Domains (1) summary
    cl04276
    Location:30204
    Mtp; Golgi 4-transmembrane spanning transporter
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