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Laptm5 lysosomal-associated protein transmembrane 5 [ Mus musculus (house mouse) ]

Gene ID: 16792, updated on 11-Apr-2024

Summary

Official Symbol
Laptm5provided by MGI
Official Full Name
lysosomal-associated protein transmembrane 5provided by MGI
Primary source
MGI:MGI:108046
See related
Ensembl:ENSMUSG00000028581 AllianceGenome:MGI:108046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E3; Stra13
Summary
Enables enzyme binding activity and protein sequestering activity. Involved in several processes, including lysosomal transport; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in lysosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human LAPTM5 (lysosomal protein transmembrane 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 738.8), spleen adult (RPKM 516.6) and 10 other tissues See more
Orthologs
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Genomic context

See Laptm5 in Genome Data Viewer
Location:
4 D2.2; 4 64.0 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130640627..130663459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130912890..130936148)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11540 Neighboring gene predicted gene, 22660 Neighboring gene predicted gene, 35294 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:130470071-130470326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:130471621-130471838 Neighboring gene predicted gene, 38599 Neighboring gene STARR-seq mESC enhancer starr_11541 Neighboring gene matrilin 1, cartilage matrix protein Neighboring gene uncharacterized LOC108168713 Neighboring gene RIKEN cDNA A930031H19 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi to lysosome transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in induction of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pre-B cell receptor expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lysosomal membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to lysosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysosomal-associated transmembrane protein 5
Names
lysosomal-associated multitransmembrane protein 5
retinoic acid-inducible E3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010686.4NP_034816.1  lysosomal-associated transmembrane protein 5

    See identical proteins and their annotated locations for NP_034816.1

    Status: VALIDATED

    Source sequence(s)
    AL627104
    Consensus CDS
    CCDS18712.1
    UniProtKB/Swiss-Prot
    Q60923, Q61168
    UniProtKB/TrEMBL
    Q3TBK6, Q544S4
    Related
    ENSMUSP00000118415.2, ENSMUST00000151698.8
    Conserved Domains (1) summary
    TIGR00799
    Location:4261
    mtp; Golgi 4-transmembrane spanning transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130640627..130663459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)