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ZNF236 zinc finger protein 236 [ Homo sapiens (human) ]

Gene ID: 7776, updated on 5-Aug-2022

Summary

Official Symbol
ZNF236provided by HGNC
Official Full Name
zinc finger protein 236provided by HGNC
Primary source
HGNC:HGNC:13028
See related
Ensembl:ENSG00000130856 MIM:604760; AllianceGenome:HGNC:13028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF236A; ZNF236B
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.8), ovary (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF236 in Genome Data Viewer
Location:
18q23
Exon count:
36
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (76822557..76972901)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (77051329..77203459)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (74534513..74684857)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904327 Neighboring gene ZNF236 divergent transcript Neighboring gene RNA, U6 small nuclear 346, pseudogene Neighboring gene uncharacterized LOC105372214 Neighboring gene ribosomal protein L26 pseudogene 35 Neighboring gene exportin for tRNA pseudogene Neighboring gene uncharacterized LOC105372217 Neighboring gene myelin basic protein Neighboring gene uncharacterized LOC124904328

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 236
Names
regulated by glucose

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306089.2NP_001293018.1  zinc finger protein 236 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC027575, AC093330
    Consensus CDS
    CCDS77201.1
    UniProtKB/Swiss-Prot
    Q9UL36
    UniProtKB/TrEMBL
    J9JID5
    Related
    ENSP00000322361.9, ENST00000320610.14
    Conserved Domains (5) summary
    COG5048
    Location:197707
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:12551275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:11831207
    zf-H2C2_2; Zinc-finger double domain
  2. NM_007345.4NP_031371.3  zinc finger protein 236 isoform 2

    See identical proteins and their annotated locations for NP_031371.3

    Status: REVIEWED

    Source sequence(s)
    AC027575, AC093330
    Consensus CDS
    CCDS42447.1
    UniProtKB/Swiss-Prot
    Q9UL36, Q9UL37
    Related
    ENSP00000253159.8, ENST00000253159.12
    Conserved Domains (5) summary
    COG5048
    Location:195705
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:12531273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:197219
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:11811205
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    76822557..76972901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526168.3XP_011524470.1  zinc finger protein 236 isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:197550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:12551275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:11831207
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526169.4XP_011524471.1  zinc finger protein 236 isoform X5

    Conserved Domains (5) summary
    COG5048
    Location:197550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:12551275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:11831207
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011526165.4XP_011524467.1  zinc finger protein 236 isoform X1

    See identical proteins and their annotated locations for XP_011524467.1

    UniProtKB/Swiss-Prot
    Q9UL36, Q9UL37
    Conserved Domains (5) summary
    COG5048
    Location:195705
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:12531273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:197219
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:11811205
    zf-H2C2_2; Zinc-finger double domain
  4. XM_047437793.1XP_047293749.1  zinc finger protein 236 isoform X2

  5. XM_011526166.3XP_011524468.1  zinc finger protein 236 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:56566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:11141134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:5880
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:10421066
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    77051329..77203459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)