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ZNF227 zinc finger protein 227 [ Homo sapiens (human) ]

Gene ID: 7770, updated on 1-Jun-2020

Summary

Official Symbol
ZNF227provided by HGNC
Official Full Name
zinc finger protein 227provided by HGNC
Primary source
HGNC:HGNC:13020
See related
Ensembl:ENSG00000131115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 4.1), testis (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF227 in Genome Data Viewer
Location:
19q13.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44207522..44237268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44716684..44741421)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 234 Neighboring gene zinc finger protein 226 Neighboring gene zinc finger protein 233 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene zinc finger protein 235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289166.1NP_001276095.1  zinc finger protein 227 isoform a

    See identical proteins and their annotated locations for NP_001276095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK092253, AL833012, DA494064
    Consensus CDS
    CCDS12636.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000482749.1, ENST00000621083.4
    Conserved Domains (4) summary
    smart00349
    Location:2383
    KRAB; krueppel associated box
    COG5048
    Location:406779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342363
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001289167.1NP_001276096.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276096.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK316048, AL833012, DA494064
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001289168.1NP_001276097.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK299266, AL833012, DA494064
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000467577.1, ENST00000589005.5
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001289169.1NP_001276098.1  zinc finger protein 227 isoform b

    See identical proteins and their annotated locations for NP_001276098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK092253, AL833012, DA494064, DA929840
    Consensus CDS
    CCDS74388.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000375823.2, ENST00000391961.6
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001289170.1NP_001276099.1  zinc finger protein 227 isoform c

    See identical proteins and their annotated locations for NP_001276099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AK092253, AK300576, AL833012, DA494064
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    B7Z6M2, Q658S5
    Conserved Domains (3) summary
    COG5048
    Location:243627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456480
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001289171.1NP_001276100.1  zinc finger protein 227 isoform c

    See identical proteins and their annotated locations for NP_001276100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AL833012, DA494064, DC341721
    UniProtKB/TrEMBL
    B7Z6M2, Q658S5
    Conserved Domains (3) summary
    COG5048
    Location:243627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456480
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001289172.1NP_001276101.1  zinc finger protein 227 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL833012, DA494064, DA514267
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (3) summary
    COG5048
    Location:225609
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:425445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:438462
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001289173.1NP_001276102.1  zinc finger protein 227 isoform e

    See identical proteins and their annotated locations for NP_001276102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in its 5' UTR, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AL833012, BU153285, DA494064
    UniProtKB/TrEMBL
    Q658S5
    Conserved Domains (5) summary
    smart00349
    Location:2365
    KRAB; krueppel associated box
    COG5048
    Location:294678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2362
    KRAB; KRAB box
    pfam13465
    Location:507531
    zf-H2C2_2; Zinc-finger double domain
  9. NM_182490.3NP_872296.1  zinc finger protein 227 isoform a

    See identical proteins and their annotated locations for NP_872296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL833012, BC047570, DA494064
    Consensus CDS
    CCDS12636.1
    UniProtKB/Swiss-Prot
    Q86WZ6
    UniProtKB/TrEMBL
    Q658S5
    Related
    ENSP00000321049.6, ENST00000313040.12
    Conserved Domains (4) summary
    smart00349
    Location:2383
    KRAB; krueppel associated box
    COG5048
    Location:406779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342363
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44207522..44237268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027274.2XP_016882763.1  zinc finger protein 227 isoform X5

  2. XM_017027271.2XP_016882760.1  zinc finger protein 227 isoform X4

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011527289.2XP_011525591.1  zinc finger protein 227 isoform X1

    See identical proteins and their annotated locations for XP_011525591.1

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:2383
    KRAB; krueppel associated box
    COG5048
    Location:406779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342363
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027270.1XP_016882759.1  zinc finger protein 227 isoform X4

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017027275.1XP_016882764.1  zinc finger protein 227 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:252636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:465489
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011527290.1XP_011525592.1  zinc finger protein 227 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:2376
    KRAB; krueppel associated box
    COG5048
    Location:300699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2362
    KRAB; KRAB box
    pfam13465
    Location:528552
    zf-H2C2_2; Zinc-finger double domain
  7. XM_006723371.1XP_006723434.1  zinc finger protein 227 isoform X3

    See identical proteins and their annotated locations for XP_006723434.1

    Conserved Domains (5) summary
    smart00349
    Location:2365
    KRAB; krueppel associated box
    COG5048
    Location:294678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2362
    KRAB; KRAB box
    pfam13465
    Location:507531
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017027272.1XP_016882761.1  zinc finger protein 227 isoform X5

  9. XM_017027277.1XP_016882766.1  zinc finger protein 227 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:252636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:465489
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017027273.2XP_016882762.1  zinc finger protein 227 isoform X5

  11. XM_017027276.2XP_016882765.1  zinc finger protein 227 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:252636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:465489
    zf-H2C2_2; Zinc-finger double domain
  12. XM_017027279.1XP_016882768.1  zinc finger protein 227 isoform X7

    UniProtKB/TrEMBL
    B7Z6M2
    Conserved Domains (3) summary
    COG5048
    Location:243627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:456480
    zf-H2C2_2; Zinc-finger double domain
  13. XM_017027266.1XP_016882755.1  zinc finger protein 227 isoform X1

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:2383
    KRAB; krueppel associated box
    COG5048
    Location:406779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342363
    zf-H2C2_2; Zinc-finger double domain
  14. XM_017027268.1XP_016882757.1  zinc finger protein 227 isoform X4

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  15. XM_017027269.2XP_016882758.1  zinc finger protein 227 isoform X4

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:271655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:484508
    zf-H2C2_2; Zinc-finger double domain
  16. XM_017027267.1XP_016882756.1  zinc finger protein 227 isoform X3

    Conserved Domains (5) summary
    smart00349
    Location:2365
    KRAB; krueppel associated box
    COG5048
    Location:294678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2362
    KRAB; KRAB box
    pfam13465
    Location:507531
    zf-H2C2_2; Zinc-finger double domain
  17. XM_005259232.3XP_005259289.1  zinc finger protein 227 isoform X1

    See identical proteins and their annotated locations for XP_005259289.1

    UniProtKB/Swiss-Prot
    Q86WZ6
    Conserved Domains (4) summary
    smart00349
    Location:2383
    KRAB; krueppel associated box
    COG5048
    Location:406779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342363
    zf-H2C2_2; Zinc-finger double domain
  18. XM_017027278.1XP_016882767.1  zinc finger protein 227 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:252636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:465489
    zf-H2C2_2; Zinc-finger double domain
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