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ZNF224 zinc finger protein 224 [ Homo sapiens (human) ]

Gene ID: 7767, updated on 5-Jan-2022

Summary

Official Symbol
ZNF224provided by HGNC
Official Full Name
zinc finger protein 224provided by HGNC
Primary source
HGNC:HGNC:13017
See related
Ensembl:ENSG00000267680 MIM:194555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMZF2; KOX22; ZNF27; BMZF-2; ZNF233; ZNF255
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in spleen (RPKM 8.7), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF224 in Genome Data Viewer
Location:
19q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44094350..44109831)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44598514..44613979)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene zinc finger protein 225 Neighboring gene zinc finger protein 234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 224
Names
bone marrow zinc finger 2
zinc finger protein 233
zinc finger protein 255
zinc finger protein 27
zinc finger protein KOX22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051221.1 RefSeqGene

    Range
    5033..20558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321645.3NP_001308574.1  zinc finger protein 224

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, CN304667, DA245440, DB228337
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    Q9NZL3
    Related
    ENSP00000508532.1, ENST00000693561.1
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain
  2. NM_013398.5NP_037530.2  zinc finger protein 224

    See identical proteins and their annotated locations for NP_037530.2

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, BC051902, DA245440
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    Q9NZL3
    Related
    ENSP00000337368.5, ENST00000336976.10
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44094350..44109831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027261.2XP_016882750.1  zinc finger protein 224 isoform X1

    UniProtKB/Swiss-Prot
    Q9NZL3
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain
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