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ZNF224 zinc finger protein 224 [ Homo sapiens (human) ]

Gene ID: 7767, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF224provided by HGNC
Official Full Name
zinc finger protein 224provided by HGNC
Primary source
HGNC:HGNC:13017
See related
Ensembl:ENSG00000267680 MIM:194555; AllianceGenome:HGNC:13017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMZF2; KOX22; ZNF27; BMZF-2; ZNF233; ZNF255
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in spleen (RPKM 8.7), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF224 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44094361..44109826)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46917263..46932721)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44598514..44613979)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene zinc finger protein 234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners. Cesaro E, et al. Molecules, 2021 Oct 18. PMID 34684876, Free PMC Article
  2. ZNF224 is a mediator of TGF-β pro-oncogenic function in melanoma. Cesaro E, et al. Hum Mol Genet, 2021 Nov 1. PMID 34181020
  3. A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression. Medugno L, et al. FEBS Lett, 2003 Jan 16. PMID 12527367
  4. Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family. Medugno L, et al. Gene, 2007 Nov 15. PMID 17900823
  5. ZNF224: Structure and role of a multifunctional KRAB-ZFP protein. Lupo A, et al. Int J Biochem Cell Biol, 2011 Apr. PMID 21187159

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF224 is a mediator of TGF-beta pro-oncogenic function in melanoma.
    Title: ZNF224 is a mediator of TGF-β pro-oncogenic function in melanoma.
  2. ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
    Title: ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
  3. identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity.
    Title: ZNF224 is a transcriptional repressor of AXL in chronic myeloid leukemia cells.
  4. The analyses using human breast ductal carcinoma tissues exhibited that the expression of ZNF224 and miR-663a was increased in cancer compared to non-cancer region.
    Title: ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a.
  5. we showed that ZNF224 positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
    Title: Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia.
  6. Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer
    Title: The Complex Role of the ZNF224 Transcription Factor in Cancer.
  7. Data show that Wilms' tumor 1 protein (WT1)binds to the zinc finger protein 224 (ZNF224) promoter and represses ZNF224 expression.
    Title: WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.
  8. ZNF224 acts in fine tuning of WT1-dependent control of gene expression, acting as a co-activator of WT1 in the regulation of proapoptotic genes and suppressing WT1 mediated transactivation of antiapoptotitc genes.
    Title: Role of WT1-ZNF224 interaction in the expression of apoptosis-regulating genes.
  9. REVIEW: ZNF224 is a multifunctional protein and alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity
    Title: ZNF224: Structure and role of a multifunctional KRAB-ZFP protein.
  10. ZNF224 acts as a transcriptional co-regulator of WT1.
    Title: Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 224
Names
bone marrow zinc finger 2
zinc finger protein 233
zinc finger protein 255
zinc finger protein 27
zinc finger protein KOX22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051221.1 RefSeqGene

    Range
    5033..20498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321645.3 → NP_001308574.1  zinc finger protein 224

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, CN304667, DA245440, DB228337
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    A6NFW9, P17033, Q86V10, Q8IZC8, Q9NZL3, Q9UID9, Q9Y2P6
    Related
    ENSP00000508532.1, ENST00000693561.1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542 → 562
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_013398.5 → NP_037530.2  zinc finger protein 224

    See identical proteins and their annotated locations for NP_037530.2

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, BC051902, DA245440
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    A6NFW9, P17033, Q86V10, Q8IZC8, Q9NZL3, Q9UID9, Q9Y2P6
    Related
    ENSP00000337368.5, ENST00000336976.10
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542 → 562
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44094361..44109826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46917263..46932721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZL3.3 GenPept UniProtKB/Swiss-Prot:Q9NZL3

Gene LinkOut

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