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ZNF224 zinc finger protein 224 [ Homo sapiens (human) ]

Gene ID: 7767, updated on 8-Dec-2018

Summary

Official Symbol
ZNF224provided by HGNC
Official Full Name
zinc finger protein 224provided by HGNC
Primary source
HGNC:HGNC:13017
See related
Ensembl:ENSG00000267680 MIM:194555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMZF2; KOX22; ZNF27; BMZF-2; ZNF233; ZNF255
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in spleen (RPKM 8.7), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF224 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (44094329..44109831)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44598482..44613997)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene uncharacterized LOC100379224 Neighboring gene zinc finger protein 225 Neighboring gene zinc finger protein 234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 224
Names
bone marrow zinc finger 2
zinc finger protein 233
zinc finger protein 255
zinc finger protein 27
zinc finger protein KOX22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051221.1 RefSeqGene

    Range
    5001..20502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321645.1NP_001308574.1  zinc finger protein 224

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, CN304667, DA245440, DB228337
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    Q9NZL3
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain
  2. NM_013398.3NP_037530.2  zinc finger protein 224

    See identical proteins and their annotated locations for NP_037530.2

    Status: REVIEWED

    Source sequence(s)
    AA554187, AC021092, AC114266, BC051902, DA245440
    Consensus CDS
    CCDS33046.1
    UniProtKB/Swiss-Prot
    Q9NZL3
    Related
    ENSP00000337368.5, ENST00000336976.10
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    44094329..44109831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027261.2XP_016882750.1  zinc finger protein 224 isoform X1

    UniProtKB/Swiss-Prot
    Q9NZL3
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:202641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:542562
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:275297
    zf-H2C2_2; Zinc-finger double domain
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