U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF214 zinc finger protein 214 [ Homo sapiens (human) ]

Gene ID: 7761, updated on 5-Aug-2022

Summary

Official Symbol
ZNF214provided by HGNC
Official Full Name
zinc finger protein 214provided by HGNC
Primary source
HGNC:HGNC:13006
See related
Ensembl:ENSG00000149050 MIM:605015; AllianceGenome:HGNC:13006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAZ1; BAZ-1
Summary
This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 1.5), thyroid (RPKM 1.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF214 in Genome Data Viewer
Location:
11p15.4
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6997085..7020346, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (7055490..7078724, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7018316..7041577, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 215 Neighboring gene uncharacterized LOC102724711 Neighboring gene Sharpr-MPRA regulatory region 9308 Neighboring gene NLR family pyrin domain containing 14 Neighboring gene Sharpr-MPRA regulatory region 5166 Neighboring gene Sharpr-MPRA regulatory region 4980

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 214
Names
BWSCR2-associated zinc finger protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354830.2NP_001341759.1  zinc finger protein 214 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC100875, BC144405, CA313222
    Conserved Domains (3) summary
    COG5048
    Location:246587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:483503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
  2. NM_001354831.2NP_001341760.1  zinc finger protein 214 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC100875, CA313222
    Consensus CDS
    CCDS31418.1
    UniProtKB/Swiss-Prot
    B2R8Q1
    Related
    ENSP00000445373.1, ENST00000536068.5
    Conserved Domains (3) summary
    COG5048
    Location:235576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:342
    KRAB; KRAB box
  3. NM_001354832.2NP_001341761.1  zinc finger protein 214 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC100875, AK313462, CA313222
    Consensus CDS
    CCDS31418.1
    UniProtKB/Swiss-Prot
    B2R8Q1
    Conserved Domains (3) summary
    COG5048
    Location:235576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:342
    KRAB; KRAB box
  4. NM_001354833.2NP_001341762.1  zinc finger protein 214 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC100875, CA313222, DA299430
    Conserved Domains (2) summary
    COG5048
    Location:221562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_013249.4NP_037381.2  zinc finger protein 214 isoform 2

    See identical proteins and their annotated locations for NP_037381.2

    Status: REVIEWED

    Source sequence(s)
    AA678604, AC100875, AF056617, CA313222, DB262997
    Consensus CDS
    CCDS31418.1
    UniProtKB/Swiss-Prot
    B2R8Q1, Q9UL59
    Related
    ENSP00000278314.4, ENST00000278314.5
    Conserved Domains (3) summary
    COG5048
    Location:235576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:342
    KRAB; KRAB box

RNA

  1. NR_148988.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC100875, BX096368
    Related
    ENST00000525017.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6997085..7020346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718309.5XP_006718372.1  zinc finger protein 214 isoform X2

    See identical proteins and their annotated locations for XP_006718372.1

    Conserved Domains (2) summary
    COG5048
    Location:221562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_047427565.1XP_047283521.1  zinc finger protein 214 isoform X1

    UniProtKB/Swiss-Prot
    B2R8Q1
  3. XM_017018269.3XP_016873758.1  zinc finger protein 214 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:221562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011520357.4XP_011518659.1  zinc finger protein 214 isoform X2

    See identical proteins and their annotated locations for XP_011518659.1

    Conserved Domains (2) summary
    COG5048
    Location:221562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    7055490..7078724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)