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ZSCAN26 zinc finger and SCAN domain containing 26 [ Homo sapiens (human) ]

Gene ID: 7741, updated on 7-Jun-2020

Summary

Official Symbol
ZSCAN26provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 26provided by HGNC
Primary source
HGNC:HGNC:12978
See related
Ensembl:ENSG00000197062 MIM:616474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREZBP; ZNF187; SRE-ZBP
Expression
Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See ZSCAN26 in Genome Data Viewer
Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (28267010..28278224)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28234788..28246001)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 4 Neighboring gene NFKB activating protein like Neighboring gene piggyBac transposable element derived 1 Neighboring gene zinc finger and SCAN domain containing 31 Neighboring gene zinc finger with KRAB and SCAN domains 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2815

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 26
Names
zinc finger protein 187

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001023560.3NP_001018854.2  zinc finger and SCAN domain-containing protein 26 isoform a

    See identical proteins and their annotated locations for NP_001018854.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK095948, AL526328, BC013951, DA566660, GD143716
    UniProtKB/Swiss-Prot
    Q16670
    UniProtKB/TrEMBL
    A0A024RCN4, B3KTR1
    Related
    ENSP00000481707.1, ENST00000421553.6
    Conserved Domains (6) summary
    smart00431
    Location:52158
    SCAN; leucine rich region
    COG5048
    Location:290469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283305
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47135
    SCAN; SCAN domain
    pfam13465
    Location:297322
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001111039.2NP_001104509.1  zinc finger and SCAN domain-containing protein 26 isoform b

    See identical proteins and their annotated locations for NP_001104509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK095948, AK301081, BC013951, DA566660, DA884554, GD143716
    Consensus CDS
    CCDS78119.1
    UniProtKB/Swiss-Prot
    Q16670
    UniProtKB/TrEMBL
    B3KTR1, B4DVH3
    Related
    ENSP00000485228.1, ENST00000623276.3
    Conserved Domains (6) summary
    smart00431
    Location:52157
    SCAN; leucine rich region
    COG5048
    Location:289468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284304
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47135
    SCAN; SCAN domain
    pfam13465
    Location:296321
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001287421.1NP_001274350.1  zinc finger and SCAN domain-containing protein 26 isoform c

    See identical proteins and their annotated locations for NP_001274350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
    Source sequence(s)
    AK301081, AL832741, DA341149, GD143716
    Consensus CDS
    CCDS75414.1
    UniProtKB/Swiss-Prot
    Q16670
    UniProtKB/TrEMBL
    A0A087X2F1, B4DVH3
    Related
    ENSP00000479314.1, ENST00000614088.1
    Conserved Domains (3) summary
    COG5048
    Location:174334
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:162187
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001287422.1NP_001274351.1  zinc finger and SCAN domain-containing protein 26 isoform d

    See identical proteins and their annotated locations for NP_001274351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks two exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant a. It encodes isoform d, which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK095948, AL832741, DA528922, DA566660, GD143716
    Consensus CDS
    CCDS75415.1
    UniProtKB/Swiss-Prot
    Q16670
    UniProtKB/TrEMBL
    B3KTR1, B4DMT1
    Related
    ENSP00000478769.1, ENST00000611552.2
    Conserved Domains (3) summary
    COG5048
    Location:100260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:88113
    zf-H2C2_2; Zinc-finger double domain
  5. NM_152736.5NP_689949.3  zinc finger and SCAN domain-containing protein 26 isoform c

    See identical proteins and their annotated locations for NP_689949.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
    Source sequence(s)
    AK095948, BC013951, DA566660, DB262147, GD143716
    Consensus CDS
    CCDS75414.1
    UniProtKB/Swiss-Prot
    Q16670
    UniProtKB/TrEMBL
    A0A087X2F1, B3KTR1
    Related
    ENSP00000484931.1, ENST00000316606.10
    Conserved Domains (3) summary
    COG5048
    Location:174334
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:162187
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    28267010..28278224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011264.1XP_016866753.1  zinc finger and SCAN domain-containing protein 26 isoform X2

    UniProtKB/Swiss-Prot
    Q16670
    Conserved Domains (6) summary
    smart00431
    Location:52157
    SCAN; leucine rich region
    COG5048
    Location:289468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284304
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47135
    SCAN; SCAN domain
    pfam13465
    Location:296321
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011514862.2XP_011513164.1  zinc finger and SCAN domain-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_011513164.1

    UniProtKB/TrEMBL
    A0A024RCN4
    Related
    ENSP00000484018.1, ENST00000619937.4
    Conserved Domains (6) summary
    smart00431
    Location:52158
    SCAN; leucine rich region
    COG5048
    Location:290469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283305
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47135
    SCAN; SCAN domain
    pfam13465
    Location:297322
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011514866.1XP_011513168.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    See identical proteins and their annotated locations for XP_011513168.1

    Conserved Domains (2) summary
    COG5048
    Location:163323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017011265.1XP_016866754.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:163323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024446539.1XP_024302307.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:163323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024446538.1XP_024302306.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:261440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:23129
    SCAN; SCAN oligomerization domain
  7. XM_011514867.2XP_011513169.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    See identical proteins and their annotated locations for XP_011513169.1

    Conserved Domains (2) summary
    COG5048
    Location:163323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011514869.1XP_011513171.1  zinc finger and SCAN domain-containing protein 26 isoform X4

    See identical proteins and their annotated locations for XP_011513171.1

    Conserved Domains (2) summary
    COG5048
    Location:163323
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011514864.1XP_011513166.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    See identical proteins and their annotated locations for XP_011513166.1

    Conserved Domains (3) summary
    COG5048
    Location:261440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:23129
    SCAN; SCAN oligomerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007151.1: Suppressed sequence

    Description
    NM_007151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate when translated from the upstream AUG.
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