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ZNF180 zinc finger protein 180 [ Homo sapiens (human) ]

Gene ID: 7733, updated on 21-Dec-2019

Summary

Official Symbol
ZNF180provided by HGNC
Official Full Name
zinc finger protein 180provided by HGNC
Primary source
HGNC:HGNC:12970
See related
Ensembl:ENSG00000167384 MIM:606740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHZ168
Summary
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in thyroid (RPKM 1.7), prostate (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF180 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44474443..44500522, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44978645..45004574, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 229 Neighboring gene zinc finger protein 285B (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 2061 Neighboring gene CEA cell adhesion molecule 20 Neighboring gene CEA cell adhesion molecule 22, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • AC069278.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278508.3NP_001265437.2  zinc finger protein 180 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.
    Source sequence(s)
    AC245748, AF192913, AK122688, DA947036
    Consensus CDS
    CCDS62708.1
    UniProtKB/Swiss-Prot
    Q9UJW8
    UniProtKB/TrEMBL
    G5E9B8
    Related
    ENSP00000375818.3, ENST00000391956.8
    Conserved Domains (5) summary
    smart00349
    Location:47108
    KRAB; krueppel associated box
    COG5048
    Location:307667
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4786
    KRAB; KRAB box
    pfam13465
    Location:370395
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001278509.3NP_001265438.2  zinc finger protein 180 isoform 3

    See identical proteins and their annotated locations for NP_001265438.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (3) with a shorter N-terminus, compared to isoform 1. Both variants 3 and 8 encode the same isoform.
    Source sequence(s)
    AC245748, AF192913, AK024047, DA947036
    Consensus CDS
    CCDS62707.1
    UniProtKB/Swiss-Prot
    Q9UJW8
    UniProtKB/TrEMBL
    A0A0A0MP75
    Related
    ENSP00000468021.1, ENST00000592529.5
    Conserved Domains (5) summary
    smart00349
    Location:45106
    KRAB; krueppel associated box
    COG5048
    Location:305665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4584
    KRAB; KRAB box
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001288759.3NP_001275688.2  zinc finger protein 180 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC245748, AF192913, DA947036, DC358291
    UniProtKB/Swiss-Prot
    Q9UJW8
    Conserved Domains (5) summary
    smart00349
    Location:71132
    KRAB; krueppel associated box
    COG5048
    Location:331691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:71110
    KRAB; KRAB box
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001288760.3NP_001275689.1  zinc finger protein 180 isoform 5

    See identical proteins and their annotated locations for NP_001275689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, contains alternate exons, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (5) with a shorter N-terminus, compared to isoform 1. Variants 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AC245748, AF192913, BC051903, DA442282
    UniProtKB/Swiss-Prot
    Q9UJW8
    Conserved Domains (3) summary
    COG5048
    Location:3349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001288761.3NP_001275690.1  zinc finger protein 180 isoform 5

    See identical proteins and their annotated locations for NP_001275690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (5) with a shorter N-terminus, compared to isoform 1. Variants 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AC245748, AF192913, AK024047, DA947036
    UniProtKB/Swiss-Prot
    Q9UJW8
    Conserved Domains (3) summary
    COG5048
    Location:3349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001288762.3NP_001275691.1  zinc finger protein 180 isoform 5

    See identical proteins and their annotated locations for NP_001275691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (5) with a shorter N-terminus, compared to isoform 1. Variants 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AC245748, AF192913, DB223974
    UniProtKB/Swiss-Prot
    Q9UJW8
    Conserved Domains (3) summary
    COG5048
    Location:3349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5277
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001291633.2NP_001278562.1  zinc finger protein 180 isoform 3

    See identical proteins and their annotated locations for NP_001278562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (3) with a shorter N-terminus, compared to isoform 1. Both variants 3 and 8 encode the same isoform.
    Source sequence(s)
    AC245748, AF192913, AU132370, DA947036
    Consensus CDS
    CCDS62707.1
    UniProtKB/Swiss-Prot
    Q9UJW8
    UniProtKB/TrEMBL
    A0A0A0MP75
    Conserved Domains (5) summary
    smart00349
    Location:45106
    KRAB; krueppel associated box
    COG5048
    Location:305665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4584
    KRAB; KRAB box
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain
  8. NM_013256.6NP_037388.3  zinc finger protein 180 isoform 1

    See identical proteins and their annotated locations for NP_037388.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC245748, AF192913, AK122688, DA947036
    Consensus CDS
    CCDS12639.1
    UniProtKB/Swiss-Prot
    Q9UJW8
    Related
    ENSP00000221327.3, ENST00000221327.8
    Conserved Domains (5) summary
    smart00349
    Location:72133
    KRAB; krueppel associated box
    COG5048
    Location:332692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:72111
    KRAB; KRAB box
    pfam13465
    Location:395420
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44474443..44500522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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