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Dennd2b DENN domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 76954, updated on 2-Nov-2024

Summary

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Official Symbol
Dennd2bprovided by MGI
Official Full Name
DENN domain containing 2Bprovided by MGI
Primary source
MGI:MGI:108517
See related
Ensembl:ENSMUSG00000031024 AllianceGenome:MGI:108517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St5; Denn2b; 2010004M01Rik; 2610305K15Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be located in cell cortex; plasma membrane; and recycling endosome. Is expressed in several structures, including brain; future brain; head mesenchyme; heart; and primary palate. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 22.8), ovary adult (RPKM 12.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd2b in Genome Data Viewer
Location:
7 E3; 7 57.27 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109123118..109302828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109523911..109703718, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24888 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3 Neighboring gene STARR-seq mESC enhancer starr_19802 Neighboring gene STARR-seq mESC enhancer starr_19804 Neighboring gene STARR-positive B cell enhancer ABC_E4965 Neighboring gene VISTA enhancer mm1407 Neighboring gene A kinase interacting protein 1 Neighboring gene cDNA sequence BC051019 Neighboring gene predicted gene, 51493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice. Ou K, et al. Mol Metab, 2018 May. PMID 29650351, Free PMC Article
  2. Disruption of ST5 is associated with mental retardation and multiple congenital anomalies. Göhring I, et al. J Med Genet, 2010 Feb. PMID 19843505
  3. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Kleyn PW, et al. Cell, 1996 Apr 19. PMID 8612280
  4. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cichutek A, et al. Cytogenet Cell Genet, 2001. PMID 11528126
  5. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. Amid C, et al. Cytogenet Cell Genet, 2001. PMID 11528127

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST5 overexpression has no mitogenic effect on the adult beta-cell under basal and metabolically challenged states.
    Title: Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 2B
Names
heLa tumor suppression 1
suppression of tumorigenicity 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001326.1 → NP_001001326.1  DENN domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001001326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC124457, AC126441
    Consensus CDS
    CCDS21734.1
    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Related
    ENSMUSP00000078264.2, ENSMUST00000079282.8
    Conserved Domains (3) summary
    smart00801
    Location:1020 → 1086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788 → 969
    DENN; DENN (AEX-3) domain

  2. NM_029811.2 → NP_084087.2  DENN domain-containing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_084087.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC124457, AC126441
    Consensus CDS
    CCDS21735.1
    UniProtKB/Swiss-Prot
    Q924W7
    Related
    ENSMUSP00000130119.2, ENSMUST00000168005.8
    Conserved Domains (3) summary
    smart00801
    Location:603 → 669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277 → 364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371 → 552
    DENN; DENN (AEX-3) domain

RNA

  1. NR_037617.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124457, AK008100, CF737707, CF749727, CN460946

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109123118..109302828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241941.3 → XP_011240243.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240243.1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  2. XM_030243084.2 → XP_030098944.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  3. XM_011241940.4 → XP_011240242.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240242.1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  4. XM_011241945.4 → XP_011240247.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240247.1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  5. XM_036153554.1 → XP_036009447.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  6. XM_011241944.4 → XP_011240246.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240246.1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  7. XM_030243087.2 → XP_030098947.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  8. XM_030243086.2 → XP_030098946.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  9. XM_011241942.4 → XP_011240244.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240244.1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  10. XM_030243085.1 → XP_030098945.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:1045 → 1111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813 → 994
    DENN; DENN (AEX-3) domain

  11. XM_030243089.2 → XP_030098949.1  DENN domain-containing protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Conserved Domains (3) summary
    smart00801
    Location:1020 → 1086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788 → 969
    DENN; DENN (AEX-3) domain

  12. XM_006508320.5 → XP_006508383.1  DENN domain-containing protein 2B isoform X2

    See identical proteins and their annotated locations for XP_006508383.1

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Conserved Domains (3) summary
    smart00801
    Location:1020 → 1086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788 → 969
    DENN; DENN (AEX-3) domain

  13. XM_030243088.2 → XP_030098948.1  DENN domain-containing protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Related
    ENSMUSP00000077067.2, ENSMUST00000077909.9
    Conserved Domains (3) summary
    smart00801
    Location:1020 → 1086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788 → 969
    DENN; DENN (AEX-3) domain

  14. XM_036153555.1 → XP_036009448.1  DENN domain-containing protein 2B isoform X4

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  15. XM_030243090.2 → XP_030098950.1  DENN domain-containing protein 2B isoform X3

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  16. XM_030243091.2 → XP_030098951.1  DENN domain-containing protein 2B isoform X5

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694 → 781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RNA

  1. XR_003946582.2 RNA Sequence

  2. XR_004934206.1 RNA Sequence

  3. XR_004934205.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924W7.1 GenPept UniProtKB/Swiss-Prot:Q924W7

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