U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dennd2b DENN domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 76954, updated on 5-Mar-2024

Summary

Official Symbol
Dennd2bprovided by MGI
Official Full Name
DENN domain containing 2Bprovided by MGI
Primary source
MGI:MGI:108517
See related
Ensembl:ENSMUSG00000031024 AllianceGenome:MGI:108517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St5; Denn2b; 2010004M01Rik; 2610305K15Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Predicted to be located in endosome and plasma membrane. Is expressed in several structures, including brain; future brain; head mesenchyme; heart; and primary palate. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 22.8), ovary adult (RPKM 12.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
7 E3; 7 57.27 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109123118..109302828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109523911..109703718, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24888 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3 Neighboring gene STARR-seq mESC enhancer starr_19802 Neighboring gene STARR-seq mESC enhancer starr_19804 Neighboring gene STARR-positive B cell enhancer ABC_E4965 Neighboring gene VISTA enhancer mm1407 Neighboring gene A kinase interacting protein 1 Neighboring gene cDNA sequence BC051019 Neighboring gene predicted gene, 51493

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DENN domain-containing protein 2B
Names
heLa tumor suppression 1
suppression of tumorigenicity 5 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001326.1NP_001001326.1  DENN domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001001326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC124457, AC126441
    Consensus CDS
    CCDS21734.1
    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Related
    ENSMUSP00000078264.2, ENSMUST00000079282.8
    Conserved Domains (3) summary
    smart00801
    Location:10201086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788969
    DENN; DENN (AEX-3) domain
  2. NM_029811.2NP_084087.2  DENN domain-containing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_084087.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC124457, AC126441
    Consensus CDS
    CCDS21735.1
    UniProtKB/Swiss-Prot
    Q924W7
    Related
    ENSMUSP00000130119.2, ENSMUST00000168005.8
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain

RNA

  1. NR_037617.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124457, AK008100, CF737707, CF749727, CN460946

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109123118..109302828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241941.3XP_011240243.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240243.1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  2. XM_030243084.2XP_030098944.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  3. XM_011241940.4XP_011240242.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240242.1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  4. XM_011241945.4XP_011240247.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240247.1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  5. XM_036153554.1XP_036009447.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  6. XM_011241944.4XP_011240246.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240246.1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  7. XM_030243087.2XP_030098947.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  8. XM_030243086.2XP_030098946.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  9. XM_011241942.4XP_011240244.1  DENN domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011240244.1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  10. XM_030243085.1XP_030098945.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10451111
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:813994
    DENN; DENN (AEX-3) domain
  11. XM_030243089.2XP_030098949.1  DENN domain-containing protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Conserved Domains (3) summary
    smart00801
    Location:10201086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788969
    DENN; DENN (AEX-3) domain
  12. XM_006508320.5XP_006508383.1  DENN domain-containing protein 2B isoform X2

    See identical proteins and their annotated locations for XP_006508383.1

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Conserved Domains (3) summary
    smart00801
    Location:10201086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788969
    DENN; DENN (AEX-3) domain
  13. XM_030243088.2XP_030098948.1  DENN domain-containing protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
    Related
    ENSMUSP00000077067.2, ENSMUST00000077909.9
    Conserved Domains (3) summary
    smart00801
    Location:10201086
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:788969
    DENN; DENN (AEX-3) domain
  14. XM_036153555.1XP_036009448.1  DENN domain-containing protein 2B isoform X4

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  15. XM_030243090.2XP_030098950.1  DENN domain-containing protein 2B isoform X3

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  16. XM_030243091.2XP_030098951.1  DENN domain-containing protein 2B isoform X5

    UniProtKB/TrEMBL
    Q3TYX0
    Conserved Domains (1) summary
    smart00800
    Location:694781
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RNA

  1. XR_003946582.2 RNA Sequence

  2. XR_004934206.1 RNA Sequence

  3. XR_004934205.1 RNA Sequence