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Conserved domains on  [gi|755523290|ref|XP_011240247|]
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DENN domain-containing protein 2B isoform X1 [Mus musculus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
814-997 3.33e-71

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 235.17  E-value: 3.33e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    814 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 893
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    894 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLV 971
Cdd:smart00799   78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157
                           170       180
                    ....*....|....*....|....*.
gi 755523290    972 GLLSSSLPKLKELPVEEALMVNLGSD 997
Cdd:smart00799  158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
694-781 1.34e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.86  E-value: 1.34e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800    5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78
                            90
                    ....*....|.
gi 755523290    771 SRRFGYCRRLL 781
Cdd:smart00800   79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
1045-1111 8.23e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 78.49  E-value: 8.23e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   1045 NGLVSEVFIRFFVETVGHYSLFLT---HSEKGERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 1111
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
814-997 3.33e-71

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 235.17  E-value: 3.33e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    814 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 893
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    894 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLV 971
Cdd:smart00799   78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157
                           170       180
                    ....*....|....*....|....*.
gi 755523290    972 GLLSSSLPKLKELPVEEALMVNLGSD 997
Cdd:smart00799  158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
813-994 5.83e-69

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 426618 [Multi-domain]  Cd Length: 184  Bit Score: 228.72  E-value: 5.83e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   813 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA-ALVYPFMRS-LMESPFPAPGKTIKVKtflpGAGNEVLELRRPMDSR 890
Cdd:pfam02141    1 RIPKAYCIISRLPFFTLFKKILDELYTRRTISPlLPLERFIANlLYEVPFPPPGRTQKLK----LGVTELILLQRPEDSE 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   891 L--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTP 968
Cdd:pfam02141   77 LpgEGVDLHALFRCLSPENILQLFEAALLERRIIFLSEDPARLSLVAEALVALLYPFVWQHIYIPVLPASLLDVLSAPTP 156
                          170       180
                   ....*....|....*....|....*.
gi 755523290   969 FLVGLLSSSLPkLKELPVEEALMVNL 994
Cdd:pfam02141  157 FIIGVHSRYFD-LLEDPLDDVVLVDL 181
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
694-781 1.34e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.86  E-value: 1.34e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800    5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78
                            90
                    ....*....|.
gi 755523290    771 SRRFGYCRRLL 781
Cdd:smart00800   79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
1045-1111 8.23e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 78.49  E-value: 8.23e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   1045 NGLVSEVFIRFFVETVGHYSLFLT---HSEKGERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 1111
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
713-779 2.03e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 427307  Cd Length: 59  Bit Score: 68.79  E-value: 2.03e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755523290   713 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 779
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPL------PDAIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRVYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
1077-1125 4.35e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 427306  Cd Length: 49  Bit Score: 58.76  E-value: 4.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 755523290  1077 FQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDRELRKCRAK-GLFEQR 1125
Cdd:pfam03455    1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSSDPSiDLFDEE 49
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
814-997 3.33e-71

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 235.17  E-value: 3.33e-71
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    814 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 893
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    894 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLV 971
Cdd:smart00799   78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157
                           170       180
                    ....*....|....*....|....*.
gi 755523290    972 GLLSSSLPKLKELPVEEALMVNLGSD 997
Cdd:smart00799  158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
813-994 5.83e-69

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 426618 [Multi-domain]  Cd Length: 184  Bit Score: 228.72  E-value: 5.83e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   813 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA-ALVYPFMRS-LMESPFPAPGKTIKVKtflpGAGNEVLELRRPMDSR 890
Cdd:pfam02141    1 RIPKAYCIISRLPFFTLFKKILDELYTRRTISPlLPLERFIANlLYEVPFPPPGRTQKLK----LGVTELILLQRPEDSE 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   891 L--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTP 968
Cdd:pfam02141   77 LpgEGVDLHALFRCLSPENILQLFEAALLERRIIFLSEDPARLSLVAEALVALLYPFVWQHIYIPVLPASLLDVLSAPTP 156
                          170       180
                   ....*....|....*....|....*.
gi 755523290   969 FLVGLLSSSLPkLKELPVEEALMVNL 994
Cdd:pfam02141  157 FIIGVHSRYFD-LLEDPLDDVVLVDL 181
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
694-781 1.34e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.86  E-value: 1.34e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290    694 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 770
Cdd:smart00800    5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78
                            90
                    ....*....|.
gi 755523290    771 SRRFGYCRRLL 781
Cdd:smart00800   79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
1045-1111 8.23e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 78.49  E-value: 8.23e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523290   1045 NGLVSEVFIRFFVETVGHYSLFLT---HSEKGERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 1111
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
713-779 2.03e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 427307  Cd Length: 59  Bit Score: 68.79  E-value: 2.03e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755523290   713 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 779
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPL------PDAIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRVYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
1077-1125 4.35e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 427306  Cd Length: 49  Bit Score: 58.76  E-value: 4.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 755523290  1077 FQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDRELRKCRAK-GLFEQR 1125
Cdd:pfam03455    1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSSDPSiDLFDEE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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