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DENND2B DENN domain containing 2B [ Homo sapiens (human) ]

Gene ID: 6764, updated on 13-Mar-2020

Summary

Official Symbol
DENND2Bprovided by HGNC
Official Full Name
DENN domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:11350
See related
Ensembl:ENSG00000166444 MIM:140750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST5; HTS1; p126
Summary
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 30.7), testis (RPKM 16.0) and 24 other tissues See more
Orthologs

Genomic context

See DENND2B in Genome Data Viewer
Location:
11p15.4
Exon count:
40
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (8693352..8910951, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8714899..8932498, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3983 Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a Neighboring gene uncharacterized LOC107984308 Neighboring gene uncharacterized LOC105376539 Neighboring gene uncharacterized LOC102724784 Neighboring gene RNA, 5S ribosomal pseudogene 330 Neighboring gene chromosome 11 open reading frame 16 Neighboring gene A-kinase interacting protein 1 Neighboring gene achaete-scute family bHLH transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33090

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
suppression of tumorigenicity 5 protein
Names
DENN/MADD domain containing 2B
heLa tumor suppression 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029450.1 RefSeqGene

    Range
    5001..222600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001376495.1NP_001363424.1  suppression of tumorigenicity 5 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  2. NM_001376496.1NP_001363425.1  suppression of tumorigenicity 5 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  3. NM_001376497.1NP_001363426.1  suppression of tumorigenicity 5 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  4. NM_001376498.1NP_001363427.1  suppression of tumorigenicity 5 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  5. NM_001376499.1NP_001363428.1  suppression of tumorigenicity 5 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  6. NM_001376500.1NP_001363429.1  suppression of tumorigenicity 5 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  7. NM_001376501.1NP_001363430.1  suppression of tumorigenicity 5 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Related
    ENSP00000436802.1, ENST00000530438.5
  8. NM_001376502.1NP_001363431.1  suppression of tumorigenicity 5 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  9. NM_001376503.1NP_001363432.1  suppression of tumorigenicity 5 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  10. NM_001376504.1NP_001363433.1  suppression of tumorigenicity 5 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  11. NM_001376505.1NP_001363434.1  suppression of tumorigenicity 5 protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Related
    ENSP00000432887.1, ENST00000530991.5
  12. NM_001376506.1NP_001363435.1  suppression of tumorigenicity 5 protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  13. NM_005418.4NP_005409.3  suppression of tumorigenicity 5 protein isoform 1

    See identical proteins and their annotated locations for NP_005409.3

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Consensus CDS
    CCDS7791.1
    UniProtKB/Swiss-Prot
    P78524
    Related
    ENSP00000433528.1, ENST00000534127.5
    Conserved Domains (3) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain
  14. NM_139157.3NP_631896.1  suppression of tumorigenicity 5 protein isoform 2

    See identical proteins and their annotated locations for NP_631896.1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Consensus CDS
    CCDS7792.1
    UniProtKB/Swiss-Prot
    P78524
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  15. NM_213618.2NP_998783.1  suppression of tumorigenicity 5 protein isoform 1

    See identical proteins and their annotated locations for NP_998783.1

    Status: REVIEWED

    Source sequence(s)
    BC036655, BX647431, U15131, U15780
    Consensus CDS
    CCDS7791.1
    UniProtKB/Swiss-Prot
    P78524
    Related
    ENSP00000319678.6, ENST00000313726.11
    Conserved Domains (3) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain

RNA

  1. NR_164814.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  2. NR_164815.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  3. NR_164816.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  4. NR_164817.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  5. NR_164818.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  6. NR_164819.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  7. NR_164820.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  8. NR_164821.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  9. NR_164822.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    8693352..8910951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520329.1XP_011518631.1  suppression of tumorigenicity 5 protein isoform X9

    See identical proteins and their annotated locations for XP_011518631.1

    UniProtKB/Swiss-Prot
    P78524
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  2. XM_011520324.2XP_011518626.2  suppression of tumorigenicity 5 protein isoform X8

  3. XM_005253077.1XP_005253134.1  suppression of tumorigenicity 5 protein isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:10531119
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:8211002
    DENN; DENN (AEX-3) domain
  4. XM_011520309.1XP_011518611.1  suppression of tumorigenicity 5 protein isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10731139
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:8411022
    DENN; DENN (AEX-3) domain
  5. XM_011520320.1XP_011518622.1  suppression of tumorigenicity 5 protein isoform X4

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:841958
    DENN; DENN (AEX-3) domain
  6. XM_011520322.1XP_011518624.1  suppression of tumorigenicity 5 protein isoform X7

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:822883
    DENN; DENN (AEX-3) domain
  7. XM_011520321.2XP_011518623.1  suppression of tumorigenicity 5 protein isoform X5

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:842903
    DENN; DENN (AEX-3) domain

RNA

  1. XR_002957165.1 RNA Sequence

  2. XR_002957167.1 RNA Sequence

  3. XR_002957164.1 RNA Sequence

  4. XR_002957176.1 RNA Sequence

  5. XR_002957182.1 RNA Sequence

  6. XR_002957162.1 RNA Sequence

  7. XR_002957171.1 RNA Sequence

  8. XR_002957188.1 RNA Sequence

  9. XR_002957172.1 RNA Sequence

  10. XR_002957166.1 RNA Sequence

  11. XR_002957168.1 RNA Sequence

  12. XR_002957169.1 RNA Sequence

  13. XR_002957178.1 RNA Sequence

  14. XR_002957170.1 RNA Sequence

  15. XR_002957184.1 RNA Sequence

  16. XR_002957179.1 RNA Sequence

  17. XR_002957177.1 RNA Sequence

  18. XR_002957187.1 RNA Sequence

  19. XR_002957183.1 RNA Sequence

  20. XR_002957175.1 RNA Sequence

  21. XR_002957163.1 RNA Sequence

  22. XR_002957173.1 RNA Sequence

  23. XR_002957185.1 RNA Sequence

  24. XR_002957160.1 RNA Sequence

  25. XR_002957174.1 RNA Sequence

  26. XR_002957186.1 RNA Sequence

  27. XR_002957181.1 RNA Sequence

  28. XR_002957180.1 RNA Sequence

  29. XR_002957161.1 RNA Sequence

  30. XR_001747941.1 RNA Sequence

  31. XR_930887.2 RNA Sequence

  32. XR_002957159.1 RNA Sequence

  33. XR_001747943.1 RNA Sequence

  34. XR_001747942.1 RNA Sequence

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