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DENND2B DENN domain containing 2B [ Homo sapiens (human) ]

Gene ID: 6764, updated on 11-Jun-2021

Summary

Official Symbol
DENND2Bprovided by HGNC
Official Full Name
DENN domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:11350
See related
Ensembl:ENSG00000166444 MIM:140750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST5; HTS1; p126
Summary
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 30.7), testis (RPKM 16.0) and 24 other tissues See more
Orthologs
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Genomic context

See DENND2B in Genome Data Viewer
Location:
11p15.4
Exon count:
40
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (8693352..8910951, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8714899..8932498, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3983 Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a Neighboring gene uncharacterized LOC107984308 Neighboring gene uncharacterized LOC105376539 Neighboring gene uncharacterized LOC102724784 Neighboring gene RNA, 5S ribosomal pseudogene 330 Neighboring gene chromosome 11 open reading frame 16 Neighboring gene A-kinase interacting protein 1 Neighboring gene achaete-scute family bHLH transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33090

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DENN domain-containing protein 2B
Names
DENN/MADD domain containing 2B
heLa tumor suppression 1
suppression of tumorigenicity 5 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029450.1 RefSeqGene

    Range
    5001..222600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001376495.1NP_001363424.1  DENN domain-containing protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (4) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain
  2. NM_001376496.1NP_001363425.1  DENN domain-containing protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (4) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain
  3. NM_001376497.1NP_001363426.1  DENN domain-containing protein 2B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (4) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain
  4. NM_001376498.1NP_001363427.1  DENN domain-containing protein 2B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:854920
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:622803
    DENN; DENN (AEX-3) domain
  5. NM_001376499.1NP_001363428.1  DENN domain-containing protein 2B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:843909
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:517604
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:611792
    DENN; DENN (AEX-3) domain
  6. NM_001376500.1NP_001363429.1  DENN domain-containing protein 2B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:796862
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:470557
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:564745
    DENN; DENN (AEX-3) domain
  7. NM_001376501.1NP_001363430.1  DENN domain-containing protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Related
    ENSP00000436802.1, ENST00000530438.5
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  8. NM_001376502.1NP_001363431.1  DENN domain-containing protein 2B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  9. NM_001376503.1NP_001363432.1  DENN domain-containing protein 2B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:543609
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:311492
    DENN; DENN (AEX-3) domain
    cl04085
    Location:277314
    uDENN; uDENN domain
  10. NM_001376504.1NP_001363433.1  DENN domain-containing protein 2B isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:531597
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:205292
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:299480
    DENN; DENN (AEX-3) domain
  11. NM_001376505.1NP_001363434.1  DENN domain-containing protein 2B isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Related
    ENSP00000432887.1, ENST00000530991.5
    Conserved Domains (3) summary
    smart00801
    Location:495561
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:169256
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:263444
    DENN; DENN (AEX-3) domain
  12. NM_001376506.1NP_001363435.1  DENN domain-containing protein 2B isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Conserved Domains (3) summary
    smart00801
    Location:495561
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:169256
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:263444
    DENN; DENN (AEX-3) domain
  13. NM_005418.4NP_005409.3  DENN domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_005409.3

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Consensus CDS
    CCDS7791.1
    UniProtKB/Swiss-Prot
    P78524
    Related
    ENSP00000433528.1, ENST00000534127.5
    Conserved Domains (4) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain
  14. NM_139157.3NP_631896.1  DENN domain-containing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_631896.1

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
    Consensus CDS
    CCDS7792.1
    UniProtKB/Swiss-Prot
    P78524
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  15. NM_213618.2NP_998783.1  DENN domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_998783.1

    Status: REVIEWED

    Source sequence(s)
    BC036655, BX647431, U15131, U15780
    Consensus CDS
    CCDS7791.1
    UniProtKB/Swiss-Prot
    P78524
    Related
    ENSP00000319678.6, ENST00000313726.11
    Conserved Domains (4) summary
    smart00801
    Location:10231089
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:697784
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:46411
    PHA03247; large tegument protein UL36; Provisional
    pfam02141
    Location:791972
    DENN; DENN (AEX-3) domain

RNA

  1. NR_164814.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  2. NR_164815.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  3. NR_164816.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  4. NR_164817.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  5. NR_164818.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  6. NR_164819.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  7. NR_164820.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  8. NR_164821.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053
  9. NR_164822.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC026894, AC091053

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    8693352..8910951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520329.1XP_011518631.1  DENN domain-containing protein 2B isoform X9

    See identical proteins and their annotated locations for XP_011518631.1

    UniProtKB/Swiss-Prot
    P78524
    Conserved Domains (3) summary
    smart00801
    Location:603669
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:277364
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:371552
    DENN; DENN (AEX-3) domain
  2. XM_011520324.2XP_011518626.2  DENN domain-containing protein 2B isoform X8

  3. XM_005253077.1XP_005253134.1  DENN domain-containing protein 2B isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:10531119
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:8211002
    DENN; DENN (AEX-3) domain
  4. XM_011520309.1XP_011518611.1  DENN domain-containing protein 2B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:10731139
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:8411022
    DENN; DENN (AEX-3) domain
  5. XM_011520320.1XP_011518622.1  DENN domain-containing protein 2B isoform X4

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:841958
    DENN; DENN (AEX-3) domain
  6. XM_011520322.1XP_011518624.1  DENN domain-containing protein 2B isoform X7

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:822883
    DENN; DENN (AEX-3) domain
  7. XM_011520321.2XP_011518623.1  DENN domain-containing protein 2B isoform X5

    Conserved Domains (2) summary
    smart00800
    Location:727814
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:842903
    DENN; DENN (AEX-3) domain

RNA

  1. XR_002957165.1 RNA Sequence

  2. XR_002957167.1 RNA Sequence

  3. XR_002957164.1 RNA Sequence

  4. XR_002957176.1 RNA Sequence

  5. XR_002957182.1 RNA Sequence

  6. XR_002957162.1 RNA Sequence

  7. XR_002957171.1 RNA Sequence

  8. XR_002957188.1 RNA Sequence

  9. XR_002957172.1 RNA Sequence

  10. XR_002957166.1 RNA Sequence

  11. XR_002957168.1 RNA Sequence

  12. XR_002957169.1 RNA Sequence

  13. XR_002957178.1 RNA Sequence

  14. XR_002957170.1 RNA Sequence

  15. XR_002957184.1 RNA Sequence

  16. XR_002957179.1 RNA Sequence

  17. XR_002957177.1 RNA Sequence

  18. XR_002957187.1 RNA Sequence

  19. XR_002957183.1 RNA Sequence

  20. XR_002957175.1 RNA Sequence

  21. XR_002957163.1 RNA Sequence

  22. XR_002957173.1 RNA Sequence

  23. XR_002957185.1 RNA Sequence

  24. XR_002957160.1 RNA Sequence

  25. XR_002957174.1 RNA Sequence

  26. XR_002957186.1 RNA Sequence

  27. XR_002957181.1 RNA Sequence

  28. XR_002957180.1 RNA Sequence

  29. XR_002957161.1 RNA Sequence

  30. XR_001747941.1 RNA Sequence

  31. XR_930887.2 RNA Sequence

  32. XR_002957159.1 RNA Sequence

  33. XR_001747943.1 RNA Sequence

  34. XR_001747942.1 RNA Sequence

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