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ZNF136 zinc finger protein 136 [ Homo sapiens (human) ]

Gene ID: 7695, updated on 12-Oct-2019

Summary

Official Symbol
ZNF136provided by HGNC
Official Full Name
zinc finger protein 136provided by HGNC
Primary source
HGNC:HGNC:12920
See related
Ensembl:ENSG00000196646 MIM:604078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-20
Summary
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.2), ovary (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF136 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12163047..12189881)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12273872..12300064)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372275 Neighboring gene ZNF625-ZNF20 readthrough (NMD candidate) Neighboring gene ribosomal protein L17 pseudogene 47 Neighboring gene zinc finger protein 625 Neighboring gene uncharacterized LOC100289333 Neighboring gene zinc finger protein 791-like Neighboring gene zinc finger protein 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052983.1 RefSeqGene

    Range
    5050..31825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348013.1NP_001334942.1  zinc finger protein 136 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK299601, AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
    UniProtKB/Swiss-Prot
    P52737
    UniProtKB/TrEMBL
    B4DS70
    Conserved Domains (2) summary
    COG5048
    Location:91460
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:188208
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001348014.1NP_001334943.1  zinc finger protein 136 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL537987, BC006421, BP420506, BQ574220, CN429121, DA783495, DB369850
    UniProtKB/Swiss-Prot
    P52737
    Related
    ENSP00000498578.1, ENST00000652580.1
    Conserved Domains (2) summary
    COG5048
    Location:125494
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222242
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_003437.5NP_003428.1  zinc finger protein 136 isoform 1

    See identical proteins and their annotated locations for NP_003428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer/longest* isoform (1).
    Source sequence(s)
    AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
    Consensus CDS
    CCDS32916.1
    UniProtKB/Swiss-Prot
    P52737
    Related
    ENSP00000344162.4, ENST00000343979.6
    Conserved Domains (3) summary
    COG5048
    Location:157526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:344
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12163047..12189881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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