Format

Send to:

Choose Destination

ZNF69 zinc finger protein 69 [ Homo sapiens (human) ]

Gene ID: 7620, updated on 5-Jan-2022

Summary

Official Symbol
ZNF69provided by HGNC
Official Full Name
zinc finger protein 69provided by HGNC
Primary source
HGNC:HGNC:13138
See related
Ensembl:ENSG00000198429 MIM:194543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cos5; hZNF3
Summary
Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in kidney (RPKM 1.9), colon (RPKM 1.9) and 25 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF69 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11887773..11980222)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11998597..12025371)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10901 Neighboring gene vomeronasal 2 receptor 14 pseudogene Neighboring gene zinc finger protein 440-like Neighboring gene vomeronasal 2 receptor 15 pseudogene Neighboring gene zinc finger protein 700 Neighboring gene Sharpr-MPRA regulatory region 6121 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene zinc finger protein 763 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC59928

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 69
Names
ZNF3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321163.2NP_001308092.1  zinc finger protein 69 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008770, AW132096, BG393583, BG429615
    Conserved Domains (2) summary
    smart00349
    Location:2464
    KRAB; krueppel associated box
    pfam01352
    Location:2463
    KRAB; KRAB box
  2. NM_001364730.1NP_001351659.1  zinc finger protein 69 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008770, BG393583, DA647393
    Related
    ENSP00000402985.2, ENST00000429654.7
    Conserved Domains (3) summary
    COG5048
    Location:219537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2364
    KRAB; KRAB box
  3. NM_001364731.1NP_001351660.1  zinc finger protein 69 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008770, DA633065
    Conserved Domains (3) summary
    COG5048
    Location:205523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:348368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2250
    KRAB; KRAB box
  4. NM_021915.4NP_068734.1  zinc finger protein 69 isoform 2

    See identical proteins and their annotated locations for NP_068734.1

    Status: VALIDATED

    Source sequence(s)
    AC008770, AW132096, BC051309, BG393583
    Consensus CDS
    CCDS32914.1
    UniProtKB/Swiss-Prot
    Q9UC07
    Related
    ENSP00000345333.5, ENST00000340180.5
    Conserved Domains (1) summary
    pfam01352
    Location:2250
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11887773..11980222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027231.1XP_016882720.1  zinc finger protein 69 isoform X3

    Conserved Domains (2) summary
    smart00349
    Location:2767
    KRAB; krueppel associated box
    pfam01352
    Location:2766
    KRAB; KRAB box
  2. XM_006722874.3XP_006722937.1  zinc finger protein 69 isoform X2

    See identical proteins and their annotated locations for XP_006722937.1

    Related
    ENSP00000388784.1, ENST00000445911.5
    Conserved Domains (2) summary
    smart00349
    Location:2767
    KRAB; krueppel associated box
    pfam01352
    Location:2766
    KRAB; KRAB box
  3. XM_006722873.4XP_006722936.1  zinc finger protein 69 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:2767
    KRAB; krueppel associated box
    COG5048
    Location:222540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:405430
    zf-H2C2_2; Zinc-finger double domain
Support Center